Bipolar Disorder in Youth: Presentation, Treatment and Neurobiology

ISBN : 9780199985357

Stephen M. Strakowski; Melissa P. DelBello; Caleb M. Adler
400 ページ
189 x 257 mm

Bipolar disorders affect up to 3% of the world's population and are the 6th leading cause of disability worldwide. The estimated annual costs of bipolar disorder approach $50 billion in the United States, and the associated societal and personal suffering is immeasurable. Bipolar disorder is a lifelong illness that typically begins in mid-adolescence, thereby disrupting healthy developmental processes. It is also a progressive illness, making early intervention even more critical. As the disorder presents differently in youth as it does in adults, considerable controversy exists around the diagnosis in young people. The neurobiological factors leading to the onset of bipolar disorder reflect abnormalities in adolescent brain development. Bipolar disorder is strongly heritable and therefore, these developmental abnormalities likely represent the culmination of processes that precede the expression of symptoms. Current studies of children who are at risk for bipolar disorder are identifying these processes. Again, controversy exists about how to move these neuroscience gains forward to help affected individuals and, particularly to manage children at risk to delay or prevent the onset or progression of bipolar disorder. With these considerations in mind, Bipolar Disorder in Youth provides a timely, focused review of the diagnosis, treatment, and neurobiology of bipolar disorder in youth. It addresses current controversies and resolves those in which evidence is available. The book is organized into three sections based on these topics to provide comprehensive discussions to aid clinicians managing these individuals in their practices, as well as scientists trying to advance the field. The three editors are widely recognized experts in bipolar disorder, and the authors of each chapter represent international experts in the respective topics. Consequently, this book is the most comprehensive volume available discussing this important population and is a 'must' for the libraries of clinicians and scientists working with bipolar children and adolescents.


Prologue: Introduction to bipolar disorder in youth
Section 1: Phenomenology and Diagnosis
Chapter 1: Progression of Bipolar Disorder in Youth: Defining the early clinical stages in the development of bipolar disorder
Anne Duffy
Chapter 2: Presentation of mania/bipolar I in youth: comparison with adults
Gabrielle A. Carlson
Caroly Pataki
Chapter 3: Differential Diagnosis of Bipolar Disorder in Children and Youth
Kenneth E. Towbin
Ellen Leibenluft
Chapter 4: Comorbid conditions in youth with and at-risk for bipolar disorder
Gagan Joshi
Timothy Wilens
Chapter 5: Heritability of bipolar disorder
Katie Maho
Katherine E. Burdick
Anil K. Malhotra
Chapter 6: Non-heritable risk factors for bipolar disorders
Robert K. McNamara
Jeffrey R. Strawn
Section 2: Treatment of bipolar disorder in youth
Chapter 7: Ethical consideration for treating at-risk populations
Aswin Ratheesh
Michael Berk
Patrick D. McGorry
Chapter 8: Medical treatment strategies for young people with bipolar disorder
Sarah M. Lytle
Sonal K. Moratschek
Robert L. Findling
Chapter 9: Psychotherapeutic strategies for treating youth with or at risk for bipolar disorder
David J. Miklowitz
Chapter 10: Complementary and Alternative Medicine in Child and Adolescent Bipolar Disorder
Barbara L. Gracious
Sathyan Gurumurthy
Alexandra Cottle
Taylor McCabe
Section 3: Neurobiology of bipolar disorder
Chapter 11: Neurobiology of Developing Bipolar Disorder
Jillian M. Russo
Sonja M.C. de Zwarte
Hilary P. Blumberg
Chapter 12: Neurobiology of bipolar disorder in youth
Mani N. Pavaluri
Chapter 13: Neurocognitive Models of Evolving Bipolar Disorder in Youth
Alessandra M. Passarotti
Chapter 14: The neural effects of intervention in pediatric bipolar disorder
Manpreet K. Singh
Kiki D. Chang
Chapter 15: Integration and Future Direction: Toward improving outcomes for youth with bipolar disorder
Luis Rodrigo Patino Duran
Peirce Johnston
Caleb M. Adler
Melissa P. DelBello
Stephen M. Strakowski


Drs. Strakowski, DelBello and Adler comprise one of the most widely recognized research groups studying the neurophysiology, outcome and treatment of bipolar disorder and related conditions. Their work concentrates on early course illness progression and has defined many of the brain system dysfunctions that underlie bipolar disorder as well as treatment interventions in youth.