ISBN : 9780190929565

Madhukar H. Trivedi; Steven M. Strakowski
520 Pages
178 x 254 mm
Pub date
Dec 2019
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Major depressive disorder (MDD) is a serious, debilitating, life-shortening illness that affects many persons of all ages and backgrounds. The lifetime risk for MDD is 7-12% for men and 20-25% for women (Kessler et al., 2003). MDD is a disabling disorder that costs the U.S. over $200 billion per year in direct and indirect costs (Greenberg et al., 2015), and is the leading cause of disability worldwide (WHO, 2018). Depression also has detrimental effects on all aspects of social functioning (e.g., self-care, social role, and family life, including household, marital, kinship, and parental roles). While there have been several treatments that are efficacious, many individuals suffering from depression experience life-long challenges due to the chronic and episodic nature of the disease. Identifying strategies to find the right treatments for the right patients is critical. Ongoing research has explored the importance of examining physiologic biomarkers, as well as clinical characteristics to gain a better understanding of subtypes of depression, which will lead to improved treatments and better outcomes.
This book provides an introduction to the etiology and pathophysiology of depression, common comorbidities and differential diagnoses, pharmacotherapy strategies, psychotherapeutic and neuromodulation interventions, novel and non-traditional treatment strategies, and considerations in special populations.


1.Introduction and Overview

I. Etiology/Pathophysiology

2. Neurobiology

3. Genetic Risk Factors

4. Environmental and Social Risk Factors

5. Blood-based Biomarkers

II. Comorbidities and Differential Diagnoses

6. Anxiety Disorders

7. Bipolar Disorder

8. Suicidality

9. General Medical Conditions

10. General Medical Conditions, Metabolic Disorders

III. Pharmacotherapy for Depression

11. First line and combination therapeutics

12. Augmentation strategies

13. Rapid-acting antidepressants

14. Side Effects of Antidepressant

15. Strategies for targeting residual symptoms

IV. Psychotherapy and modalities of delivery for Depression

16. Cognitive Behavioral Therapy/Behavioral Activation

17. Behavioral Activation for Depression

18. Psychodynamic and Supportive Psychotherapy


V. Novel, Non-Traditional Treatment Strategies for Depression

20. Exercise as a treatment for depression

21. Therapeutic Mindfulness For Relapse Prophylaxis in Unipolar Depression

22. Probiotics and Neutraceuticals

23. Chronobiological Treatments: Sleep and Light Therapies

VI. Special Populations in Depression

24. Children and Adolescents

25. Elderly Patients

26. Pregnant and Postpartum

27. Depression Following Mild Traumatic Brain Injury

28. Treatment in Primary Care


29. Future Directions: Precision Medicine and Biosignatures

About the author: 

Madhukar Trivedi is Professor of Psychiatry, Chief of the Division of Mood Disorders, and Founding Director of the Center for Depression Research and Clinical Care at UT Southwestern Medical Center. He is an internationally recognized translational researcher focusing on developing and validating biosignatures of depression. He specializes in treating depression and conducts research on pharmacological, psychosocial, and nonpharmacological treatments for depression, including ketamine, magnetic stimulation, and exercise. Holding the Betty Ho Hay Distinguished Chair in Mental Health and the Julie K. Hersh Chair for Depression Research and Clinical Care at UTSW, Dr. Trivedi has received numerous accolades, including the Psychiatric Excellence Award from the Texas Society of Psychiatric Physicians and the Gerald Klerman Senior Investigator Award from the Depression and Bipolar Support Alliance. With over 500 articles and chapters related to the diagnosis and treatment of mood disorders, Dr.; Trivedi was listed on Thomas Reuters' World's Most Influential Scientific Minds in each year since 2014 as one of the most highly cited researchers in the U.S. field of Psychiatry. Series editor: Steven M. Strakowski, MD, Founding Chair, Department of Psychiatry, Dell Medical School, University of Texas, Austin

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