Polymorphism in Molecular Crystals 2e (2nd edition)

ISBN : 9780199655441

Joel Bernstein
704 Pages
156 x 234 mm
Pub date
May 2020
International Union of Crystallography Monographs on Crystallography
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  • Introduces the basics and principles of polymorphism
  • Provides experimental methods and theoretical guidelines for searching for and identifying polymorphs
  • Summarizes the latest methods for analysing and characterizing polymorphs
  • Three separate chapters discuss in detail the importance of polymorphism in pharmaceuticals, pigments and energetic materials
  • Special chapter on polymorphism and patents deals with issues and examples of litigations on pharmaceuticals involving polymorphism

New to this Edition:

  • Major revision of methods of searching for polymorphs, both computationally and experimentally
  • Major update of experimental and analytical methods for identifying and characterizing polymorphs
  • Updates of major developments related to polymorphism in pharmaceuticals, high energy materials and pigments, including extensive references
  • Complete revision of the chapter on polymorphism and patents with descriptions of a number of important litigations since the first edition
  • Over 1000 new references, covering new literature since the previous edition

Most people are familiar with the fact that diamond and graphite are both composed only of carbon; yet they have very different properties which result from the very different structures of the two solids - they are polymorphs of carbon. Understanding the relationship between the structures and the properties of materials is of fundamental importance in developing and producing new materials with improved or new properties. The existence of polymorphic systems allows the direct study of the connection between structures and properties. This book provides grounding on the fundamental structural and energetic basis for polymorphism, the preparation and characterization of polymorphic substances and its importance in the specific areas of pharmaceuticals, pigments and high energy (explosive) materials. The closing chapter describes the intellectual property implications and some of the precedent patent litigations in which polymorphism has played a central role. The book contains over 2500 references to provide a ready entry into the relevant literature.


1: Introduction and historical background
2: Fundamentals
3: Exploring the crystal form landscape
4: Analytical techniques for studying and characterizing polymorphs and polymorphic transitions
5: Computational aspects of polymorphism
6: Polymorphism and structure-property relations
7: Polymorphism of pharmaceuticals
8: Polymorphism of pigments and dyes
9: Polymorphism of high energy materials
10: Polymorphism and patents

About the author: 

Joel Bernstein, Professor Chemistry, Emeritus, Ben-Gurion University of the Negev
Joel Bernstein earned his Ph.D. in physical chemistry at Yale University for research on solid-state spectroscopy of organic compounds. Following postdoctoral stints at UCLA and the Weizmann Institute of Science, he joined the faculty of the newly established Ben-Gurion University of the Negev, where until 2010 he was the Carol and Barry Kaye Professor of Applied Science in the Chemistry Department. From 2010-2016, he was Global Distinguished Professor of Chemistry at New York University, both in Abu Dhabi and Shanghai. His research interests center on the organic solid state, with emphasis on understanding and utilizing polymorphism, structure-property relationships, hydrogen-bonding patterns and graph sets and organic conducting materials. He has published nearly 200 research and review articles and chapters on these subjects. He has served as a consultant to many multinational pharmaceutical companies and as a testifying witness in patent litigations on the solid-state chemistry of drugs.

"Review from previous edition Joel Bernstein's book represents the single most important source for the development of critical understanding of polymorphism and its commercial and industrial importance and might well play a decisive role in categorizing and reorganizing problems and endeavours on polymorphism-related research. " - Current Engineering Practice

"... clear, vigorous, well-written and very readable ... There seems to be nothing relevant that Bernstein has not included; his scholarship and command and study of the vast literature are remarkable ... an excellent work." - Current Engineering Practice

"... an excellent resource book and a very good read ... can be recommended strongly both for content and interest. " - Crystallographic Newsletter

"... a delight to review this eagerly awaited tome ... In the end, the proof of the pudding is in the eating, and in my opinion, Bernstein has served us a nutritional feast here. Enjoy! " - Cryst. Growth Des.

"It will be the book, for a long time to come, to which students and researchers will turn with confidence, as well as pleasure, in all questions of polymorphism in molecular crystals. " - Structural Chemistry

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