Obsessive-compulsive Disorder: Phenomenology, Pathophysiology, and Treatment

ISBN : 9780190228163

Christopher Pittenger
784 ページ
216 x 279 mm

Obsessive-compulsive disorder affects approximately one person in 40 and causes great suffering. Effective treatments are available that can help many, and our understanding of the psychology, neurobiology, and clinical treatment of the disorder has advanced dramatically over the past 25 years. Nevertheless, much remains to be learned, and a substantial minority of patients benefit little even from the best treatments we have to offer today. This volume provides the first comprehensive summary of the state of the field, summarizing topics ranging from genetics and neurobiology through cognitive psychology, clinical treatment, related conditions, societal implications, and personal experiences of patients and clinicians. This book is unique in its comprehensive coverage that extends far beyond the realm of cognitive-behavioral therapy. As such it will serve as a valuable introduction to those new to the field, a fascinating resource for OCD suffers and their families, and an essential reference for students, clinicians, and researchers.


1. Introduction: Narratives of OCD - Elias Aboujaoude and Christopher Pittenger

Section 1: Clinical Presentation and Diagnosis
2. Clinical Presentation of OCD - Fred Penzel
3. Pediatric OCD: Clinical Course, Phenomology, and Assessment - Rachel E. Ginsberg, Samantha Morrison, and Anthony Puliafico
4. Epidemiology, Comorbidity, and Burden of OCD - Albina R. Torres, Leonardo F. Fontenelle, Roseli G. Shavitt, Marcelo Q. Hoexter, Christopher Pittenger, and Euripedes C. Miguel
5. Natural History and Long-Term Outcome of OCD - Michael H. Bloch
6. Quality of Life and Psychosocial Functioning in OCD - Christina L. Boisseau, Carly M. Schwartzman, and Steven A. Rasmussen
7. Psychodynamic perspectives on OCD - Robert A. King

Section 2: Phenomenology and Cognitive Psychology
8. Symptom heterogeneity in OCD: A dimensional approach - Maria Concei Conceicao do Rosario, Marcelo Batistutto, and Ygor Ferrao
9. Incompleteness and harm avoidance - Stefano Pallanti, Jennifer Barnes, Christopher Pittenger, and Jane Eisen
10. Disgust and OCD - Lauren Mancusi & Dean McKay
11. Sensory Processing and Intolerance in OCD - Stephanie J. Grimaldi, and Emily R. Stern
12. Scrupulosity and Slowness in OCD: Perfectionism as a Central Mechanism - Rachel Ojserkis and Dean McKay
13. Variable Insight in OCD - Rebecca J. Hamblin, Jennifer Moonjung Park, Monica S. Wu, and Eric A. Storch
14. Clinical Rating Scales for OCD - Joseph F. McGuire, Eric A. Storch, and Wayne Goodman
15. Neuropsychosocial Function in OCD - Amitai Abramovitch
16. Habits and Goals in OCD - Claire M. Gillan
17. Intolerance of Uncertainty in Obsessive-Compulsive Disorder - Ryan J. Jacoby and Jonathan S. Abramowitz
18. Pathological responsibility, thought-action fusion, and thought control in OCD - Christine Purdon

Section 3: Biological Underpinnings
19. Genetics Of OCD - Paul Arnold
20. Neurocircuitry underlying OCD : neural networks underlying reward and action selection - Suzanne N. Haber
21. A review and synthesis of functional neuroimaging studies of OCD - Brian P. Brennan and Scott L. Rauch
22. Functional Imaging Studies of OCD: A Hypothesis-Driven Review - M.M. Vaghi and T.W. Robbins
23. The Structure of the OCD Brain - Premika S.W. Boedhoe and Odile A. van den Heuvel
24. Brain Functional Connectivity in OCD - Carles Soriano-Mas and Ben J. Harrison
25. Neurotransmitter dysregulation in OCD - Ilse Graat, Martijn Figee, and Damiaan Denys
26. Neuropeptides in OCD - Anahid Kabasakalian, Eric Hollander
27. Influence of sex hormones on OCD - Valeria Guglielmi, Judith Souget, Wouter van Elzelingen, Ingo Willuhn, and Nienke Vulink
28. PANDAS as a Post-Streptococcal Autoimmune Neuropsychiatric Form of OCD - Susan E. Swedo, Kyle A. Wiliams

Section 4: Animal Studies
29. Animal models of OCD: A conceptual framework - Christopher Pittenger, Stephanie Dulawa, and Summer L. Thompson
30. Extinction of conditioned fear and avoidance: Relevance for OCD - Jose Rodriguez-Romaguera and Gregory J. Quirk
31. OCD as a failure to integrate goal-directed and habitual action control - Laura Bradfield, Richard Morris, and Bernard W. Balleine
32. Spontaneously Occurring Animal Models of OCD - Nicholas H. Dodman and Louis Shuster
33. Mutant Mouse Models of OCD - Louis Y. Tee and Guoping Feng
34. Targeted circuit manipulations in the modeling of OCD - Susanne E. Ahmari
35. Pharmacological and behavioral rodent models of OCD - Summer L. Thompson and Stephanie C. Dulawa

Section 5: Treatment
36. Overview of the treatment of OCD - H. Blair Simpson
37. Exposure and Response Prevention in OCD - Jonathan S. Abramowitz
38. Cognitive Therapy for OCD - Maureen Whittal
39. Mindfulness and Acceptance Therapies for Obsessive-Compulsive and Related Disorders - Kate L. Morrison, Brooke M. Smith, and Michael P. Twohig
40. Standard Evidence-Based Pharmacological Treatment for OCD - Jemma E. Reid, Samar Reghunandanan, Ann Roberts, and Naomi A. Fineberg
41. The pharmacological treatment of refractory OCD - Christopher Pittenger
42. Treatment of Pediatric OCD - S. Evelyn Stewart and Clare Bleakley
43. Family accommodation in OCD: Prevalence, impact, and clinical implications - Kristin Koller and Eli R. Lebowitz
44. Nutraceutical and alternative treatments for Obsessive compulsive and Related Disorders - David Camfield and Jerome Sarris
45. Functional Neurosurgery in Severe and Treatment-Refractory OCD - Erica C. Keen, Alik S. Widge, and Darin D. Dougherty
46. Deep Brain Stimulation for Intractable OCD - Wayne K. Goodman, Nigel Kennedy, Kyle Lapidus, and Brian H. Kopell
47. Intensive Treatment Approaches for OCD - Joshua M. Nadeau, Bradley C. Riemann, and Eric Storch

Section 6: OCD-Related Disorders
48. Obsessive-Compulsive and Related Disorders: A New Category in DSM-5 - Katharine A. Phillips
49. Clinical Features, Assessment, and Treatment of body Dysmorphic Disorder - Lisa Zakhary, Hilary Weingarden, Alexandra Sullivan, and Sabine Wilhelm
50. Body Dysmorphic Disorder: Neurobiology and Genetics - Jamie D. Feusner and Danyale McCurdy-McKinnon
51. Trichtillomania and skin picking disorder - Jon E. Grant, Sarah A. Redden, Eric W. Leppink
52. Hoarding Disorder: Clinical presentation and treatment - Randy O. Frost, Lucy Graves, Elizabeth Atkins
53. Comorbidity in Pediatric OCD: Tourette Syndrom - Michael H. Bloch

Section 7. Comorbidity
54. Mood and Anxiety Disorder Comorbidity in OCD - L. Baer, A. Fang, N.C. Berman, and W.E. Minichiello
55. Psychological Trauma Exposure and Obsessive-Compulsive symptoms - Dean McKay and Rachel Ojserkis
56. Eating Disorder Comorbidity with OCD - Marina Gershkovich, Olivia Pasucci, and Joanna Steinglass
57. Obsessive-Compulsive Symptoms in Schizophrenia: Clinical features, neurobiological correlates and treatment - Michael Poyurovsky
58. Differentiating Autism Spectrum disorder and OCD - Robert E. Accordino, W. Philip Bartel, Isobel W. Green, Christen L. Kidd, and Christopher J. McDougle
59. Personality Pathology in OCD: Comorbidity and Contrast with OCPD and Other Personality Disorders - Michael G. Wheaton and Anthony Pinto

Section 8: Special Topics
60. Etiological models of OCD: anxiety, obsession, compulsion, completeness - Christopher Pittenger, Patricia Gruner, Thomas A. Adams, Benjamin Kelmendi
61. Evolutionary Perspectives of OCD - Gerrit I. van Schalkwyk and James F. Leckman
62. Research Domain Criteria and OCD: An oxymoron? - Eyal Kalanthroff, Gideon E. Anholt, and Helen Blair Simpson
63. OCD in Ethnoracial Minorities: Symptoms, barriers to care, and cultural considerations for treatment - Monnica T. Williams and Terence Ching
64. OCD in the Educational Setting - Allen H. Weg
65. The integration of new technological approaches in OCD care - Seth Feuerstein
66. OCD, Advocacy, and Addressing Stigma - Jeff Szymanski, Carly Bourne
67. Living with OCD - Elizabeth McIngvale


Christopher Pittenger is Director of the Yale OCD Research Clinic and Associate Professor of Psychiatry at Yale University. He trained at Columbia University, where he both received his medical degree and completed his Ph.D. with Nobel Prize winner Eric Kandel. He then completed his clinical training in psychiatry at Yale, where he joined the faculty in 2007. Dr. Pittenger lives outside New Haven, CT, with his wife, four children, three cats, and six chickens.