Chronic Medical Disease and Cognitive Aging: Toward a Healthy Body and Brain

ISBN : 9780199793556

Kristine Yaffe
314 ページ
162 x 241 mm

Chronic Medical Disease and Cognitive Aging: Toward a Healthy Body and Brain explores the important and often overlooked connection between how chronic medical diseases of the body can affect cognitive function and brain health. As population demographics shift to that of an aging population it has become more important to understand and improve cognitive function in late life. Chronic medical diseases often increase the risk of cognitive impairment, and those with cognitive impairment may be less able to effectively manage their medical conditions, suggesting a reciprocal relationship may exist where medical disease impacts cognition that in turn may exacerbate physical health. Chronic Medical Disease and Cognitive Aging discusses current research on the association between a variety of chronic medical diseases and cognition and, where appropriate, promising interventions or accepted treatment strategies. While a cure for many diseases continues to be elusive, insights garnered from the interplay between diseases of the body and mind may help point the way to novel therapeutic strategies to improve cognitive function in late life.


Introduction Kristine Yaffe, MD
Chapter 1 Epidemiological insights into blood pressure and cognitive disorders Lenore J. Launder, PhD
Chapter 2 Cholesterol, Statins, and Late-life cognitive disorders Alina Solomon, MD, PhD and Miia Kivipelto, MD, PhD
Chapter 3 Cardiovascular Disease and Cognitive Aging Angela L. Jefferson, PhD, and Melissa Thompson, DVM
Chapter 4 Obesity and Cognitive Health: Implications of an Altered Adiposity Milieu over the Lifecourse Rachel A. Whitmer, PhD and Deborah R. Gustafson, MS, PhD
Chapter 5 Insulin Resistance and Pathological Brain Aging Brenna Cholerton, PhD, Laura D. Baker, Ph.D., and Suzanne Craft, PhD
Chapter 6 Metabolic Syndrome, other Composite Vascular Risk Scores, and Cognitive Impairment Jose Alejandro Luchsinger, MD, MPH
Chapter 7 Chronic Kidney Disease and Cognitive Aging Manjula Kurella Tamura, MD, MPH
Chapter 8 Sleep Disorders and Cognitive Function in Older Adults Adam P. Spira, PhD, and Sonia Ancoli-Israel, PhD
Chapter 9 Physical Activity and Cognitive Aging Deborah E. Barnes, PhD, MPM, and Nicola T. Lautenschlager MD
Chapter 10 Dietary Patterns and Dementia Pascale Barber-Gateau, MD, PhD, Catherine Feart PhD, and Cecilia Samieri PhD
Chapter 11 Inflammation and Cognitive Decline Roisin Gallinagh Smith, Stephen Todd, MD and Peter A. Passmore, MD
Chapter 12 HIV Infection and Aging: An Emerging Chronic Medical Illness Lauren Wendelken, MA and Victor Valcour, MD
Chapter 13 Postoperative Delirium and Cognitive Decline Jacqueline M. Leung, MD, MPH and Tiffany L. Tsai


Kristine Yaffe, MD, is a Roy and Marie Scola Endowed Chair in Psychiatry and professor of psychiatry, neurology, and epidemiology and biostatistics at the University of California San Francisco and Director of the Memory Disorders clinic at San Francisco Veteran's Administration Medical Center. Dr. Yaffe's research focuses on determining predictors, biological mechanisms, and outcomes of cognitive decline and dementia in older adults, with the goal of identifying modifiable risk factors that may lead to novel strategies to prevent cognitive decline. She has received numerous grants from the NIH, DOD and private foundations and has published over 200 articles in prestigious journals.