ISBN : 9780199685707

David Nutt; Liam Nestor
104 Pages
129 x 197 mm
Pub date
Sep 2013
Oxford Psychiatry Library
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Part of the Oxford Psychiatry Library series, this pocketbook is a clear and comprehensive overview of the brain science underpinning addiction and how this helps explain the current and future therapeutics for the range of addictions, using full colour images to enhance understanding. Addiction focuses on the nature of addiction as a brain disorder that includes a range of different behavioural traits such as impulsivity and reward dependence, and discusses the critical role of kinetic and pharmacological factors. The text explains how the primary pharmacological targets of drugs of abuse are now understood, the relation to the variable nature of addiction to different substances, and how this may lead to new approaches to treatment.


1. What is addiction?
2. Burden of addiction
3. Key elements of addiction
4. Neurobiological processes in addiction
5. Drug pharmacokinetics and abuse liability
6. Pharmocodynamics of addictive substances
7. The dopamine system and addiction
8. The GABA System and Addiction
9. The Glutamate System and Addiction
10. The Opioid System and Addiction
11. Conclulsion and overview

About the author: 

David Nutt, Neuropsychopharmacology Unit Department of Medicine Imperial College London London, UK; Liam Nestor, Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London

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