50 Studies Every Intensivist Should Know

ISBN : 9780190467654

Edward A. Bittner
352 ページ
156 x 235 mm

50 Studies Every Intensivist Should Know presents key studies that have shaped the practice of critical care medicine. Selected using a rigorous methodology, the studies cover topics including: sedation and analgesia, resuscitation, shock, ARDS, nutrition, renal failure, trauma, infection, diabetes, and physical therapy. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. An illustrative clinical case concludes each review, followed by brief information on other relevant studies. This book is a must-read for health care professionals and anyone who wants to learn more about the data behind clinical practice. While clinicians in the intensive care unit increasingly rely on practice guidelines that take into account the best available published research data, sorting through the studies efficiently, and separating the good from the not-so-good is a daunting task even for seasoned practitioners, much less trainees. This superb effort by Dr. Bittner and his group of extremely accomplished and experienced clinicians is a huge step in the right direction. 50 Studies Every Intensivist Should Know provides an excellent list of the landmark studies in the arena of critical care medicine and should be required reading for all our residents and critical care fellows. Hasan B. Alam, MD Norman Thompson Professor and Head of General Surgery University of Michigan


Section 1: Neurologic, Sedation, and Analgesia; Chapter 1: Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest: The HACA trial; Ala Nozari; Chapter 2: Decompressive Craniectomy in Diffuse Traumatic Brain Injury: The DECRA Trial; Merrick E. Miles and Avinash B. Kumar; Chapter 3: Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation; David Stahl; Chapter 4: A comparison of four treatments for generalized convulsive status epilepticus; Jason L. Sanders and Jarone Lee; Chapter 5: Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care: a randomised controlled trial (Awakening and Breathing Controlled Trial); Jeffery Katz and Steve Greenberg; Chapter 6: A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomized trial; Ulrich Schmidt and Zeb McMillan; Chapter 7: Intracranial Pressure Monitoring in Severe Traumatic Brain Injury; Thomas Peponis and David R. King; Section 2: Cardiovascular, Resuscitation, Shock; Chapter 8: Early Goal-Directed Therapy in the treatment of severe sepsis and septic shock: The EGDT trial; Namita Jayaprakash and Joseph Hyder; Chapter 9: Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy; Marc de Moya and Leandra Krowsoski; Chapter 10: Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis: The PROWESS Study; Anna M. Ward and Richard M. Pino; Chapter 11: Saline Versus Albumin for Resuscitation of Critically Ill Adults: The SAFE Study; Craig S. Jabaley; Chapter 12: The Use of the Pulmonary Artery Catheter in Critical Care: The PAC-Man Trial; Shahzad Shaefi and Ameeka Pannu; Chapter 13: Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock: The VASST Trial; Karim Fikry; Chapter 14: Comparison of dopamine and norepinephrine in the treatment of shock: The SOAP II Trial; Daniel W. Johnson; Chapter 15: CPR with Chest Compression Alone or with Rescue Breathing; Christopher Kit Tainter and Gabriel Wardi; Chapter 16: Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist Device; David M. Dudzinski and James Sawalla Guseh; Chapter 17: Intraaortic Balloon Support in Myocardial Infarction Complicated by Cardiogenic Shock; David M. Dudzinski and Sam Bernard; Chapter 18: Angioplasty vs. Fibrinolytics in Acute ST-Elevation Myocardial Infarction: The DANAMI-2 Trial; Bryan Simmons; Section 3: Pulmonary, ARDS; Chapter 19: The Acute Respiratory Distress Syndrome Network: Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome; Laleh Jalilian and Jeanine Wiener Kronish; Chapter 20: Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome; Duncan McLean and Matthias Eikermann; Chapter 21: Prone Positioning in Severe Acute Respiratory Distress Syndrome: The PROSEVA trial; Andrea Coppadoro and Giuseppe Foti; Chapter 22: Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial; Matthew James Sigakis; Chapter 23: Comparison of Two Fluid-Management Strategies in Acute Lung Injury: The FACTT Trial; Ross Gaudet and Rebecca Kalman; Chapter 24: Positive End-Expiratory Pressure Setting in Adults with ALI and ARDS: The ExPress Trial; J. Aaron Scott and Vivek Moitra; Chapter 25: Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome; Ednan Bajwa and Sean Levy; Chapter 26: Effect of Early Vs. Late Tracheostomy Placement on Survival in Patients Receiving Mechanical Ventilation: The TRACMAN Trial; J. Michael Guthrie and Vadim Gudzenko; Chapter 27: Using Esophageal Pressures to Improve Oxygenation and Compliance in Acute Lung Injury; Connie Wang and Edward Bittner; Chapter 28: A comparison of four methods of weaning patients from mechanical ventilation; Sheri Berg and Archit Sharma; Chapter 29: Noninvasive Ventilation for Acute COPD Exacerbations; Robert Loflin and David Kaufman; Chapter 30: High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome; Susan Wilcox and Haitham Al Ashry; Section 4: Gastrointestinal/Nutrition; Chapter 31: Risk Factors for Gastrointestinal Bleeding in Critically Ill Patients; Miguel Cobas and Melissa Grillo; Chapter 32: Early vs. Late Parenteral Nutrition in the ICU: The EPaNIC (Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients) Trial; D. Dante Yeh; Chapter 33: Initial Trophic vs Full Enteral Feeding in Patients With Acute Lung Injury: The EDEN Randomized Trial; Milad Sharifpour and Pedro Mendez-Tellez; Chapter 34: Early versus On-Demand Nasoenteric Tube Feeding in Acute Pancreatitis; Peter J. Fagenholz; Chapter 35: Glutamine and Antioxidants in Critically Ill Patients: The Redoxs Trial; Yuk Ming Liu and Jarone Lee; Section 5: Renal; Chapter 36: Low-Dose Dopamine in Patients with Early Renal Dysfunction; Tao Shen; Chapter 37: Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury; Eric Ehieli and Yuriy Brohnsteyn; Chapter 38: Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trail.; Christina Anne Jelly and Edward Bittner; Section 6: Hematologic; Chapter 39: A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care: The Transfusion Requirements in Critical Care (TRICC) Trial; Joseph R. Guenzer and Andrew Vardanian; Chapter 40: Reducing Mortality Among Bleeding Trauma Patients with Tranexamic Acid: The CRASH-2 (Clinical Randomization of an Antifibrinolytic in Significant Haemorrhage-2) Randomized Controlled Trial; Haytham M.A. Kaafarani; Chapter 41: Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ration and mortality in patients with severe trauma: The PROPPR randomized clinical trial; Yuk Ming Liu amd Kathryn Butler; Section 7: Infectious; Chapter 42: Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial.; Laurie O. Mark and Jean Kwo; Chapter 43: Bronchoscopy with Bronchoalveolar Lavage vs. Endotracheal Aspiration for the Diagnosis of Ventilator Associated Pneumonia; Samad Rasul and David C. Kaufman; Chapter 44: Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia; Kimberly Pollock and Angela Meier; Chapter 45: Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial; Alice Gallo De Moraes and Dante Schiavo; Chapter 46: Nasopharyngeal and Oropharyngeal Decontamination to Prevent Nosocomial Infection in Cardiac Surgery Patients; Jose L. Diaz-Gomez and Sarah W. Robison; Chapter 47: An intervention to decrease catheter-related bloodstream infections in the ICU: The Keystone ICU Project; Courtney Maxey-Jones and Edward Bittner; Section 8: Endocrine; Chapter 48: The Normoglycemia in Intensive Care Evaluation-Survival Using Glucose Algorithm Regulation (NICE-SUGAR) Trial; Daniel J. Niven and Tom Stelfox; Chapter 49: Hydrocortisone Therapy for Patients with Septic Shock: The CORTICUS Trial; Ryan J. Horvath and Edward Bittner; Section 9: Musculoskeletal; Chapter 50: Daily interruption of sedation with physical and occupational therapy in mechanically ventilated patients; Michael Wolfe and Daniel Saddawi-Konefka


Dr. Edward Bittner, MD, PhD is an anesthesiologist and critical care physician at the Massachusetts General Hospital, where he serves as Program Director for the Critical Care Medicine Fellowship and Associate Director of the Surgical Intensive Care Unit. He is also an Associate Professor of Anesthesiology at Harvard Medical School. He earned his PhD in biostatistics from Tulane University, medical degree from Mount Sinai School of Medicine, and a master's degree in Medical Education from the University of Pennsylvania. Dr. Bittner has broad academic and research interests that combine his background in biostatistics and education with his clinical expertise of anesthesiology and critical care. He has published over 150 original articles, reviews, chapters, and editorials in high impact journals and authoritative textbooks. He has also edited nine widely used books in anesthesiology and critical care.