Field Trials of Health Interventions: A Toolbox (3rd edition)

ISBN : 9780198732860

Peter G. Smith; Richard H. Morrow; David A. Ross
480 ページ
170 x 234 mm

This is an open access title available under the terms of a CC BY-NC 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in 'field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this manual, practical issues in trial design and conduct are discussed fully and in sufficient detail, that Field Trials of Health Interventions may be used as a 'toolbox' by field investigators. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience. Available as an open access book via Oxford Medicine Online, this new edition is a comprehensive revision, incorporating the new developments that have taken place in recent years with respect to trials, including seven new chapters on subjects ranging from trial governance, and preliminary studies to pilot testing.


1. Introduction
2. Types of intervention and their development
3. Reviewing the literature
4. Study design
5. Study size
6. Ethical considerations
7. Trial governance
8. Preparing grant applications
9. Community engagement
10. Censuses and mapping
11. Randomisation, blinding and coding
12. Outcome measures and case definition
13. Preliminary studies and pilot testing
14. Questionnaires
15. Social and behavioural research
16. Field organization and ensuring data of high quality
17. Field laboratory methods
18. Budgeting and accounting
19. Intervention costing and economic analysis
20. Data management
21. Methods of analysis
22. Phase IV studies
23. Reporting and using trial results


Peter G. Smith, Medical Research Council Tropical Epidemiology Group London School of Hygiene and Tropical Medicine London, UK; Richard H. Morrow, Division of Health Systems, Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, USA; David A. Ross, Medical Research Council Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK