The Oxford Handbook of the Auditory Brainstem

ISBN : 9780190849061

Karl Kandler
768 Pages
171 x 248 mm
Pub date
Sep 2019
Oxford Handbooks
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  • Emphasizes plasticity processes and mechanisms in the auditory brainstem
  • Chapters illustrate a wide range of structural and functional plasticity that occurs in the healthy as well as diseased brain.
  • Chapters written by international leaders in the field

The Oxford Handbook of The Auditory Brainstem provides an introduction as well as an in-depth reference to the organization and function of ascending and descending auditory pathways in the mammalian brainstem. Individual chapters are organized along the auditory pathway beginning with the cochlea and ending with the auditory midbrain. Each chapter provides an introduction to the respective area, and summarizes our current knowledge before discussing disputes and challenges the field currently faces. 
A major emphasis throughout this book is on the numerous forms of plasticity that are increasingly observed in many areas of the auditory brainstem. Several chapters focus on neuronal modulation of function and synaptic, neuronal, and circuit plasticity, especially under circumstances when they occur most prominently: during development, aging, and following peripheral hearing loss. In addition, the book addresses the role of trauma-induced maladaptive plasticity with respect to its contribution in generating central hearing dysfunction such as hyperacusis and tinnitus. 
The book is intended for students and postdocs starting in the auditory field, and researchers of related fields who wish to get an authoritative and up-to-date summary of the current state of auditory brainstem research. For clinical practitioners in audiology, otolaryngology, and neurology, the book is a valuable resource of information about the neuronal mechanisms that are major candidates for the generation of central hearing dysfunction.


About the Editor
Introduction and Overview
1. Wiring the Cochlea for Sound Perception
Brikha R. Shrestha and Lisa V. Goodrich
2. The Diversified Form and Function of Cochlear Afferents
Paul Albert Fuchs
3. Efferent Innervation to the Cochlea
Ana Belen Elgoyhen, Carolina Wedemeyer, and Mariano N. Di Guilmi
4. The Cochlear Nuclei: Synaptic Plasticity in Circuits and Synapses in the Ventral Cochlear Nuclei
Donata Oertel, Xiao-Jie Cao, and Alberto Recio-Spinoso
5. In Vitro Studies of Neuromodulation and Plasticity in the Dorsal Cochlear Nucleus
Laurence O. Trussell
6. Molecular and Structural Changes in the Cochlear Nucleus in Response to Hearing Loss
Maria E. Rubio
7. Age-Related and Noise-Induced Hearing Loss: Central Consequences in the Ventral Cochlear Nucleus
Ruili Xie, Tessa-Jonne F. Ropp, Michael R. Kasten, and Paul B. Manis
8. The Cochlear Nucleus as a Generator of Tinnitus-Related Signals
J.A. Kaltenbach and D.A. Godfrey
9. Multimodal Inputs to the Cochlear Nucleus and Their Role in the Generation of Tinnitus
Susan E. Shore and David T. Martel
10. Perinatal Development of the Medial Nucleus of the Trapezoid Body
Shobhana Sivaramakrishnan, Ashley Brandebura, Paul Holcomb, Daniel Heller, Douglas Kolson, Dakota Jackson, Peter H. Mathers, and George A. Spirou
11. Extraction of Auditory Information by Modulation of Neuronal Ion Channels
Leonard K. Kaczmarek
12. The Medial Superior Olivary Nucleus: Meeting the Need for Speed
Benedikt Grothe, Christian Leibold, and Michael Pecka
13. Lateral Superior Olive: Organization, Development, and Plasticity
Eckhard Friauf, Elisa G. Krachan, and Nicolas I.C. Muller
14. The Superior Paraolivary Nucleus
Anna K. Magnusson and Marcelo Gomez-Alvarez
15. Perineuronal Nets in the Superior Olivary Complex: Development, Function and Plasticity
Markus Morawski and Mandy Sonntag
16. The Nuclei of the Lateral Lemniscus
Felix Felmy
17. Axon Trajectories in the Auditory Brainstem
Nell Beatty Cant
18. Neuron Types, Intrinsic Circuits, and Plasticity in the Inferior Colliculus
Tetsufumi Ito, Munenori Ono, and Douglas L. Oliver
19. Changes in the Inferior Colliculus Associated with Hearing Loss: Noise-Induced Hearing Loss, Age-Related Hearing Loss, Tinnitus and Hyperacusis
Alan R. Palmer and Joel I. Berger
20. Unifying the Midbrain: The Commissure of the Inferior Colliculus
Adrian Rees and Llwyd D. Orton
21. Neuromodulatory Feedback to the Inferior Colliculus
Laura Hurley
22. Descending Auditory Pathways and Plasticity
Brett R. Schofield and Nichole L. Beebe
23. Aging Processes in the Subcortical Auditory System
Donald M. Caspary and Daniel A. Llano
24. Glial Cells in the Auditory Brainstem
Giedre Milinkeviciute and Karina S. Cramer
25. Deviance Detection and Encoding Acoustic Regularity in the Auditory Midbrain
Manuel S. Malmierca, Guillermo V. Carbajal, and Carles Escera
26. Brainstem Encoding of Speech and Music Sounds in Humans
Nina Kraus and Trent Nicol
27. The Auditory Brainstem Implant: Restoration of Speech Understanding from Electric Stimulation of the Human Cochlear Nucleus
Robert V. Shannon

About the author: 

Edited by Karl Kandler, PhD, Professor of Neurobiology, Otolaryngology, and Bioengineering, University of Pittsburgh School of Medicine
Karl Kandler is Professor of Neurobiology, Otolaryngology, and Bioengineering at the University of Pittsburgh, Pennsylvania, USA. He was born in Germany where he studied Biology at the University of Regensburg and the Eberhard Karls University of Tubingen, from which he graduated 1993 with a PhD. From 1993 to 1997, he performed postdoctoral research with Lawrence C. Katz at Howard Hughes Medical Institute and Duke University. Since 1998, Dr. Kandler is a faculty in the School of Medicine at the University of Pittsburgh investigating the development and plasticity of auditory circuits in the mammalian brain. From 2007 to 2017, he established and directed the auditory research group in the department of otolaryngology at this institution. In addition, Karl Kandler is a faculty member of the Center for the Neural Basis of Cognition and an adjunct Professor in the Department of Biological Sciences, Carnegie Mellon University.
Nichole L. Beebe, Northeast Ohio Medical University, USA
Joel I. Berger, University of Nottingham, UK
Ashley Brandebura, West Virginia University, USA
Nell Beatty Cant, Duke University Medical Center, USA
Xiao-Jie Cao, University of Wisconsin-Madison, USA
Guillermo V. Carbajal, University of Salamanca & Salamanca Institute for Biomedical Research, Spain
Donald M. Caspary, Southern Illinois University, USA
Karina S. Cramer, University of California, Irvine, USA
Mariano N. Di Guilmi, National Council of Scientific and Technical Research, Argentina
Ana Belen Elgoyhen, National Council of Scientific and Technical Research & University of Buenos Aires, Argentina
Carles Escera, University of Barcelona, Spain
Felix Felmy, University of Veterinary Medicine Hannover, Germany
Eckhard Friauf, University of Kaiserslautern, Germany
Paul Albert Fuchs, Johns Hopkins University, USA 
D.A. Godfrey, University of Toledo, USA
Marcelo Gomez-Alvarez, Karolinska Institute, Sweden
Lisa V. Goodrich, Harvard Medical School, USA
Benedikt Grothe, Ludwig Maximilian University of Munich, Germany
Daniel Heller, West Virginia University, USA
Paul Holcomb, West Virginia University, USA
Laura Hurley, Indiana University, USA
Tetsufumi Ito, Kanazawa Medical University, Japan
Dakota Jackson, West Virginia University, USA
Leonard K. Kaczmarek, Yale University, USA
J.A. Kaltenbach, Cleveland Clinic, USA
Michael R. Kasten, University of North Carolina, USA
Douglas Kolson, West Virginia University, USA
Elisa G. Krachan, University of Kaiserslautern, Germany
Nina Kraus, Northwestern University, USA
Christian Leibold, Ludwig Maximilian University of Munich, Germany
Daniel A. Llano, University of Illinois at Urbana-Champaign, USA
Anna K. Magnusson, Karolinska Institute, Sweden
Manuel S. Malmierca, University of Salamanca, Spain
Paul B. Manis, University of North Carolina, USA
David T. Martel, University of Michigan, USA
Peter H. Mathers, West Virginia University, USA
Giedre Milinkeviciute, University of California, Irvine, USA
Markus Morawski, University of Leipzig, Germany
Nicolas I.C. Muller, University of Kaiserslautern, Germany
Trent Nicol, Northwestern University, USA 
Donata Oertel, University of Wisconsin-Madison, USA
Douglas L. Oliver, University of Connecticut, USA
Munenori Ono, Kanazawa Medical University, Japan
Llwyd D. Orton, Manchester Metropolitan University, UK
Alan R. Palmer, University of Nottingham, UK
Michael Pecka, Ludwig Maximilian University of Munich, Germany
Alberto Recio-Spinoso, University of Castilla-La Mancha, Spain
Adrian Rees, Newcastle University, UK
Tessa-Jonne F. Ropp, University of North Carolina, USA
Maria E. Rubio, University of Pittsburgh, USA
Brett R. Schofield, Northeast Ohio Medical University, USA
Robert V. Shannon, University of Southern California, USA
Susan E. Shore, University of Michigan, USA
Brikha R. Shrestha, Harvard Medical School, USA
Shobhana Sivaramakrishnan, West Virginia University, USA
Mandy Sonntag, University of Leipzig, Germany
George A. Spirou, West Virginia University, USA
Laurence O. Trussell, Oregon Health and Science University, USA
Carolina Wedemeyer, National Council of Scientific and Technical Research, Argentina
Ruili Xie, University of Toledo, USA

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