ISBN : 9780198717348
New to this Edition:
Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.
Using the hallmarks of cancer as a starting point, the book looks at the cellular and molecular mechanisms underpinning the transformation of cells into cancer cells. After discussing the theory, each chapter then demonstrates how this knowledge can be directly applied to the development of new targeted therapies, giving the reader a clear appreciation of how the theory translates to tackling the disease.
Drawing on the latest research in this dynamic field, the author makes cutting edge science readily accessible. The book features a variety of learning features - 'Pause and think', 'How do we know that?', self-tests and activities - to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the subject to the point of overwhelming with detail, but on acquiring a solid understanding of the essentials and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit.
2: DNA structure and stability: mutations versus repair
3: Regulation of gene expression
4: Growth factor signaling and oncogenes
5: The cell cycle
6: Growth inhibition and tumor suppressor genes
8: Cancer stem cells and the regulation of self-renewal and differentiation pathways: focus on colon cancer and leukemias
11: Nutrient and hormone effects on the genome
12: Tumour immunology and immunotherapy
13: Infectious agents and inflammation
14: Technology and drug and diagnostics development
Dr Pecorino's monumental achievement highlights the most up-to-date and exciting discoveries ongoing in the molecular studies of cancer. - Professor David Lyden, Weill Cornell Medical College, Cornell University
Review from previous edition Review of previous edition: Pecorino gets the balance right between cell and molecular biology, focusing on mechanism rather than disease. Importantly the students like the text and can afford to buy the book. Therefore it is a real support to our learning program and actually used by the students. - Dr Bernard Mahon, Biology Department/Institute of Immunology, National University of Ireland, Ireland
Review of previous edition: The textbook is clearly written and the author does a great job of introducing some of the more fundamental concepts. The book is organized well and the topics flow smoothly and logically. The book also nicely pulls in current therapeutic approaches with the molecular lesions that are responsible for the generation of cancer. - Professor Deborah Vestal, Department of Biological Sciences, University of Toledo, USA
Review of previous edition: I found this book very helpful in understanding this otherwise very difficult subject. I think this is the only book which has been written for the learners. The writing style, illustrations and the unique features like 'pause and think' are unprecedented and very helpful. Lauren Pecorino must be a very good teacher. - Dr Waqqar Ali, Registrar Radiation Oncology, Cork University Hospital
Review of previous edition: Dr. Pecorino has done a fantastic job... The book's engaging writing-style and well thought out structure welcomes anyone with an interest in studying cancer in thorough, interesting detail. Reading this text was a pleasure, benefited me greatly educationally and made me feel like being a real part of the teaching - as though things were being explained to me in a one-on-one tutorial, an experience that most other medical textbooks don't provide! - Amazon.co.uk reviewer