Pancreas, Islet and Stem Cell Transplantation for Diabetes (2nd edition)

ISBN : 9780199565863

Nadey S. Hakim; Robert Stratta; Derek Gray; Peter Friend; Alan Coleman
544 ページ
176 x 249 mm

Pancreas transplantation has rapidly moved from an experimental procedure associated with high rates of morbidity and mortality to a mainstream technique with excellent patient and graft survival. Over 30,000 pancreas transplants have already been performed. The value of pancreas transplantation however must be balanced against the risk of the operative procedure and the innovative long-term immunosuppressive therapy. The indications for this procedure and the selection of the patients are critical to ensure low mortality and any improvements in quality of life. This second edition reflects recent advances in the field, especially the increasing number of islet transplantations and the growing interest in stem cell research applicable to this condition. It provides an authoritative account on the current status of the whole organ pancreas transplantation and islet and pancreatic stem cell transplantation.


1. The history of pancreas transplantation
2. The nature of the problem: why do we need pancreatic transplantation?
3. Experimental models in whole organ pancreatic transplantation
4. Indications, patient evaluation and selection
5. Donor management and selection in pancreas transplantation
6. Procurement and benchwork preparation of the pancreatic graft
7. Pancreas preservation
8. Surgical techniques of pancreas transplantation
9. Immunosuppression for pancreas transplantation
10. Pancreatic rejection: histology, diagnosis and treatment
11. Surgical complications of pancreas transplantation
12. Medical and urological complications of pancreas and kidney/ pancreas transplantation
13. Post-transplant glucose intolerance
14. Long term metabolic and other consequences of pancreas and islet transplantation
15. Quality issues in pancreas transplantation
16. Pancreas transplantation using living donors
17. Pancreas transplant outcomes for United States (US) cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR)
18. Insulin Gene Therapy
19. A historical view for the development of cellular and islet transplantation
20. Fetal and neonatal pancreatic tissue transplantation
21. Experimental approaches to the prevention of islet rejection
22. Suitable donor selection, techniques of islet isolation and purification for human islet allograft transplantation
23. Outcomes and clinical effectiveness of islet transplantation
24. Islet auto-transplantation
25. Approaches to immunological tolerance and potential application in pancreatic islet transplantation
26. History of pancreatic stem cell transplantation and alternative islet sources
27. Stem cell therapy for the treatment of diabetes
28. Future challenges in Beta cell replacement therapies
29. Beta cell regenearation in the post-natal pancreas
30. Gene and stem cell therapy for diabetes


Nadey S. Hakim, Consultant in General Surgery, Hammersmith Hospital, London, UK; Robert J. Stratta, Professor of Surgery, Director of Transplantation, Wake Forest University School of Medicine, USA; Derek Gray, Professor of Experimental Surgery, Nuffield Department of Surgery, University of Oxford, UK; Peter Friend, Consultant in General Surgery, Nuffield Department of Surgery, University of Oxford, UK; Alan Colman, Executive Director, Singapore Stem Cell Consortium, Institute of Medical Biology, Singapore