50 Studies Every Doctor Should Know: The Key Studies That Form the Foundation of Evidence Based Medicine (Revised edition)

ISBN : 9780199343560

Michael E. Hochman
352 Pages
156 x 235 mm
Pub date
Dec 2013
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50 Studies Every Doctor Should Know presents key studies that have shaped the practice of medicine. Selected using a rigorous methodology, the studies cover topics ranging from dieting to cardiovascular disease, insomnia to obstetrics. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. Brief information on other relevant studies is provided, and an illustrative clinical case concludes each review. A section of review questions and answers is included at the back of the book to ensure that readers take away the key messages from each study. This book is a must-read for health care professionals and anyone who wants to learn more about the data behind clinical practice.


Section 1: Preventive Medicine
1. Preventing Diabetes: The Diabetes Prevention Program
2. A Comparison of Different Dieting Strategies
3. Aspirin for the Primary Prevention of Cardiovascular Disease: The Physicians' Health Study and the Women's Health Study
4. Postmenopausal Hormone Therapy: The Women's Health Initiative
5. The European Randomized Study of Screening for Prostate Cancer (ERSPC)
6. The Cochrane Review of Screening Mammography
7. The Human Papillomavirus Vaccine: The Future II Trial
Section 2: Internal Medicine
8. Arrhythmia Suppression Following Myocardial Infarction: The CAST Trial
9. Choosing First-Line Therapy for Hypertension: The ALLHAT Trial
10. Statins in Healthy Patients with an Elevated C-Reactive Protein: The JUPITER Trial
11. Rate vs. Rhythm Control for Atrial Fibrillation: The AFFIRM Trial
12. Lenient vs. Strict Heart Rate Control for Atrial Fibrillation: The RACE II Trial
13. Beta-Blockers for Systolic Heart Failure: The MERIT-HF Trial
14. Initial Treatment of Stable Coronary Artery Disease: The COURAGE Trial
15. Treating Elevated Blood Sugar Levels in Patients with Type 2 Diabetes: The United Kingdom Prospective Diabetes Study (UKPDS)
16. Intensive vs. Conservative Blood Sugar Control for Patients with Type 2 Diabetes: The ACCORD Trial
17. The African American Heart Failure Trial (A-HeFT)
18. Early vs. Delayed Antiretroviral Therapy for Patients with HIV: The NA-ACCORD Study
19. Early vs. Late Initiation of Dialysis: The IDEAL Trial
20. Early Goal-Directed Therapy in Sepsis
21. Red Cell Transfusion in Critically Ill Patients: The TRICC Trial
22. Pulmonary Artery Catheters in Critically Ill Patients
23. Step-Up vs. Step-Down Therapy for Dyspepsia: The DIAMOND Trial
24. Opioids for Chronic Non-Cancer Pain
Section 3: Surgery
25. Perioperative Beta-Blockers in Non-Cardiac Surgery: The POISE Trial
26. Cardiac Stents vs. Coronary Artery Bypass Surgery for Severe Coronary Artery Disease: The SYNTAX Trial
27. Carotid Endarterectomy for Asymptomatic Carotid Stenosis: The ACST Trial
28. A Trial of Arthroscopic Knee Surgery
29. Surgery vs. Rehabilitation for Chronic Low Back Pain: The MRC Spine Stabilization Trial
30. Mastectomy vs. Lumpectomy for Invasive Breast Cancer: The B-06 Trial
31. Long Term Impact of Bariatric Surgery: The Swedish Obese Subjects Study
Section 4: Obstetrics
32. The Canadian Multicenter Post-term Pregnancy Trial (CMPPT)
33. Antepartum Glucocorticoids in Premature Labor
Section 5: Pediatrics
34. Treatment of Acute Otitis Media in Children
35. A Trial of Early Ear Tube Placement in Children
36. Inhaled Corticosteroids for Mild Persistent Asthma: The START Trial
37. The Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder (MTA)
38. Measles, Mumps, and Rubella Vaccination and Autism
Section 6: Radiology
39. Magnetic Resonance Imaging for Low Back Pain
40. Screening for Coronary Artery Disease in Asymptomatic Patients with
Diabetes: The DIAD Study
41. Diagnosing Acute Pulmonary Embolism: The Christopher Study
42. Identifying Children with Low-Risk Head Injuries Who Do Not Require
Computed Tomography
Section 7: Neurology and Psychiatry
43. Thrombolysis 3 to 4.5 Hours After an Acute Ischemic Stroke: The ECASS III
44. Initial Treatment of Depression
45. Behavioral vs. Pharmacological Treatment for Insomnia in the Elderly
Section 8: Systems Based Practice
46. The Group Health Medical Home Demonstration
47. A Program to Improve Care Coordination at Hospital Discharge: Project RED
48. Reducing Catheter-Related Blood Stream Infections in the Intensive Care Unit: The Keystone ICU Project
49. Early Palliative Care in Non-Small-Cell Lung Cancer
50. Directly Observed Therapy for the Treatment of Tuberculosis in Baltimore
Section 9: Study Questions and Answers

About the author: 

Medical Director for Innovation, AltaMed Health Services and Robert Wood Johnson Foundation Clinical Scholar, Department of Internal Medicine, University of California, Los Angeles.

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