The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease (2nd edition)

ISBN : 9780199559176

Klaus Olgaard; Isidro B. Salusky; Justin Silver
616 ページ
157 x 234 mm
Oxford Clinical Nephrology Series

Despite significant improvement in the management of patients with chronic kidney disease, the morbidity and mortality remain high. However more is now understood about the hormonal influence on bone and vascular structures, and there have been major advances in the field of bone and mineral metabolism. This has lead to the development of new treatment strategies and agents. This new second edition reflects the most current thinking and understanding in this fascinating field, as presented by world basic and clinical experts.


1. Definition and classification of renal osteodystrophy and chronic kidney disease-mineral bone disorder (CKD-MBD)
2. New aspects of normal bone biology
3. Osteocytes and mineral metabolism
4. Calcium-sensing receptors (CaSRs) in kidney, bone and vessels
5. Regulation of parathyroid hormone biosynthesis and gene expression
6. Abnormal parathyroid gland function in CKD
7. PTHrP physiology and pathophysiology, and the PTH/PTHrP receptor
8. Vitamin D metabolism and action in CKD
9. Growth factors and cytokines in renal bone disease
10. Bone histomorphometry in renal osteodystrophy
11. The spectrum of renal osteodystrophy and vascular calcifications in uremia
12. Imaging of the skeleton and the joints in CKD
13. Non-invasive assessment of vascular calcification and arterial stiffness
14. Osteopenia in uremia
15. Acidosis and renal bone disease
16. Dialysis-associated amyloidosis
17. Pathogenesis of vascular calcification: experimental studies
18. Clinical consequences of arterial calcifications and soft-tissue calcifications in Chronic Kidney Disease
19. Clinical management of vascular and soft tissue calcifications in Chronic Kidney Disease patients
20. The role of the skeleton in the pathogenesis of vascular calcification in the Chronic Kidney Disease-Mineral Bone Disorder
21. Klotho: bone, kidney, vascular calcifications, and the ageing process
22. Physiology and pathology of calcium and magnesium transport
23. Phosphatonins in health and disease
24. FGF-23 in renal failure
25. New vitamin D analogs for chronic kidney disease patients
26. Calcimimetics and calcilytics in the treatment of chronic kidney disease-mineral and bone disorder
27. Medical therapy in chronic kidney disease
28. Chronic kidney disease-mineral and bone disorder (CKD-MBD) in children
29. Bone disease in renal transplant recipients
30. Imaging and intervention of parathyroid hyperplasia
31. Surgical management of secondary hyperparathyroidism
32. Morbidity and mortality related to disturbances in mineral metabolism in CKD


Klaus Olgaard is Professor of Nephrology and Internal Medicine at the University of Copenhagen and at Department of Nephrology, Rigshospitalet, Copenhagen, Denmark. His scientific interests are basic and clinical research in nephrology-endocrinology and uremia, especially related to physiology and pathophysiology of calcium, phosphorus, parathyroid hormone (PTH), PTH related peptide, vitamin D, renal osteodystrophy, vascular calcifications and post-transplant bone disease. Professor Olgaard was the President for the ERA-EDTA Congress held in Copenhagen in 2002. He is Past President of several national nephrology and transplantation societies including the Danish Society of Nephrology. He is subject editor for Nephrology Dialysis Transplantation, and has been a member of several editorial boards. Professor Olgaard has authored more than 210 publications in peer-reviewed international journals and was editor of the K/DIGO guidelines, 2006 on Bone and Mineral Metabolism in CKD. ; Justin Silver is Professor of Medicine at the Hebrew University Hadassah Medical School and Chief of the Nephrology and Hypertension Services at Hadassah Hospital in Jerusalem. He is Director of the Minerva Center for Calcium and Bone Metabolism at Hadassah Hospital. Together with his colleague Tally Naveh-Many Ph.D. He studies the molecular biology of the parathyroid and in particular the pathophysiology of the secondary hyperparathyroidism of chronic renal failure. In ongoing work in their laboratory they study how calcium and phosphate regulate PTH gene expression. Professor Silver has published more than 160 papers and reviews on this and related fields, including fifteen book chapters.; Isidro B. Salusky is a Distinguished Professor of Pediatrics at the David Geffen School of Medicine at UCLA. He is the Director of UCLA General Clinical Research Center, Director of the Pediatric Dialysis Program and Associate Dean for Clinical Research. Dr Salusky and his colleagues have made substantial contributions to the understanding and treatment of the bone and mineral abnormalities associated with chronic kidney disease in children. They have characterized the spectrum of renal osteodystrophy in paediatric patients as well as the effects of therapy with different vitamin D sterols. One of the seminal contributions was identification of vascular calcifications in children and young adults treated with dialysis. More recently, his work is focused on the specific actions of fibroblast growth factor 23(FGF-23) on bone and in the pathogenesis of chronic kidney disease-mineral bone disorder (CKD-MBD).