Neuroscience for Clinicians: Basic Processes, Circuits, Disease Mechanisms, and Therapeutic Implications

ISBN : 9780190948894

Eduardo E. Benarroch
832 ページ
216 x 279 mm

Neuroscience for Clinicians is a comprehensive and clinically relevant survey of emerging concepts on the organization and function of the nervous system and neurologic disease mechanisms. By emphasizing how genetic, molecular, and cellular processes and their interactions control the function of the nervous system, the work will help clinicians understand emerging concepts about the mechanisms of neurologic disorders including neurodegeneration, channelopathies, and synaptic dysfunction that provide potential therapeutic targets . This single-authored textbook utilizes ample figures and tables throughout in order to facilitate retention of the core concepts presented. Divided into 5 sections, the first section includes chapters focused on basic cellular processes. Section 2 includes chapters focused on cell communication while Section 3 focuses on the neuronal microenvironment. The fourth section focuses on the organization and interactions of circuits in the cortex, thalamus, and brainstem, underlying behavioral states such as sleep, sensory processing, and motor control. The fifth section addresses mechanisms of pain and neural control of survival. And the final section covers concepts on mechanisms of emotion, social behavior, memory, language, and executive functions with emphasis on dementia and behavioral disorders.


Section I: Molecular and Cellular Mechanisms
Ch1. Overview: Cellular Components of the Nervous System and Disease Mechanisms
Ch2. Organization of the Cell Membranes
Ch3. Intracellular Signaling
Ch4. DNA: Epigenetic Control of Transcription and Repair Mechanisms
Ch5. RNA Metabolism and Control of Translation
Ch6. Proteostasis
Ch7. Vesicular Trafficking
Ch8. Cytoskeleton
Ch9. Axonal Transport
Ch10. Axon and Myelin
Ch11. Mitochondria and Energy Metabolism
Ch12. Mechanisms of Cell Death and Axonal Degeneration
Ch13. Growth Factors, Survival, and Regeneration
Section II: Excitability, Signal Communication, and Plasticity
Ch14. Ion Channels and Channelopathies
Ch15. Principles of Synaptic Transmission and Presynaptic Synaptopahies
Ch16. Neurotransmission, Neuromodulation, and Plasticity
Ch17. Glutamatergic Transmission, Plasticity and Synaptopahies
Ch18. Inhibitory Amino Acid Transmission and Synaptopahies
Ch19. Cholinergic Transmission
Ch20. Monoaminergic Neurotransmission
Section III: Microenvironment and Mechanisms of Injury and repair
Ch21. Astrocyte-Neuron Interactions
Ch22. Neuronal Microenvironment
Ch23. Microglia and Inflammation in the Nervous System
Section III: Neuronal Interactions in Cortical and Subcortical Circuits
Ch24. Neocortical Circuits
Ch25. Hippocampal and Amygdala Circuits
Ch26. Thalamocortical Interactions
Ch27. Sleep
Ch28. Behavioral State Control
Ch29. Sensory Processing
Ch30. Cortical Motor Control
Ch31. Segmental Spinal Motor Control
Ch32. Brainstem Motor Control
Ch33. Cerbellum
Ch34. Basal ganglia
Section V: Homeostatic Systems
Ch35. Nociceptors
Ch36. Central Pain Processing and Modulation
Ch37. Autonomic Nervous System
Ch38. Forebrain Control of Homeostasis and Adaptation
Section VI: Cortical Networks and Cognitive Domains
Ch39. Emotion and Social Cognition
Ch40. Episodic Memory, Navigation, and Inner Thoughts
Ch41. Language, Speech, and Semantic Cognition
Ch42. Cortical Executive Networks and High-level Behavioral and Cognitive Control


Eduardo E. Benarroch Professor of Neurology Department of Neurology, Mayo Clinic, Rochester, MN