Primer on Multiple Sclerosis

ISBN : 9780199341016

Barbara S. Giesser
560 Pages
178 x 254 mm
Pub date
Feb 2016
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Primer on Multiple Sclerosis, 2nd Edition is an updated reference manual for the practicing clinician. It covers the range of information needed to treat persons with MS, beginning with basic science and immunopathology, thorough differential diagnosis, symptom management and disease modifying therapies. This essential book also includes material covering new and experimental strategies as well as a review of commonly used complementary and alternative modalities that are used by persons with MS.Multiple Sclerosis (MS) is the most common demyelinating disease of the CNS and the third most common cause of disability among young adults. The complex management issues that are often present in the care of individuals with MS may demand the participation of health care professionals from a variety of disciplines, although the team is usually led by a neurologist. It is therefore essential for the neurologist to have a thorough grounding in the basic science and clinical phenomenology of MS. In this second edition of Primer on Multiple Sclerosis, the latest updates on therapeutics are provided, including new medications that have been FDA- approved since the first edition. Includes new diagnostic criteria, as well as any advances made in current diagnostic techniques, e.g. new imaging metrics. Important new information in the basic sciences and pathophysiology of MS is provided as well as newer epidemiologic studies. Treatment algorithms for common symptoms will be expanded, as well as any new guidelines for switching medications for Disease Modifying treatment "failures". The chapter on alternative and complimentary therapies discusses new research on CCSVI. The chapter on legal issues includes information on the putative effect of the Affordable Health Care Act on access to neurologic care and treatments. Finally, there is expanded discussion of progressive forms of MS both from a basic science and treatment perspective.


Part 1: Historical Background
Chapter 1: The History of Multiple Sclerosis: From the Age of Description to the Age of Therapy
T. Jock Murray

Part 2: Basic Science
Chapter 2: Genetics and Epidemiology in Multiple Sclerosis
Gabriele C. DeLuca, Richard L. Yates and A. Dessa Sadovnick
Chapter 3: Neurophysiology of Multiple Sclerosis
Jefferson C. Slimp
Chapter 4: Immunology of Multiple Sclerosis
Laura Piccio and Anne H. Cross
Chapter 5: Taking a Microscopic Look at Multiple Sclerosis
Yong Guo and Claudia F. Lucchinetti

Part 3: Diagnosis and Prognosis
Chapter 6: Diagnosis of Multiple Sclerosis
Loren A. Rolak
Chapter 7: Neuroimaging in Multiple Sclerosis
Megan Esch & Nancy L. Sicotte
Chapter 8: Cerebrospinal Fluid Profile Supporting a Clinical Definite Multiple Sclerosis Diagnosis
Mark Freedman and Mohammed Abdoli
Chapter 9: Evoked Potentials
Marc R. Nuwer
Chapter 10: Temporal and Clinical Course of Multiple Sclerosis
Erica Grazioli, Cornelia Mihai, and Bianca Weinstock-Guttman
Chapter 11: Outcome Measures in Multiple Sclerosis
Robert M. Herndon

Part 4: Clinical Manifestations
Chapter 12: Neuro-Ophthalmologic Manifestations of Multiple Sclerosis
Shin C. Beh, Elliot M. Frohman, and Teresa Frohman
Chapter 13: Cerebellar and Brainstem Dysfunction in Multiple Sclerosis
Angeli S. Mayadev and George H. Kraft
Chapter 14: Disorders of Mobility in Multiple Sclerosis
Scott Campea and Jodie K. Haselkorn
Chapter 15: Management of Urinary and Bowel Dysfunction in Patients with Multiple Sclerosis
Ja-Hong Kim and Judy M. Choi
Chapter 16: Assessment and Treatment of Sexual Dysfunction in Multiple Sclerosis
Frederick W. Foley
Chapter 17: Gender and Reproductive Issues in Multiple Sclerosis
Rhonda Voskuhl and Barbara S. Giesser
Chapter 18: Cognitive Impairment and Mood Disturbances
Nicholas G. LaRocca
Chapter 19: Multiple Sclerosis and Pain
Norman S. Namerow
Chapter 20: Fatigue in Multiple Sclerosis
Vikram Bhise, Leigh Charvet, and Lauren Krupp
Chapter 21: Sleep Disorders in Multiple Sclerosis
Tiffany J. Braley and Alon Y. Avidan
Chapter 22: Pediatric Multiple Sclerosis
J.M. Tillema, J. Graves, L.A. Benson, G.S. Aaen, A. Belman, J. Parrish, B. Weinstock-Guttman, L. Krupp, T. Chitnis, and E. Waubant

Part 5: Therapeutics
Chapter 23: Neuromyelitis Optica Spectrum Disorders
Dean M. Wingerchuk
Chapter 24: Multiple Sclerosis Nursing
Kirstin Nygren and Gail Hartley
Chapter 25: Immunomodulatory Agents for Relapsing-Remitting Multiple Sclerosis
Jessica F. Robb and Lawrence M. Samkoff
Chapter 26: Immunosuppressive and Novel Therapies
Barbara S. Giesser
Chapter 27: Complementary and Alternative Medicine in Multiple Sclerosis
Allen C. Bowling

Part 6: Psychosocial Issues
Chapter 28: Living with Multiple Sclerosis: The Psychosocial Challenges for Patients and Their Families Rosalind C. Kalb
Chapter 29: Employment and Career Development Considerations
Steven W. Nissen and Phillip D. Rumrill, Jr.
Chapter 30: Legal Planning Issues
Laura D. Cooper, Esq.

Part 7: Research
Chapter 31: Issues in the Design and Interpretation of Multiple Sclerosis Clinical Trials
Stephen Krieger, Ilana Katz Sand, Svenja Oynhausen, and Aaron Miller
Chapter 32: Basic Science in Multiple Sclerosis: Progress and Promise
Wendy Gilmore and Leslie P. Weiner

About the author: 

Barbara S. Giesser, MD is Clinical Director at UCLA MS Clinical Service, David Geffen School of Medicine, Los Angles, CA.

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