Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment: Advancing an Integrated Approach

David J. Libon; Melissa Lamar; Rodney A. Swenson; Kenneth M. Heilman
Pub date
Mar 2020
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Alzheimer's disease (AD) and vascular dementia (VaD) are commonly viewed as the first and second most common types of dementia, respectively. The traditional paradigm has been to view and treat each illness as a separate entity with a separate pathophysiology. However, clinical and pathological studies suggest that the boundary separating AD and VaD, as well as their mild cognitive impairment (MCI) analogs, is not well defined. Thus, there is increased interest in viewing these diseases along a spectrum because of the significant overlap in the characterization and diagnosis of AD, VaD, and MCI. The focus of this edited volume is to examine how AD and VaD, as well as their MCI analogs, are best viewed as a heterogeneous, intersecting, if not a continuous disease state rather than separate, distinct entities. This book examines this approach by providing empirically based evidence, reviews of the literature, and chapters by key leaders in the field and will be of interest to clinical neuropsychologists and anyone studying or treating dementia in its many forms.


Part 1: Epidemiology and Neuropsychology
Chapter 1: Vascular risk factors and their relationship to brain aging: Findings from the Framingham Heart Study
Chapter 2: Neuropsychological Profiles in Alzheimer's/ Vascular Spectrum Dementia
Chapter 3: Neuropsychological Diagnostic Criteria for Mild Cognitive Impairment due to Alzheimer's Disease
Chapter 4: Vascular Cognitive Impairment
Chapter 5: Decline in Everyday Functioning in MCI and Dementia: A Neuropsychological Perspective
Chapter 6: Heterogeneity in Dementia and MCI: Using Statistical Modeling Techniques
Chapter 7: Apraxic and Action-Intentional Disorders Associated With Vascular And Degenerative Dementing Diseases
Part 2: Neuroimaging
Chapter 8: Cerebral small vessel disease and the risk of dementia and cognition decline
Chapter 9: Structural MRI in Alzheimer's disease: Are we measuring the right stuff
Chapter 10: Advances in Multi-Modal Imaging Across the Spectrum of Normal to Pathological aging: Incorporating Vascular Comorbidities Common to Alzheimer's disease and Vascular Dementia
Part 3: Blood-Brain-Barrier and Cardiogenic Mechanisms
Chapter 11: The Blood-Brain Barrier in Cognitive Decline and Alzheimer's Disease
Chapter 12: Arterial Stiffening and Cerebrovascular Resistance in Cognitive Decline and Alzheimer's Disease
Chapter 13: Hemodynamics in Alzheimer's Disease and Vascular Cognitive Impairment & Dementia
Part 4: Neuropathological and Neurophysiological Mechanisms
Chapter 14: Neuropathology of AD/ VaD Dementia
Chapter 15: Potential of blood- and CSF-based biomarkers for AD diagnostics
Chapter 16: Unravelling the Role of Mitochondria in Alzheimer's disease: Toward Assembling the Puzzle
Part 5: Treatment and Intervention
Chapter 17: Dementia and Elective Surgeries: Considerations for Neuropsychologists
Chapter 18: Management of Mild Cognitive Impairment

About the author: 

David J. Libon is Professor of Geriatrics, Gerontology, and Psychology at the New Jersey Institute for Successful Aging, School of Osteopathic Medicine, Rowan University. Melissa Lamar is a licensed Clinical Neuropsychologist and an Associate Professor in the Department of Behavioral Sciences and a full-time Cognitive Neuroscientist within the Rush Alzheimer's Disease Center at the Rush University Medical Center. Rodney A. Swenson is a board certified Neuropsychologist and Clinical Professor of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences. Kenneth M. Heilman is a Distinguished Professor Emeritus at the University of Florida.

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