Oxford Textbook of Endocrinology and Diabetes 3e (3rd edition)

ISBN : 9780198870197

John Wass; Wiebke Arlt; Robert Semple
1300 ページ
Multiple Copy Pack
219 x 276 mm

Now in its third edition, the Oxford Textbook of Endocrinology and Diabetes is an up-to-date, objective and comprehensive text that covers the full scope of endocrinology and diabetes. It contains wide ranging and pragmatic advice on diagnosis and clear guidelines for recommended management, while also covering the scientific principles that underlie the medical practice in this important field. The book has been re-organised into 15 overarching sections, with new sections on Endocrinology of Pregnancy and Management of the Transgender Patient included. All other sections have been extensively updated and restructured. Each chapter is written by an internationally acknowledged expert, relates basic science to evidence based guidelines and clinical management, and where appropriate offers an outline of the controversies in the subject. The textbook has an international focus and deals with subject matter applicable across the globe. The new edition has over 800 images complementing the extensive text and information provided. The book is a 'one-stop' text for trainees and consultants in Endocrinology and Diabetes, residents, those preparing for sub-specialty exams and other professionals allied to the area who need to gain an understanding of the field. It acts as both a point of reference for the experienced consultant as well as a trusted training resource. Purchase of the print work also includes full access to the online edition of the textbook for the life of the edition.


1. Principles of basic and clinical endocrinology
1.1 Lynn Loriaux: Endocrine Practice Fundamentals
1.2 John W. Funder: Hormones and receptors: fundamental considerations
1.3 Ken Siddle and Gemma Brierley: Molecular aspects of hormonal regulation
1.4 Janine A. Danks and Samantha J. Richardson: Endocrinology and evolution: lessons from comparative endocrinology
1.5 James Gibney, Indi Banerjee, and Ken Ho: Hormones Across the Lifespan
1.6 Brian Keevil, Peter Trainer, and William Drake: Pituitary assessment strategy
1.7 Simon Pearce and Catherine Owen: Endocrine autoimmunity
1.8 Jerome Bertherat, Anne Jouinot, and Fideline Bonnet-Serrano: Common Features of Endocrine Tumours
1.9 Trevor Cole: Genetic Aspects of Endocrine Disease
1.10 George Mastorakos, Markella Nezi, Djuro Macut, and Maria Papagianni: Environmental Influences on Endocrine Disease
1.11 Georg Brabant and H. Oster: Endocrinology, sleep and circadian rhythms
1.12 Richard Ross: Principles of Hormone replacement
1.13 Jonathan Valabhji and Rochan Agha-Jaffar: Prevention in endocrinology
2. Pituitary and hypothalamic diseases
2.1 John Morris: Functional anatomy of the hypothalamus and pituitary
2.2 Stephen G. Ball: The neurohypophysis
2.3 Aetiology, pathogenesis, and management of disease of the pituitary
2.3.1 Mehul T. Dattani and Louise C. Gregory: Development of the pituitary and genetic forms of hypopituitarism
2.3.2 Shlomo Melmed: Molecular pathogenesis of pituitary tumours
2.3.3 Luis Syro, Kalman Kovacs, and Fabio Rotondo: Histopathology of pituitary tumours
2.3.4 Jean-Francois Bonneville, Sonia Nagi, and Iulia Potorac: Imaging of the pituitary
2.3.5 Miles J. Levy, Ragini Bhake, and Narendra Reddy: Hypopituitarism: replacement of adrenal, thyroid, and gonadal axes
2.3.6 Jens Jorgensen: Adult growth hormone deficiency
2.3.7 Edward R. Laws Jr, David L. Penn, and Caroline S. Repetti: Surgery of pituitary tumours
2.3.8 Naomi Fersht and Francesca Solda: Pituitary radiotherapy
2.3.9 Nicholas Tritos and Anne Klibanski: Prolactinomas and hyperprolactinaemia (including macroprolactinaemia)
2.3.10 John Wass, Peter J. Trainer, and Marta Korbonits: Acromegaly
2.3.11 Nienke Biermasz and Wouter R. van Furth: Clinically nonfunctioning pituitary tumours and gonadotropinomas
2.3.12 Mark Gurnell, Olympia Koulouri, and Waiel Bashari: Thyrotropinomas
2.3.13 Ann McCormack: Pituitary carcinoma
2.3.14 Niki Karavitaki, Shu Teng Chai, and Shahzada Ahmed: Pituitary incidentalomas
2.4 Aetiology, pathogenesis, and management of diseases of the hypothalamus
2.4.1 Mehul Dattani, Hoong-Wei Gan, and Manuela Cerbone: Hypothalamic dysfunction (hypothalamic syndromes)
2.4.2 Niki Karavitaki: Craniopharyngiomas
2.4.3 Jurgen Honegger, Ulrike Ernemann, and Rudi Beschorner: Perisellar tumours including cysts, hamartomas, and vascular tumours
2.4.4 Mark E. Molitch and Jelena Kravarusic: Lymphocytic hypophysitis and other inflammatory conditions of the pituitary
2.5 Susan M Webb, Anna Aulinas, Cristina Colom, and Jose Barahona: Pineal physiology and pathophysiology, including pineal tumours
3. The Thyroid
3.1 Evaluation of the thyroid patient
3.1.1 Robert Volpe and Clark Sawin: The history and iconography relating to the thyroid gland
3.1.2 W. Edward Visser: Biosynthesis, transport, metabolism, and actions of thyroid hormones
3.1.3 Inge Bulow Pedersen and Stig Andersen: Clinical assessment of the thyroid patient
3.1.4 Ulla Feldt-Rasmussen: Thyroid function tests and the effects of drugs
3.1.5 Robin P. Peeters and Anita Boelen: Nonthyroidal illness syndrome
3.1.6 Steen Bonnema and Laszlo Hegedus: Thyroid imaging: nuclear medicine techniques
3.1.7 Laszlo Hegedus and Finn N. Bennedbaek: Thyroid imaging: nonisotopic techniques
3.1.8 Mark P. J. Vanderpump: Epidemiology of thyroid disease and swelling
3.2 Aetiology of thyroid disorders
3.2.1 Terry Davies, Francesca Menconi, and Yaron Tomer: The complex genetics of thyroid disease
3.2.2 Josef Kohrle: Environmental factors
3.2.3 Michael B. Zimmermann: Iodine deficiency disorders
3.2.4 Shunichi Yamashita, Furio Pacini, and Rossella Elisei: Radiation-induced thyroid disease
3.2.5 Anthony P. Weetman: Autoimmune thyroid disease
3.2.6 Elizabeth N. Pearce and Alan Farwell: Thyroiditis
3.3 Thyrotoxicosis and related disorders
3.3.1 Claudio Marcocci and Filomena Cetani: Clinical assessment and systemic manifestations of thyrotoxicosis
3.3.2 Annie W. C. Kung and C.L. Cheung: Thyrotoxic periodic paralysis
3.3.3 Leonard Wartofsky, Dorina Ylli, and Joanna Klubo-Gwiezdzinska: Thyrotoxic storm
3.3.4 Simon Pearce: Subclinical hyperthyroidism
3.3.5 Francesco Latrofa and Paolo Vitti: Causes and laboratory investigations of thyrotoxicosis
3.3.6 Luigi Bartalena: Anti-thyroid drug treatment for thyrotoxicosis
3.3.7 Markus Luster and Michael Lassmann: Radio-iodine treatment of hyperthyroidism
3.3.8 Nancy Dugal Perrier, Orlo Clark, and Sarah B. Fisher: Surgery for thyrotoxicosis
3.3.9 Jacques Orgiazzi: Management of Graves hyperthyroidism
3.3.10 Wilmar M. Wiersinga: Graves orbitopathy and dermopathy
3.3.11 Dagmar Fuhrer and Holger Jaschke: Management of toxic multinodular goitre and toxic adenoma
3.3.12 Wilmar M. Wiersinga: Management of thyrotoxicosis without hyperthyroidism
3.4 Hypothyroidism
3.4.1 Massimo Tonacchera and Luca Chiovato: Clinical assessment and systemic manifestations of hypothyroidism
3.4.2 Ferruccio Santini: Causes and laboratory investigation of hypothyroidism
3.4.3 Leonard Wartofsky, Dorina Ylli, and Joanna Klubo-Gwiezdzinska: Myxoedema coma
3.4.4 Bijay Vaidya and Chantal Daumerie: Subclinical hypothyroidism
3.4.5 Mark Gurnell, Carla Moran, and V. K. Chatterjee: Syndromes of Resistance to Thyroid Hormone
3.4.6 Birte Nygaard: Treatment of hypothyroidism
3.5 Thyroid lumps
3.5.1 Dagmar Fuhrer and Holger Jaschke: Pathogenesis of nontoxic goitre
3.5.2 Hans Graf and Gilberto Paz Filho: Management of nontoxic multinodular goitre
3.5.3 Laszlo Hegedus and Finn N. Bennedbaek: Management of the single thyroid nodule
3.5.4 Massimo Santoro, Barbara Jarzab, Jolanta Krajewska, and Dagmara Rusinek: Pathogenesis of thyroid cancer
3.5.5 Fulvio Basolo and Clara Ugolini: Pathology of thyroid cancer
3.5.6 Corin Badiu and Ruxandra Dobrescu: Papillary, follicular, and anaplastic thyroid carcinoma and lymphoma
3.5.7 Friedhelm Raue and Karin Frank-Raue: Medullary thyroid carcinoma
4. Parathyroid, calcium, and bone metabolism
4.1 David Goltzman and Geoffrey N. Hendy: Parathyroid anatomy, hormone synthesis, secretion, action, and receptors
4.2 Claudio Marcocci, Federica Saponaro, and Filomena Cetani: Hypercalcaemia
4.3 John P. Bilezikian: Primary hyperparathyroidism
4.4 Dolores Shoback and Muriel Babey: Familial Hypocalciuric Hypercalcemia Types 1-3 and Neonatal Severe Primary Hyperparathyroidism
4.5 Rajesh Thakker, Bart Clarke, and Fadil M. Hannan: Hypocalcaemic disorders, hypoparathyroidism, and pseudohypoparathyroidism
4.6 Paul Miller, Irinel Stanciu, and Michael Pazianas: Bones and the Kidney
4.7 Laleh Ardeshirpour, Thomas O. Carpenter, and Cemre Robinson: Hypercalcaemic and hypocalcaemic syndromes in children
4.8 Richard Eastell: Osteoporosis
4.9 Graham R. Williams, J. H. Duncan Bassett, Bernard Freudenthal, and Laura M. Watts: Thyroid disorders and bone disease
4.10 Socrates E. Papapoulos: Paget s disease of bone
4.11 Michael P. Whyte: Rickets and osteomalacia (acquired and heritable forms)
4.12 Gherardo Mazziotti, Ernesto Canalis, and John P. Bilezikian: Glucocorticoid-induced osteoporosis
5. The adrenal gland and endocrine hypertension
5.1 Peter Guest: Adrenal imaging
5.2 Fausto Palazzo and Radu Mihai: Adrenal surgery
5.3 Irina Bancos, Massimo Terzolo, and Wiebke Arlt: Adrenal incidentaloma
5.4 Jerome Bertherat, Rossella Libe, and Anne Jouinot: Adrenocortical cancer
5.5.1 Eamonn R. Maher and Ruth T Casey: Genetics of phaeochromocytomas, paragangliomas, and neuroblastoma
5.5.2 Henri Timmers: Management of phaeochromocytoma and paragagnlioma
5.6.1 Maria Christina Zennaro, Fabio Fernandes-Rosa, and Sheerazed Boulkroun: Genetics of primary aldosteronism and other steroid-related causes of endocrine hypertension
5.6.2 Morris Brown and Will Drake: Management of primary aldosteronism
5.7 John Newell-Price: Cushing s syndrome
5.8.1 Li Chan and Shwetha Ramachandrappa: Genetics of Adrenal Insufficiency
5.8.2 Wiebke Arlt: Management of Adrenal Insufficiency
5.9.1 Nils P. Krone: Genetics of congenital adrenal hyperplasia
5.9.2 Richard J. Auchus: Modern management of congenital adrenal hyperplasia and prospects for the future
6. Neuroendocrine tumours and genetic disorders
6.1 Guido Rindi and Rajaventhan Srirajaskanthan: Overview and Pathophysiology of Neuroendocrine Neoplasms
6.2 Whaljit Dhillo and Paul Bech: Neuroendocrine tumour markers
6.3 Rajaventhan Srirajaskanthan, Martyn E. Caplin, and Dominique Clement: Carcinoid syndrome
6.4.1 Juan W. Valle, Kok Haw Jonathan Lim, and Wasat Mansoor: Lung neuroendocrine tumours
6.4.2 Juan W. Valle, Kok Haw Jonathan Lim, and Wasat Mansoor: Non-functioning pancreatic neuroendocrine tumours
6.5 Christos Toumpanakis and Martyn E. Caplin: Gastrinoma
6.6 Ashley Grossman and Ingrid YF Mak: Insulinoma and hypoglycaemia
6.7 Karim Meeran: Glucagonoma
6.8 Alia Munir: Vasointestinal Polypeptide Secreting Tumours
6.9 John Wass: Somatostatinoma
6.10 Prakash Manoharan: Imaging neuroendocrine tumours of the gastrointestinal tract/gastroenteropancreatic neuroendocrine tumours (GEP-NET)
6.11 Rajesh V. Thakker: Multiple endocrine neoplasia type 1
6.12 Electron Kebebew, Douglas Wiseman, and Mustapha El Lakis: Multiple endocrine neoplasia type 2a and 2b
6.13 Eamonn R. Maher and Ruth T. Casey: Familial syndromes and genetic causes of paraganglioma and phaeochromocytoma
6.14 Constantine A. Stratakis and Fabio Faucz: Carney s complex
6.15 Michael A. Levine and Steven A. Lietman: Molecular and Clinical Characteristics Of the McCune-Albright Syndrome
6.16 Charis Eng, Lamis Yehia, and Shreya Malhotra: Cowden syndrome
7. Growth and development during childhood and adolescence
7.1 Growth and its Disorders
7.1.1 Gary Butler: Recognising Normal and Disordered Growth
7.1.2 Alexander A. L. Jorge, Fernanda A. Correa, and Renata C. Scalco: Disorders of the GH-IGF Axis
7.1.3 Anita Hokken-Koelega: Short stature in children born small for gestational age
7.1.4 Steve Chernausek and Minu George: Growth Disorders with no defined aetiology
7.1.5 Lars Savendahl and Emelie Benji: Tall Stature
7.2 Sex Development
7.2.1 Olaf Hiort and Ralf Werner: Sex Determination and Differentiation
7.2.2 S. Faisal Ahmed and Salma R. Ali: Disorders of Sex Development (DSD) in the newborn
7.2.3 Alan Rogol and John Fuqua: Recognising Normal and Disordered Pubertal Development
7.2.4 Alan Rogol and John Fuqua: Pubertal Delay and Hypogonadism
7.2.5 Julianne Leger and Jean-Claude Carel: Precocious Puberty
7.3 Helena Gleeson and Rohana Wright: Transition In Endocrinology
8. Female endocrinology and pregnancy
8.1 Normal female endocrinology and ovarian disorders
8.1.1 Chris McCartney and John Marshall: Neuroendocrinology of reproduction: the role of hypothalamus and pituitary
8.1.2 Terhi Piltonen and Juha Tapanainen: Ovarian and uterine development from fetal life to puberty
8.1.3 Gurkan Bozdag, Baris Ata, and Engin Turkgeldi: Menstrual cycle and ovulation
8.2 Evaluation of the female patient with suspected reproductive endocrine disorders
8.2.1 Channa Jayasena, Steve Franks, and Rachel Roberts: Clinical evaluation of patient with suspected reproductive endocrine disorders
8.2.2 Daniel Dumesic and Zain Al-Safi: Laboratory evaluation
8.3 Reproductive endocrine disorders
8.3.1 Sarah L. Berga: Disorders of gonadotrophin secreton
8.3.2 Julian R. E. Davis and Agnieszka Swiecicka: Hyperprolactinaemia
8.3.3 Deepthi Lavu, Radha Indusekhar, and Shaughn O'Brien: Premenstrual syndrome
8.4 Polycystic ovary syndrome and other androgen excess disorders
8.4.1 Bulent Yildiz and Sezcan Mumusoglu: Polycystic ovary syndrome: definitions, phenotypes, prevalence and genetics
8.4.2 R Jeffrey Chang: Polycystic ovary syndrome: reproductive aspects
8.4.3 David Ehrmann and Susan Sam: Polycystic ovary syndrome: metabolic aspects
8.4.4 Duarte Pignatelli, Ricardo Azziz, and Bulent Yildiz: Polycystic ovary syndrome: Hirsutism
8.5 Female hypogonadism and menopause
8.5.1 Ephia Yasmin and Gerard S. Conway: Female hypogonadism: premature ovarian insufficiency
8.5.2 Dimitrios G. Goulis, Stavroula A. Paschou, and Panagiotis Anagnostis: Female hypogonadism: Endocrinology of the menopause and hormone replacement therapy
8.6 Female infertility
8.6.1 Adam Balen and Susie Jacob: Female Infertility and assisted reproduction
8.6.2 Kutluk Oktay and Enes Taylan: Female infertility: fertility preservation
8.7 Hormonal contraception
8.7.1 Jennifer Chin Bliss Kaneshiro: Hormonal contraception
8.8 Exogenous factors and female repoductive health
8.8.1 Alessandra Gambineri and Daniela Ibarra-Gasparini: Exogenous factors and female reproductive health: common extragonadal endocrinopathies affecting reproduction
8.8.2 Siew Lim, Aya Mousa, Soulmaz Shorakae, and Lisa Moran: Exogenous factors and female reproductive health: nutrition and reproduction
8.8.3 Evy Diamanti-Kandarakis and Eleni A Kandaraki: Exogenous factors and female reproductive health: envrionment and reproduction
9. Endocrinology of pregnancy
9.1 Endocrine disorders of Pregnancy
9.1.1 Peter Taylor, LDKE Premawardhana, and John Lazarus: General considerations relating to thyroid disease in pregnancy
9.1.2 Kris Poppe, Flora Veltri, and David Unuane: Management of thyroid disorders before assisted and spontaneous pregnancy
9.1.3 Tim Korevaar and Robin Peeters: Thyroid disease during pregnancy
9.1.4 Nobuyuki Amino and Naoko Arata: Management of thyroid disorders after pregnancy
9.1.5 A. S. Paul van Trotsenburg Nitash and Zwaveling-Soonawala: Thyroid disorders in newborns, infants and children
9.1.6 Mark Molitch and Wenyu Huang: Pituitary tumours in pregnancy
9.1.7 Paul Carroll, Niki Karavitaki, and Kirstie Lithgow: Other disorders of the pituitary and hypothalamus in pregnancy
9.1.8 David Torpy, Michael O'Reilly, and Sunita De Sousa: Adrenal disease in pregnancy
9.1.9 Jeremy Cox and Stephen Robinson: Endocrine bone disease in pregnancy
9.1.10 Sandra Lowe: Imaging of endocrine disorders in pregnancy
10. Male Reproductive Endocrinology
10.1 Normal male reproductive endocrinology
10.1.1 Ilpo Huhtaniemi and Jorma Toppari: Endocrine and local regulation of testicular hormone and sperm production
10.1.2 Dirk Vanderschueren, Leen Antonio, Nari Kim, and Frank Claessens: Sex steroid actions in the Male
10.2 Evaluation of the male patient with suspected hypogonadism and/or infertility
10.2.1 Bradley Anawalt: Clinical evaluation
10.2.2 Jean-Marc Kaufman: Endocrine evaluation
10.2.3 Jackson Kirkman-Brown and Sarah J Conner: Diagnostic Semen analysis
10.3 Male reproductive endocrine disorders
10.3.1 Claus H. Gravholt: Klinefelter s syndrome
10.3.2 Adult Hypogonadism: Aetiology Alvin Matsumoto and Radhika Narla: Etiology of Hypogonadism Giovanni Corona, Mario Maggi, and Giulia Rastrelli: Types of Treatments Michael Zitzmann: Gonadotrophin induction of spermatogenesis Shehzad Basaria and Thiago Gagliano-Juca: Male Hypogonadism: Benefits of Testosterone Treatment Adrian Dobs and Swaytha Yalamanchi: Risks of T Treatment
10.3.3 Herman J. Tournaye and Biljana Popovic-Todorovic: Management of Idiopathic male infertility
10.3.4 Mathis Grossmann, B. Yeap, and Gary Wittert: Hypothalamo-pituitary-testicular axis fucntion in systemic diseases and effects of medications
10.3.5 Vincenzo Rochira, Antonio R. M. Granata, and Cesare Carani: Management of sexual dysfunction
10.3.6 Stephanie Page and Maritza Farrant: Hormonal male contraception
10.3.7 Glenn Braunstein: Gynaecomastia
10.4 Exogenous factors and male reproductive health
10.4.1 Jorma Toppari: Environmental influences on male reproductive health
10.4.2 David Handelsman: Androgen Misuse and Abuse
11. Management of the Transgender Patient
11.1 Jon Arcelus and Walter Bouman: Introduction to Transgender and Gender Diverse People
11.2 Daniel Klink: Endocrine Treatment of Transgender Youth
11.3 Vin Tangpricha and Craig Sineath: Hormone Therapy in transgender women
11.4 Guy T'Sjoen and Justine Defreyne: Hormone therapy in transgender men
11.5 Chloe De Roo and Guy T'Sjoen: Fertility Options for Transgender Persons
12. Endocrine Responses to Systemic Diseases or Substance Use
12.1 Endocrinology of systemic disease
12.1.1 David Henley, Thomas Upton, and Stafford L. Lightman: The endocrine response to stress
12.1.2 Greet Van den Berghe and Lies Langouche: Endocrinology in the critically ill
12.1.3 David Johnson, Melissa Nataatmadja, and Yeoungjee Cho: Hormones and the kidney
12.1.4 Jacob George and Mohammed Eslam: The endocrinology of liver disease
12.1.5 Steven K. Grinspoon and Takara Stanley: Endocrine abnormalities in HIV infection
12.1.6 Karen Miller: The endocrinology of anorexia nervosa
12.2 Endocrine Complications of Substance Misuse
12.2.1 Marc Walter and Margit Proescholdt: Endocrinology and alcohol
12.2.2 Peter Sonksen and Richard Holt: Use and abuse of performance-enhancing hormones in sport
12.2.3 Ashley Grossman, Eleni Armeni, and Bernard Khoo: Effect of Opioids on Adrenal and Reproductive Endocrinology
13. Endocrinology of cancer
13.1 Endocrine Disorders Caused by Cancer or its Treatment
13.1.1 Thomas Papathomas and Vania Nose: Metastatic Disease in Endocrine Organs
13.1.2 David W. Ray: Paraneoplastic endocrine syndromes
13.1.3 Claire Higham and Rob Murray: Long-term endocrine sequelae of cancer therapy
13.1.4 Carla Moran: Endocrine complications of biological cancer therapies
13.2 Hormonal therapy for breast and prostatic cancers
13.2.1 Rob Clarke and Alice Greenhalgh: The breast: lactation and breast cancer as an endocrine disease
13.2.2 Amna Sheri and Laura Morrison: Endocrine treatment of breast cancer
13.2.3 Irina A. Vasilevskaya, Matthew J. Schiewer, and Karen E. Knudsen: Hormonal Therapy for Prostate Cancer: Molecular basis of efficacy and therapeutic bypass
14. Obesity, lipids, and metabolic disorders
14.1 Obesity
14.1.1 Anthony Coll: The Physiology of Bodyweight Regulation
14.1.2 Adrian Bauman: Obesity as a Public Health Problem
14.1.3 Rachel Batterham and Friedrich Jassil: Medical Complications of Obesity
14.1.4 John Wilding and Jonathan Lim: Dietary and Medical Management of Obesity
14.1.5 Francesco Rubino, Vivian Anastasiou, Luca Ferraro, Dalal Qanaq, and Ghassan Chamseddine: Metabolic Surgery
14.1.6 Sadaf Farooqi: Assessment of Obesity in Children
14.1.7 Russell Viner and Billy White: Management of Obesity in Children and Young People
14.1.8 Nick Finer: Planning obesity care pathways
14.2 Lipoprotein metabolism and dyslipidaemia
14.2.1 Bo Angelin and Paolo Parini: Lipoprotein metabolism
14.2.2 Stefano Romeo, Bo Angelin, and Paolo Parini: Genetic forms of dyslipidaemia
14.3 Other metabolic disorders
14.3.1 Khalid Hussain and Sonya Galcheva: Hyperinsulinaemic Hypoglycaemia
14.3.2 Phillip Gorden and Noemi Malandrino: Autoimmune Hypoglycaemia
14.3.3 Robin H. Lachmann: Disorders of carbohydrate metabolism
14.3.4 Yves Deugnier and Edouard Bardou-Jacquet: Haemochromatosis And Other Inherited Diseases Of Iron Metabolism
14.3.5 Michael N. Badminton and Danja Schulenburg-Brand: The porphyrias
15. Diabetes mellitus
15.1 Introduction to Diabetes Mellitus
15.1.1 Shanta Persaud and Peter Jones: Physiology of glucose homeostasis
15.1.2 Stephen Colagiuri and Crystal Man Ying Lee: Classification and diagnosis of diabetes mellitus
15.2 Aetiopathogenesis and Diagnosis of Type 1 Diabetes
15.2.1 Elizabeth J. Mayer-Davis and Daria Igudesman: Epidemiology and Public Health
15.2.2 Augustin Brooks: Presentation and Natural History
15.2.3 Richard Oram, Susan Wong, and Ayat Bashir: Pathogenesis
15.3 Aetiopathogenesis and Diagnosis of Type 2 Diabetes
15.3.1 Sarah Wild and Jackie Price: Epidemiology and Public Health
15.3.2 Roy Taylor: Presentation and Natural History
15.3.3 Mark Walker, Xuefei Yu, and Amalia Gastaldelli: Pathogenesis
15.4 Non Type 1, Non Type 2 Diabetes
15.4.1 Katherine Owen: Diagnosis of non type 1, non type 2 forms of diabetes
15.5 Principles of Management of Diabetes
15.5.1 Simon Heller and Jackie Elliott: Structured Education
15.5.2 John Pickup and Nick Oliver: Glucose Monitoring and Sensing
15.5.3 Pratik Choudhary and Peter Jacob: Insulins and insulin delivery devices
15.5.4 Clifford Bailey and Melanie Davies: Non-insulin glucose lowering agents
15.5.5 Stephanie Amiel: Hypoglycaemia in the treatment of diabetes mellitus
15.6 Evidence-based Management of Type 1 Diabetes
15.6.1 Peter Hammond and Fiona Campbell: Strategies for management of type 1 diabetes
15.6.2 Christel Hendrieckx and Jane Speight: Psychological and Behavioural Aspects of Type 1 Diabetes Management
15.6.3 Colin Dayan and Danijela Tatovic: Immunotherapy for type 1 diabetes
15.6.4 Peter Senior, Martin Drage, Anneliese Flatt, and Chris Callaghan: Transplantation (islet and solid organ)
15.7 Evidence-based Prevention and Management of Type 2 Diabetes
15.7.1 Peter Winocour and Sagen Zac-Varghese: Strategies for management of type 2 diabetes
15.7.2 Jane Speight and Tim Skinner: Psychological and Behavioural Aspects of Type 2 Diabetes Management
15.7.3 Kamiesh Khunti and Nitin Narayan Gholap: Type 2 diabetes in different ethnic groups
15.7.4 Nicholas Wareham: Prevention of Type 2 Diabetes
15.8 Emerging Approaches to Restoring Euglycaemia in Diabetes
15.8.1 Michael White, Timothy J. Kieffer, and Cara Ellis: Regenerative medicine for diabetes
15.8.2 Roman Hovorka and Charlotte Boughton: Closed loop
15.9 Emergency and Hospital management of Diabetes
15.9.1 Ketan Dhatariya: Hyperglycaemic Emergencies
15.9.2 Gerry Rayman: Management of the inpatient with diabetes mellitus
15.9.3 Greet Van Den Berghe and Jan Gunst: Care of diabetes in ICU and peri-sugery
15.10 Specialised Management of Other forms of Diabetes
15.10.1 Andrew Hattersley, Kashyap Patel, and Rachel Besser: Monogenic forms of diabetes resulting from beta cell dysfunction
15.10.2 Anna Stears, David B. Savage, and Stephen O'Rahilly: Lipodystrophies and severe insulin resistance Phil Weston: Diabetes Secondary to Pancreatic Disease Jeremy Tomlinson: Diabetes Secondary to Endocrine Disorders
15.10.4 Helen Murphy and Jennifer M Yamamoto: Diabetes in Pregnancy
15.11 Psychiatry and Diabetes
15.11.1 Khalida Ismail, Christopher Garrett, and Marietta Stadler: Type 1 diabetes and Psychiatry
15.11.2 Khalida Ismail, Hermione Price, Marilia Calcia, Calum Moulton, and Clare Whicher: Type 2 diabetes and Psychiatry
15.12 Microvascular Complications of Diabetes
15.12.1 Angela Shore: Pathogenesis of Microvascular Complications
15.12.2 Peter Scanlon: Retinopathy
15.12.3 Luigi Gnudi and Sally Marshall: Diabetic Nephropathy
15.12.4 Solomon Tesfaye and Jing Wu: Diabetic Neuropathy
15.13 Macrovascular Disease in Diabetes
15.13.1 Mark Kearney, Peysh Patel, and Richard Cubbon: Mechanisms of macrovascular disease in diabetes
15.13.2 Naveed Sattar: Macrovascular disease in type 2 diabetes
15.13.3 John Petrie: Macrovascular disease in type 1 diabetes
15.13.4 Bruno Verges: Diabetic dyslipidaemia
15.13.5 Bryan Williams: Hypertension in diabetes mellitus
15.14 The Diabetic Foot
15.14.1 Frank Bowling and Andrew Boulton: Modern management of diabetes-related foot disease
15.15 Delivery of Diabetes Care
15.15.1 Jonathan Valabhji: Diabetes service organisation
15.15.2 Philip Clarke and Tom Lung: Health Economics of Diabetes Care and Prevention


Professor Wass is a Professor of Endocrinology at Oxford University and was the Head of the Department of Endocrinology at the Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital Oxford, UK until 2011. From 1989 he was Professor of Clinical Endocrinology and Sub-Dean, University of London at Bart's. He founded and ran the Oxfordshire Osteoporosis Service in 1995. John Wass is currently the Clinical Reference Group Chair for Endocrinology in the UK. He was President of the European Federation of Endocrine Societies from 2001-2203 and was Chairman of the Society for Endocrinology (2006-2009). He was awarded the Distinguished Physician of the Year Award by the American Endocrine Society, the first non-American to ever receive this award Elected Academic Vice President of the Royal College of Physicians London in 2012 he has chaired the Royal College of Physicians Working Party 'Action on Obesity: Comprehensive Care for All' published in January 2013.; Wiebke Arlt qualified at the University of Cologne in 1990. She trained in Endocrinology from 1994 to 1998 under the auspices of Professor Bruno Allolio at the University Hospital Wurzburg, Germany. She then spent two years in the Molecular Endocrinology Lab of the Department of Paediatrics at the University of California in San Francisco (UCSF), hosted by Walter Miller. Following her return to Wuerzburg in 2001 she was appointed Consultant Endocrinologist. She obtained a prestigious Heisenberg Fellowship from the German Research Council and moved to Birmingham in October 2002. In 2004, she obtained an MRC Senior Clinical Fellowship and was appointed Senior Lecturer at the University of Birmingham. Promotion to Chair of Medicine in 2006 and to Head of the Centre for Endocrinology, Diabetes and Metabolism in 2008. She was awarded the William Withering Chair of Medicine in 2014 and appointed as Director of the newly founded Institute of Metabolism and Systems Research in 2015.; Professor Semple is an endocrinologist based at the University of Edinburgh, where he is also Dean of Postgraduate Research for the College of Medicine and Veterinary Medicine. His interests include insulin resistance, diabetes, hypoglycaemia and mosaic growth disorders, in each of which he engages in fundamental molecular and cellular research, translational studies, and clinical practice.