OXFORD UNIVERSITY PRESS

Cardiac Mechano-electric Coupling and Arrhythmias (2nd edition)

ISBN : 9780199570164

参考価格(税込): 
¥32,868
著者: 
Peter Kohl; Frederick Sachs; Michael R. Franz
ページ
512 ページ
フォーマット
Hardcover
サイズ
230 x 282 mm
刊行日
2011年08月
メール送信
印刷

Cardiac Mechano-Electric Coupling and Arrhythmias offers a thoroughly reviewed compendium written by leading experts in the field on the mechanism and consequences of cardiac mechano-electrical coupling. Its coverage ranges from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction. Information is grouped into logical sections, from molecular mechanisms, to cell, tissue and whole organ responses, right through to patient-based observations and insight emerging from clinical trials. The information provided carefully highlights both consensus insight and current shortcomings in our understanding of cardiac mechano-electric coupling. The book has been thoroughly revised and expanded since publication of the first edition in 2005, extensively updated to reflect recent developments in the field, and now offers a more balanced view of mechano-electrical interactions in the heart and develops a more clinical focus. Written with the practising cardiologist and junior doctor in mind, it offers interesting new insight for the established physician with an interest in cardiac arrhythmogenesis and heart rhythm management.

目次: 

BASIC SCIENCE, SECTION I: SUB-CELLULAR MECHANISMS OF CARDIAC MECHANO-ELECTRIC COUPLING
1. Evolutionary origins of stretch-activated ion channels
2. SACs in the heart
3. The mechano-gated K2P channel TREK-1 in the cardiovascular system
4. Cell VolumeDSSensitive Ion Channels and Transporters in Cardiac Myocytes
5. Non-sarcolemmal stretch-activated channels
6. Pacemaker, potassium, calcium, sodium: stretch modulation of the voltage-gated channels
7. Role of caveolae in stretch-sensing: implications for mechanoelectric coupling
8. The membrane/cytoskeleton interface and stretch-activated channels
9. Cardiomyocyte stretch sensing
10. The response of cardiac muscle to stretch: Calcium and force
11. Stretch effects on second messengers
12. Functional implications of Myocyte Architecture
BASIC SCIENCE, SECTION II: CELLULAR MANIFESTATIONS OF CARDIAC MECHANO-ELECTRIC COUPLING
13. Mechanical modulation of pacemaker electrophysiology
14. Mechano-electric coupling in working cardiomyocytes: diastolic and systolic effects
15. Mechano-sensitivity of pulmonary vein cells: implications for atrial arrhythmogenesis
16. Heterogeneity of sarcomere length and function as a cause of arrhythmogenic calcium waves
17. Cellular mechanisms of arrhythmogenic cardiac alternans
18. Remodeling of gap junctions in ventricular myocardium: Effects of cell-to-cell adhesion, mediators of hypertrophy and mechanical forces
19. The origin of fibroblasts, ECM and potential contributions to cardiac mechano-electric coupling
20. Advantages and pitfalls of cell cultures as model systems to study cardiac mechanoelectric coupling
BASIC SCIENCE, SECTION III: MULTI-CELLULAR MANIFESTATIONS OF MECHANO-ELECTRIC COUPLING
21. Activation sequence of cardiac muscle in simplified experimental models: Relevance for cardiac mechano electric coupling
23. Acute stretch effects on atrial electro-physiology
24. Stretch effects on potassium accumulation and alternans in pathological myocardium
25. The effects of wall stretch on ventricular conduction and refractoriness in the whole heart
26. Mechanical triggers of long-term ventricular electrical remodeling
27. Mechanisms of mechanical pre- and postconditioning
TRANSLATIONAL SCIENCE, SECTION IV: INTEGRATED MODEL SYSTEMS TO STUDY SPECIFIC CASES OF CARDIAC MEC AND ARRHYTHMIAS
28. Mechano-electric coupling in chronic atrial fibrillation
29. Mechanically induced pulmonary vein ectopy - insight from animal models
30. Regional variation in mechano-electric coupling: The right ventricle
31. Mechanical induction of arrhythmia in the ex-situ heart: insight into Commotio Cordis
32. Arrhythmias in murine models of the mechanically impaired heart
33. Studying cardiac mechano-sensitivity in man
34. Mathematical models of cardiac structure and function: mechanistic insights from models of heart failure
35. Mathematical models of human atrial mechano-electrical coupling and arrhythmias
36. Mathematical models of ventricular mechano-electric coupling and arrhythmia
CLINICAL RELEVANCE, SECTION V: PATHOPHYSIOLOGY OF CARDIAC MECHANO-ELECTRIC COUPLING: GENERAL ASPECTS
37. Load dependence of ventricular repolarisation
38. Is the U wave in the electrocardiogram a mechanoelectrical phenomenon?
39. Mechanical modulation of cardiac function: Role of the pericardium
40. Mechanically-induced electrical remodelling in human atrium
41. Drug effects and atrial fibrillation: potential and limitations
42. Stretch as a mechanism linking short- and long-term electrical remodeling in the ventricles
43. Volume and pressure overload and ventricular arrhythmogenesis
44. Stretch effects on fibrillation dynamics
CLINICAL RELEVANCE, SECTION VI: PATHOPHYSIOLOGY OF CARDIAC MECHANO-ELECTRIC COUPLING: SPECIFIC CASES
45. Commotio cordis: Sudden death from blows to the chest wall
46. Repolarization changes in the synchronously and dys-synchronously contracting failing heart
47. Ventricular arrhythmias in heart failure: Link to hemodynamic load
48. Mechanical heterogeneity and aftercontractions as trigger of torsades des pointes
49. Stretch-induced arrhythmias in ischaemia
CLINICAL RELEVANCE, SECTION VII: MECHANO-ELECTRIC COUPLING AS A MECHANISM INVOLVED IN THERAPEUTIC INTERVENTIONS
50. Antiarrhythmic effects of acute mechanical stimulation
51. Termination of arrhythmias by haemodynamic unloading
52. Mechanical modulation of defibrillation and resuscitation efficacy
53. Anti- and pro-arrhythmic effects of cardiac assist device implantation
54. Anti- and pro-arrhythmic effects of cardiac resynchronization therapy
CLINICAL RELEVANCE, SECTION VIII: EVIDENCE FOR MECHANO-ELECTRIC COUPLING FROM CLINICAL TRIALS
55. Evidence for mechano-electric coupling from clinical trials on AF
56. Evidence for mechano-electric coupling from clinical trials in heart failure
57. Mechano-electrical coupling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy
58. Evidence for mechano-electric coupling from clinical trials on cardiac resynchronization therapy
59. Mechano-electric coupling in patients treated with ventricular assist devices: insights from individual cases and clinical trials
OUTLOOK, SECTION IX: NOVEL DIRECTIONS IN CARDIAC MECHANO-ELECTIC COUPLING
60. Measuring strain of structural proteins in vivo in real time
61. Roles of SAC beyond M-E Transaction
62. Distributions of myocyte stress, strain and work in normal and infarcted ventricles
63. Evolving concepts in measuring ventricular strain in the canine and human hearts: non-invasive imaging
64. Evolving concepts in measuring ventricular strain in the human heart: impedance measurements
65. Mechanosensitive channel blockers: A new class of antiarrhythmic drugs?

著者について: 

Professor Peter Kohl, Chair in Cardiac Biophysics and r stems Biology at the National Heart and Lung Institute, Imperial College London, UK; Reader in Cardiac Physiology at the University of Oxford; Senior Fellow of the British Heart Foundation. His research crosses traditional boundaries between fields (engineering, biophysics, biology, computing) and levels (ion channel to whole organ) of investigation, focussing at cardiac structure-function relations with relevance for cardiac mechano-electric interactions. ; Professor Frederick Sachs, Distinguished Professor and Chair of Biophysics at State University of New York (SUNY), Buffalo NY, USA. As the original discoverer of mechano-sensitive ion channels in heart cells, he spearheaded their characterization, aided by his identification of a first selective inhibitor of these channels. More recently he developed the first fluorescent probes that sense mechanical stress in proteins, and he focuses now on their application to dystrophy and other diseases. ; Professor Michael R Franz, Director of Arrhythmia Research at the Veteran Medical Center and Adjunct Professor of Medicine and Pharmacology at Georgetown University Medical Center, Washington DC, USA. His development of a non-injuring technique to record monophasic action potentials has helped to study electrophysiology and arrhythmia mechanisms in patients world-wide. His own research has targeted cardiac electro-mechanics and stretch-induced arrhythmogenesis.

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