Angelo Mosso's Circulation of Blood in the Human Brain

ISBN : 9780199358984

Marcus E. Raichle; Gordon M. Shepherd. DPhil.
240 Pages
162 x 236 mm
Pub date
Nov 2014
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Modern brain imaging is revolutionizing the study of brain function in health and disease. Few realize that its origins began with a pioneering study in the nineteenth century by an Italian scientist, Angelo Mosso, of several subjects brought to him with head injuries that exposed their brains to direct observation. He took advantage of this opportunity to observe for the first time changes in cerebral blood flow in relation to different behaviors, the same changes that are the basis for the measurements underlying modern methods. Although Mosso was widely recognized for this highly original study by his contemporaries, through a German translation in 1881, there has never been a translation through which his magnificent achievement could be recognized in English. His rightful role as the pioneer in brain imaging has thus not been recognized. This unique volume corrects that deficiency. Through it, the modern reader, whether an expert in the field or an interested scientist or member of the public, can gain a new perspective on the remarkable insights Mosso gained into how behaviors as subtle as thinking about a subject or feeling an emotion can produce the changes in pulsations of the brain that he observed. The special features of this volume begin with a brief summary of Mosso's life. Two pioneers of modern brain imaging, Marcus Raichle and Gordon M. Shepherd, then provide an extensive commentary that succinctly summarizes Mosso's work and explains its relevance to modern methods. The authors not only emphasize Mosso's role as a pioneer in brain imaging, but also through this study as a pioneer in the eventual rise of cognitive neuroscience. The English translation then follows, together with all of the plates and illustrations of the original volume. The result is a classic of neuroscience now available for wide appreciation by neuroscientists, neurologists, psychologists, psychiatrists, historians of science and medicine, and the general public.


Brief Biography of Angelo Mosso and His Times
Commentary: From Mosso to Modern Brain Imaging
Note on the Translation
Critical Historical Introduction
Translation: The Circulation of the Blood in the Human Brain
1. Notes concerning the disease states of the three subjects in whom
the conditions of the cerebral circulation were studied
2. Description of the apparatus used to record the pulse
of the brain and of other parts of the body
3General information concerning the form of the pulse
4.Concerning the response of the cerebral circulation during enhanced mental
activity and during emotional and sensory impressions
Sleep and its relationship to the cerebral circulation
1. Observations on Catherina X
2. Observations on Thron during sleep
3. Observations on Caudana during sleep
4. Observations on Bertino during sleep
5. Chloral hydrate induced sleep
6. Considerations about the nature of sleep and its
concomitant manifestations
7. Concerning the variations of the cerebral tracings, which depended
on the motions of the vessels and of the heart
8. Concerning the movements of the blood vessels in the external ear
of the rabbit L
9. The influence of breathing on the circulation of the blood in the
brain and in the lungs
10. Experimental critique of the investigations on the pulmonary
circulation undertaken
11. The influence of breathing on the systemic (general) circulation
12. The influence of amyl nitrite on the blood circulation in the brain
13. . Anemia and hyperemia of the brain
14. Concerning the circulation of the blood within the intact skull
15. Investigations concerning the movements of the cerebrospinal fluid.

About the author: 

Marcus E Raichle, MD, PhD, Departments of Radiology, Neurology, Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri, USA; Gordon M Shepherd, PhD, Department of Neurobiology, Yale University Medical School, New Haven, CT, USA.

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