Neuroimaging Genetics: Principles and Practices

ISBN : 9780199920211

Kristin L. Bigos; Ahmad R. Hariri; Daniel R. Weinberger
432 ページ
216 x 279 mm

The field of neuroimaging genetics has grown exponentially over the past decade. To date there are more than 10,000 published papers involving MRI, PET, MEG and genetics. Neuroimaging Genetics: Principles and Practices is the comprehensive volume edited by Drs. Bigos, Hariri, and Weinberger and co-authored by the preeminent scholars in the field. This text reviews the basic principles of neuroimaging techniques and their application to neuroimaging genetics. The work presented in this volume elaborates on the explosive interest from diverse research areas in psychiatry and neurology in the use of imaging genetics as a unique tool to establish and identify mechanisms of risk, establish biological significance, and extend statistical evidence of genetic associations. Examples throughout highlight the application of imaging genetics to understand neurochemical systems and pathways, explore relationships between genetics and the structural and functional connectivity in human brain, and provide insight into mechanisms of risk for psychiatric and neurologic illness.


1. Neuroimaging genetics
Kristin L. Bigos, Ahmad R. Hariri, Daniel R. Weinberger
Imaging Genetics and Neurochemistry
2.Molecular Neuroimaging Genetics
Patrick M. Fisher, Gitte Moos Knudsen
3. Neuroreceptor Imaging of Genetic Variation Impacting the Serotonin Transporter
Greg Perlman, Christine DeLorenzo, J. John Mann, Ramin Parsey
4. Imaging of Genetic Variation Impacting Dopamine Transmission Parameters
Elsmarieke van de Giessen, Rassil Ghazzaoui, Raj Narendran, Anissa Abi-Dargham
5. Imaging Genetics of Dopamine Synaptic Terminal Activity
Giuseppe Blasi, Alessandro Bertolino
Imaging Genetics and Drug Discovery
6. Variability of Antidepressant Drug Response: Contribution of Imaging Genetics studies
Ulrich Rabl, Bernhard M. Meyer, Lukas Pezawas
7. Imaging Genetics of Pharmacological Response in Psychiatric Disorders
Philip R. Szeszko, Anil K. Malhotra
Imaging Genetics and Genetic Discovery
8. Imaging Genetics of Williams Syndrome
Daniel P. Eisenberg, Ranjani Prabhakaran, Karen F. Berman
9. Identifying Unanticipated Genes and Mechanisms in Serious Mental Illness: GWAS Based Imaging Genetics Strategies
Steven G. Potkin, Theo G. M. van Erp, Shichun Ling, Fabio Macciardi, Xiaohui Xie
10. Imaging Genetics of Brain Structure
Jason L. Stein, Derrek P. Hibar, Paul M. Thompson
11. Imaging Genetics of the Reward System
Caroline F. Zink
Imaging Genetics and Disease
12. Imaging Genetics of Schizophrenia
Thomas M. Lancaster, Joanne L. Doherty, David E. Linden, Jeremy Hall
13. Imaging Genetics of Depression
Matthew D. Sacchet, Lara C. Foland-Ross, Ian H. Gotlib
14. Imaging Genetics of Anxiety Disorders
Mats Fredrikson
15. Imaging Genetics of Bipolar Disorder
Martin Tesli, Ole A. Andreassen
16. Genetic-neuroimaging Studies of Basal Ganglia Disorders
Trevor W. Robbins, James B. Rowe, Roger A. Barker
17. Imaging Genetics of Antisocial Behavior and Psychopathy
Hayley M. Dorfman, Joshua W. Buckholtz
Imaging Genetics and the Environment
18. Incorporating the Environment into Neurogenetics Research: An Imaging Gene by Environment Interactions (IG x E) Approach
Luke W. Hyde, Ryan Bogdan, Ahmad R. Hariri
Imaging Genetics and Cognition
19. Imaging Genetics of Episodic Memory
Bjorn Rasch, Susanne Erk, Andreas Papassotiropoulos, Dominique J.-F. de Quervain
20. Imaging Genetics of Working Memory
Tristram A. Lett, Eva J. Brandl, Daniel J. Muller, Andreas Heinz, Henrik Walter
Imaging Genetics of Advancing Age
21. Neurobiology and Genetics of Cognitive Aging: Insights from Neuroimaging Studies
John C. Muse, Milap A. Nowrangi, Daniel R. Weinberger, Venkata S. Mattay
22. Neuroimaging Genetics of Alzheimer's Disease
Theresa M. Harrison, Alison C. Burggren, Susan Y. Bookheimer
Imaging Genetics and Multi-Locus Models
23. Imaging Genetics of the Hypothalamic Pituitary Adrenal Axis: Implications for Psychopathology
Nadia S. Corral-Frias, Lindsay J. Michalski, Christina R. Di Iorio, Ryan Bogdan


Kristin L. Bigos is an Investigator in the Division of Clinical Pharmacology at the Lieber Institute for Brain Development; Ahmad R. Hariri is a Professor in the Departments of Psychology and Neuroscience at Duke University; Daniel R. Weinberger is Director and CEO of the Lieber Institute for Brain Development at Johns Hopkins Medical Campus