OXFORD UNIVERSITY PRESS

Paraneoplastic Syndromes

ISBN : 9780199772735

Price(incl.tax): 
¥30,030
Author: 
Robert B. Darnell; Jerome B. Posner
Pages
496 Pages
Format
Hardcover
Size
189 x 260 mm
Pub date
Sep 2011
Series
Contemporary Neurology Series
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Paraneoplastic syndromes, defined in this book as "disorders caused by cancer, but not a direct result of cancer invasion of the affected organ or tissue", once believed to be rare and esoteric neurologic disorders have assumed increasing importance as an explanation of neurologic and other symptoms in patients suffered from occult or controllable cancers. This book attempts a comprehensive review of paraneoplastic syndromes from considering both clinical and pathophysiologic aspects. The book is divided into 4 sections: The first is an overview, classifying the disorders, describing a clinical approach to the diagnosis and treatment of paraneoplastic syndromes in general and identifying their pathogenesis. The second section discusses the clinical findings and treatment of individual paraneoplastic syndromes with chapters dedicated to each of the neurologic syndromes and a chapter discussing nonneurologic syndromes such as endocrine, cutaneous, and rheumatologic paraneoplastic disorders. The third section discusses autoantibodies that characterize individual paraneoplastic syndromes. The final section discusses the paraneoplastic syndromes associated with individual cancers.

Index: 

Contents
SECTION 1 OVERVIEW
1. HISTORY
DEFINITIONS
CLASSIFICATION
HISTORY
Pathogenesis
EPIDEMIOLOGY
IMPORTANCE
2. CLINICAL FINDINGS, TREATMENT AND PROGNOSIS
INTRODUCTION
CLINICAL APPROACH
The Patient without Known Cancer The Patient with Known Cancer
CLUES TO DIAGNOSIS
Clinical Findings Laboratory Investigation
PATHOLOGY
TREATMENT
Plasma Exchange (Plasmapheresis) Intravenous Immunoglobulin
Rituximab Cyclophosphamide Corticosteroids Human Chorionic Gonadotropin Recommendations
PROGNOSIS
3. PATHOGENESIS
INTRODUCTION
HISTORICAL VIEWS
Toxic Substances Competition for Essential Substrate Bullet Opportunistic Infection Immune Mediated
CURRENT CONCEPTS OF PATHOGENESIS
Unresolved Questions Conclusions
ANIMAL MODELS
SECTION 2 CLINICAL SYNDROMES
4. BRAIN (CEREBRUM)
INTRODUCTION
CEREBRAL CORTEX
WHITE MATTER DEMYELINATION
BLOOD VESSELS (VASCULITIS)
HIPPOCAMPUS/LYMBIC ENCEPHALITIS
TASTE

About the author: 

Dr. Darnell studied neurology as Chief Resident with Dr. Fred Plum at The New York Hospital, Cornell, and then, beginning in 1990 and continuing through the present time, with Dr. Jerome Posner at Memorial Sloan-Kettering Cancer Center. Dr. Darnell is currently the Heilbrunn Cancer Professor and Senior Physician at The Rockefeller University and an Investigator with the Howard Hughes Medical Institute, and is an Affiliate Attending Neurologist at Memorial Sloan-Kettering Cancer Center. ; Dr. Posner did a Neurology residency at the University of Washington under Dr. Fred Plum. C. Cotzias of Neuro-Oncology at Memorial Sloan-Kettering cancer Center and was recently in only clinical research professor ship from the American Cancer Society.

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