OXFORD UNIVERSITY PRESS

The Deeper Genome: Why There is More to the Human Genome Than Meets the Eye

ISBN : 9780198813095

参考価格(税込): 
¥2,002
著者: 
John Parrington
ページ
400 ページ
フォーマット
Paperback
サイズ
129 x 196 mm
刊行日
2017年08月
メール送信
印刷
  • Gives an up-to-date account of our understanding of the human genome in over a decade since the completion of the Human Genome Project
  • Reveals the emerging picture of a genome far more complex than originally thought
  • Discusses the latest research, including much debated findings of the international ENCODE project
  • Reassesses what we are learning about the uniqueness of humans, and the role of genes in 

  
Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought — just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? 
   
Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

目次: 

Introduction: How the Genome Lost Its Junk
1: The Inheritors
2: Life as a Code
3: Switches and Signals
4: The Spacious Genome
5: RNA Out of the Shadows
6: It's a Jungle in There!
7: The Genome in 3D
8: The Jumping Genes
9: The Marks of Lamarck
10: Code, Non-Code, Garbage, and Junk
11: Genes and Disease
12: What Makes us Human?
13: The Genome That Became Conscious
Conclusion: The Case for Complexity
Glossary
Notes
Index

著者について: 

John Parrington, Associate Professor and University Lecturer in Cellular & Molecular Pharmacology, University of Oxford
  
John Parrington is an Associate Professor in Molecular and Cellular Pharmacology at the University of Oxford, and a Tutorial Fellow in Medicine at Worcester College, Oxford. He is the author of Redesigning Life (Oxford University Press, 2016), and has published over 80 peer-reviewed articles in science journals including Nature, Current Biology, Journal of Cell Biology, Journal of Clinical Investigation, The EMBO Journal, Development, Developmental Biology, and Human Reproduction. He has extensive experience writing popular science, having published articles in The Guardian, New Scientist, Chemistry World, and The Biologist. As a British Science Association Media Fellow he worked as a science journalist at The Times for 7 weeks where he published 22 articles. He has also written science reports for the Wellcome Trust, British Council, and Royal Society.

"A lively and engaging popuar science book... I recommend it." - Terry Sullivan, International Socialism
  

"It's a game-changer and a masterpiece for anyone interested in biology " - Times Higher Education, Charalambos P Kyriacou
  

"... a good primer on the subtlety and complexity of the genome, especially the human genome, new facets of which emerge on a regular basis from labs around the world. " - The Scientist, Bob Grant
  

"The Deeper Genome... provides an elegant, accessible account of the profound and unexpected complexities of the human genome, and shows how many ideas developed in the 20th century are being overturned. " - New Scientist, Clare Ainsworth
  

"A compelling book that will enrich your knowledge of genetics and its potential. " - New York Journal of Books
  

"Overall, this is a faithful, engaging portrait of the twenty-first-century genome " - Nature, Nathaniel Comfort
  

"This is a brilliant book - a wonderfully entertaining history of molecular biology and the surprises and controversies of a field still very much in flux, from early explorations to the emerging realisation that the human genome may be far more sophisticated than we ever imagined. " - John Mattick, Director, Garvan Institute of Medical Research

このページに掲載の「参考価格」は日本国内における希望小売価格です。当ウェブサイトでのご購入に対して特別価格が適用される場合、販売価格は「割引価格」として表示されます。なお、価格は予告なく変更されることがございますので、あらかじめご了承ください。