Cognitive Dimensions of Major Depressive Disorder

ISBN : 9780198810940

Bernhard T. Baune; Catherine Harmer
304 Pages
156 x 234 mm
Pub date
Aug 2019
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Major depressive disorder (MDD) is one of the most prevalent mental disorders worldwide, and is estimated to affect 300 million people. Most research defines MDD as a categorical disorder and investigations on clinical, functional, and biological correlates are assessed by established diagnostic instruments. However, given the phenotypic and biological heterogeneity of depression, a re-focus on the clinical phenotype of MDD is required. Bridging psychiatric and psychological traditions Cognitive Dimensions of Major Depressive Disorder, discusses the characteristics of the dimensional approach of MDD. Focusing on the cognitive and emotional processes of depression, this guide offers extended and novel diagnostic and treatment approaches ranging from pharmacological to psychological interventions targeting dimensions of depression. Edited by pioneers in this field, this resource discusses hot topics such as how to define the dimensional approach to depression, the neurobiological underpinnings of cognitive dysfunction in depression, and the impairment of emotional processing deficits in depression. Cognitive Dimensions of Major Depressive Disorder is suitable for students, trainees, clinicians and scientists in the fields of psychology, neuropsychology, psychiatry, cognitive neuroscience, neurology, general practice and also for various other health care professionals.


Section I Major depressive disorder as a multi-dimensional disorder
1 Tracy L. Greer and Jeethu K. Joseph: Functional and psychosocial consequences of major depressive disorder
2 Koen Demyttenaere: Opportunities and challenges of the phenotypic heterogeneity of major depressive disorder
3 Muzaffer Kaser and Barbara J. Sahakian: Major depressive disorder as a disorder of cognition
Section II Cognitive Dysfunction in Depression
4 Zihang Pan and Roger S. McIntyre: Cognitive Dysfunction as a symptom dimension across major psychiatric disorders
5 Maria Serra-Blasco and Raymond W. Lam: Clinical and functional characteristics of cognitive dysfunction in major depressive disorder
6 John E. Harrison: The assessment of cognitive dysfunction in major depressive disorder
7 Natalie T. Mills and Bernhard T. Baune: Molecular neurobiology of cognitive dysfunction in MDD
Section III Impaired emotional processing in MDD
8 Thomas Beblo and Lorenz Dehn: Clinical characteristics of emotional-cognitive dysfunction in MDD
9 Anjali Sankar and Cynthia H.Y. Fu: Neurocircuitries of emotion processing affected in Major Depressive Disorder
10 Oliver J. Robinson: The neural circuitry of negative bias, oversensitivity to negative feedback and hyposensitivity to reward in MDD
11 Georgia O'Callaghan and Argyris Stringaris: Reward processing in adolescents with depression
12 Genevieve Rayner: Cognition-related brain networks underpin cognitive, emotional and somatic symptom dimensions of depression
13 John D. Medaglia: Networks of cognitive processes: Functional and anatomical correlates of cognition, emotions and social cognition
14 Thalia Richter, Alexander J. Shackman, Tatjana Aue, and Hadas Okon-Singer: The neurobiology of emotion-cognition interactions
Section IV Social cognitive processes in Depression
15 Katharina Foerster, Silke Joergens, and Bernhard T. Baune: Clinical characteristics of social cognitive processes in Major Depressive Disorder
16 Franziska K. Goer and Rebecca Elliott: Understanding of self and others: neurobiological underpinnings of social cognition
17 Philippe Fossati, Sophie Hinfray, Anna Fall, Cedric Lemogne, and Jean-Yves Rotge: Emotional and cognitive consequences of social rejection: An entry door to major depression
Section V Interventions and Management
18 Marco Solmi, Beatrice Bortolato, Brendon Stubbs, Nathan Herrmann, and Andre F. Carvalho: Pharmacological interventions for cognitive dysfunction in MDD
19 Claudia Woolf, Loren Mowszowski, and Sharon Naismith: Psychological interventions for cognitive dysfunction in MDD
20 Can non-pharmacological antidepressant treatments influence the processing of affective informationa
21 Michael James Weightman and Bernhard T. Baune: Novel treatment opportunities in major depressive disorder

About the author: 

Prof. Bernhard T. Baune is Cato Chair and Head of the Department of Psychiatry at The University of Melbourne, Australia. Prof. Baune is a Fellow of the Royal Australian and New Zealand College of Psychiatrists (FRANZCP), Australia. He leads an extensive research program into personalised psychiatry, prediction and biomarker research in psychiatry and treatment response prediction and in neuroimmunology. Key research achievements include an in-depth understanding of the interaction between the immune and nervous system, the development of a systems biology approach for response prediction and the establishment of innovative personalised clinical trials in major psychiatric disorders. He has a particular interest in cognitive function and psychosocial function in psychiatric disorders and in the severe course of mental illness, treatment response and recovery.; Prof. Catherine Harmer is the director of the Psychopharmacology and Emotional Research Lab (PERL) based at the University Department of Psychiatry in Oxford, which comprises a multi-disciplinary team including graduate research assistants, DPhil students, post-doctoral researchers, Psychiatrists and Pharmacologists. The research of the group focuses on the psychological mechanisms of antidepressant drug action by exploring drug effects on human models of emotional processing. A range of methodologies are used, including neuropsychological testing, transcranial magnetic stimulation and functional neuroimaging with fMRI and PET in healthy volunteers and patient samples. This research has the potential to integrate psychological and pharmacological views of depression and treatment and has challenged the way in which we typically consider drug treatment for depression to work.

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