Ovarian Cancer Immunotherapy

ISBN : 9780190248208

Samir A. Farghaly
256 ページ
178 x 254 mm

Ovarian Cancer Immunotherapy provides a broad overview of several aspects of basic sciences, and clinical and therapeutic aspects of immunotherapy for ovarian cancer, as well as state-of-the-art information on molecular genetics and biology. Chapters are written by a team of expert contributors from around the world and explore topics such as antibody therapeutics for ovarian carcinoma, emerging serum biomarkers, ovarian cancer immunity, adoptive cell immunotherapy, the biology of dendritic cells, the role of growth factors, and more. Readers will also gain a better understanding of the molecular and cellular events that underlie ovarian cancer immunology. This book is an ideal resource for clinicians, basic medical scientists, graduate basic medical science students, and medical students caring for patients with ovarian cancer, including attending surgeons and physicians, and clinical fellows and residents in the disciplines of gynecologic oncology, medical oncology, and surgical oncology.


Chapter 1: Antibody Therapeutics for Ovarian Carcinoma and Translation to the Clinic
Debra H. Josephs, Heather J. Bax, Giulia Pellizzari, James F. Spicer, Ana Montes, and Sophia N. Karagiannis
Chapter 2: Biological Aspects and Clinical Applications of Serum Biomarkers in Ovarian Cancer
Rouba Ali- Fehmi and Eman Abdulfatah
Chapter 3: Ovarian Cancer Immunity: How Does Immune Suppression Grow Cancer?
Vincent Lavoue, Patrick Legembre, Jean Leveque, Fabrice Foucher, Sebastien Henno, and Florian Cabillic
Chapter 4: Ovarian Tumor Microenvironment and Innate Immune Recognition
Jocelyn Reader, Sarah Lynam, Amy Harper, Gautam Rao, Maya Matheny, and Dana M. Roque
Chapter 5: Adoptive Cell Immunotherapy for Epithelial Ovarian Cancer
Samir A. Farghaly
Chapter 6: Antibody-based Therapy for Ovarian Cancer
Yousef Alharbi, Manish S. Patankar, and Rebecca J. Whelan
Chapter 7: Epitope/Peptide-based Monoclonal Antibodies for Immunotherapy of Ovarian Cancer
Gregory Lee
Chapter 8: Dendritic Cell Vaccine Therapy for Ovarian Cancer
Caitlin Stashwick, Brian J. Czerniecki, Janos L. Tanyi
Chapter 9: Heat Shock Protein Vaccine Therapy for Ovarian Cancer
Hiroyuki Abe, Amane Sasada, Shigeki Tabata, Hiroaki Kawasaki, and Minako Abe
Chapter 10: PD-1 /PDL-1 Inhibitors as Immunotherapy for Ovarian Cancer
Scott Moerdler and Xingxing Zang
Chapter 11: Growth Factors and Their Corresponding Receptors as Targets for Ovarian Cancer Therapy
Anca Maria Cimpean, Andreea Adriana Jitariu, and Marius Raica
Chapter 12: Unique Challenges Facing Immunotherapy of Metastatic Ovarian Cancer
Michelle N. Messmer, Colleen S. Netherby, and Scott I. Abrams
Chapter 13: Clinical Trials of Ovarian Cancer Immunotherapy and Future Directions
Justin M. Drerup, Curtis A. Clark, and Tyler J. Curiel


Samir A. Farghaly, MD, PhD is a Professor Obstetrics and Gynecology at the Joan and Sanford I. Weill Medical College, Graduate School of Medical Sciences; Sandra and Edward Meyer Cancer Center; and New York-Presbyterian Hospital/Weill Cornell Medical Center in New York, NY. He received his MD and PhD in molecular biology from London University. Dr. Farghaly is the Founder and Editor-in Chief of Current Trends in Gynecologic Oncology, and The International Journal of Gynecological, Obstetrical, and Reproductive Medicine Research. He is a member of the editorial boards of 18 international medical journals on Gynecological Cancers, Gene Expression and Therapy, Women's Health, and Gynecology.