Homeostatic Control of Brain Function

ISBN : 9780199322299

Detlev Boison; Susan A. Masino
656 ページ
189 x 256 mm

Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Featur



Part I: Homeostatic Regulators: Molecules and Ions
Chapter 1: Microdynamics of water and ion homeostasis in the brain: role of aquaporins and ion channels of astroglial cells
Chapter 2: Homeostatic control of adenosine levels and functions in brain
Chapter 3: Glutamate homeostasis as a regulatory of neurotransmitter recycling and synaptic function)
Chapter 4: Homeostasis of neuronal excitability via synaptic and intrinsic inhibitory mechanisms

Part II: Homeostatic Control: Systems, Cells and Organelles
Chapter 5: Role of astrocytes in sleep and epilepsy
Chapter 6: Neuron-astrocyte interactions
Chapter 7: Homeostatic synaptic scaling at central synapses
Chapter 8: Homeostatic role of heterosynaptic plasticity
Chapter 9: The Blood Brain Barrier
Chapter 10: Inflammation and immunomodulation in epilepsy and its comorbidities
Chapter 11: Neuroplasticity
Chapter 12: Epigenetics
Chapter 13: Adult neural stem cells and brain homeostasis

Part III: Homeostatic Manipulators: Preventative and Restorative Opportunities
Chapter 14: Systems (network) pharmacology for brain functionality restoration
Chapter 15: Ketogenic diets, mitochondria, and neurological diseases
Chapter 16: Dietary manipulations
Chapter 17: Exercise
Chapter 18: Sleep
Chapter 19: Botanicals
Chapter 20: The role of acupuncture in nociception homeostasis
Chapter 21: Meditation
Chapter 22: Neurotrophic regulation in neurorestoration of brain

Part IV: Homeostatic Therapies for Disease and Dysfunction
Chapter 23: Epilepsy
Chapter 24: Traumatic Brain Injury
Chapter 25: Adenosine and Alzheimer's Disease, a possible epigenetic link
Chapter 26: Brain homeostasis and Parkinson's Disease
Chapter 27: Brain homeostasis and addiction
Chapter 28: Anxiety and stress disorders
Chapter 29: Malignant brain cancer management with metabolic therapy
Chapter 30: Obesity and diabetes: Nature, nurture, and beyond
Chapter 31: Autism spectrum disorders and homeostasis


Detlev Boison is the Robert Stone Dow Chair of Neurology; the Director of Neurobiology Research; and the Director of Basic and Translational Research at the Legacy Research Institute; Susan A. Masino is the Vernon Roosa Professor of Applied Science; and a Professor of Neuroscience and Psychology at Trinity College