The Migraine Brain: Imaging Structure and Function

ISBN : 9780199754564

David Borsook; Arne May; Peter J. Goadsby; Richard Hargreaves
400 ページ
223 x 282 mm

The Migraine Brain, edited by David Borsook, Arne May, Peter J. Goadsby, and Richard Hargreaves, makes a major contribution to the field, addressing the increasingly sophisticated neuroimaging techniques that have allowed researchers to begin to define functional and anatomical characteristics of migraine and other less-common types of headache. Of particular focus is how imaging is changing the way we understand migraine. This includes changes in function, structure and chemistry of the migraine brain. Included are sections that focus on particular aspects of migraine, for example the migraine aura: those symptoms that cause visual sensitivity (blinding white light), sensory difficulty (loud noises, painful touch, and hot/cold spells), slurred language, and motor dysfunction. Extensively illustrated throughout, The Migraine Brain provides a general overview of the history of migraine, its pathophysiology, as well as in-depth details on the Clinical Perspectives and the different imaging techniques in use (MR, fMRI, DTI, VBM, PET, fMRI, and MEG). It also includes details on modulation of the brain using such techniques as TMS. The book concludes with a discussion of future uses of imaging in the diagnosis and treatment of migraines and other headaches. A collation of the top thinkers in the field and the only book of its kind, The Migraine Brain is necessary reading for neurologists and neuroscientists.


I. Migraine: History
Chapter 1: A History of Migraine, Mervyn Eadie
II. Neurobiology of the Migraine Brain
Chapter 2: Migraine - Some Theories and Controversies, Farooq Maniyar and Peter J. Goadsby
Chapter 3: Neural System Changes in Migraine, Peter D. Drummond
Chapter 4: Sensitization of Trigeminovascular Pathway: Implications to Migraine Pathophysiology, Rami Burstein and David Borsook
Chapter 5: Brain Measures of the Interictal Migraine Brain State (IMBS), Nasim Maleki, Lino Becerra, and David Borsook
Chapter 6: From Episodic to Chronic Migraine, Richard B. Lipton and Marcelo E. Bigal
Chapter 7: Concomitant Symptoms in Migraine, Arne May & Anne Stankewitz
III. Clinical Perspective
Chapter 8: Clinical Neuroimaging of Migraine, Randolph W. Evans
Chapter 9: Prophylaxis: What Measures?, Stephen Silberstein
Chapter 10: Iron Accumulation in Migraine, Inge H. Palm-Meinders, Michel D. Ferrari, Mark C. Kruit
Chapter 11 : Migraine and Brain Lesions, Inge H. Palm-Meinders, Michel D. Ferrari, Mark C. Kruit
Chapter 12: Clinical Utility of Objective Measures, Franz Riederer, Andreas R. Gantenbein & Peter S. Sandor
Chapter 13: Migraine Genes - Clinical and Preclinical Perspectives, Claudia M. Weller, Boukje de Vries, Gisela M Terwindt, Michel D. Ferrari, Joost Haan, and Arn M.J.M. van den Maagdenberg
IV. Imaging Migraine
Chapter 14: Imaging migraine: A history, Jes Olesen and Peer Tfelt-Hansen
Chapter 15: Focus on the Midbrain, Hans-Christoph Diener, Arne May
Chapter 16: Diffusion Weighted Imaging in Migraine, Christos Sidiropoulos and Panayiotis D. Mitsias
Maria A. Rocca and Massimo Filippi
Chapter 18: Morphometric changes and VBM, Arne May
Chapter 20: Changing receptors in Migraine state, Genevieve Demarquay and Francois Mauguiere
Chapter 21: 15O PET studies in migraine, Marie Denuelle, Pierre Payoux, Nelly Fabre and Gilles Geraud
Chapter 22 : Imaging activation in the migraine state, Till Sprenger, Christian Seifert, Peter J. Goadsby
Chapter 23: Metabolites and migraine, Caterina Tonon, Giulia Pierangeli, Sabina Cevoli, Pietro Cortelli, Raffaele Lodi
Chapter 24: Visual aura, Nouchine Hadjikhani, Maurice B. Vincent
Chapter 25: Functional Imaging of the Migraine Brain: New Insights into Brain Dysfunction, Eric A. Moulton
Chapter 26: TMS and MEG studies in migraine, Sheena K Aurora, Sidra Saeed, and Susan M Bowyer
Chapter 27: Magnetic Resonance Angiography and Migraine, M. Sohail Asghar and Messoud Ashina
Chapter 28: Transcranial Magnetic Stimulation (TMS) / Repetitive Transcranial Magnetic Stimulation (rTMS), Magdalena Sarah Volz and Felipe Fregni
Chapter 29: Measures of cortical excitability, Gianluca Coppola and Jean Schoenen
Chapter 30: Drug Effects on Cortical Excitability, Susan M. Bowyer and Panayiotis D. Mitsias
V. Conclusions
Chapter 31: Defining the Migraine Phenotype, Todd J. Schwedt and David W. Dodick
Chapter 32: The Future of Imaging in Migraine Diagnosis and Treatment, David Borsook and Lino Becerra
Chapter 33: Can Imaging Effectively Transform Migraine Treatment?, David Borsook, Arne May, Peter Goadsby, Richard Hargreaves


David Borsook, MD, PhD Director, Pain & Analgesia Imaging Neuroscience (P.A.I.N.) Group McLean Hospital, Masschusetts General Hospital, and Children's Hospital Belmont, MA Arne May, MD, PhD Institut fur Systemische Neurowissenschaften Zentrum fur Experimentelle Medizin Universitatsklinikum Hamburg-Eppendorf Hamburg, Germany Peter Goadsby, MD, PhD Director, UCSF Headache Center Department of Neurology University of California, San Francisco San Francisco, CA Richard Hargreaves, PhD Vice President Worldwide Discovery Head Neuroscience Merck Research Laboratories West Point PA and Kenilworth, NJ