Psychiatric Genetics: A Primer for Clinical and Basic Scientists

ISBN : 9780190221973

Thomas Schulze; Francis McMahon
240 Pages
140 x 210 mm
Pub date
Apr 2018
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Psychiatric Genetics: A Primer for Clinical and Basic Scientists offers a straightforward introduction to the essentials of psychiatric genetics, covering basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of take home points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading.


Chapter 1: Contribution of Epidemiology to Our Understanding of Psychiatric Genetics
Alison K. Merikangas and Kathleen R. Merikangas
Chapter 2: Recruitment of Human Subjects: An overview of techniques and methods used in psychiatric and other clinical studies
Layla Kassem
Chapter 3: Basic molecular genetics concepts and tools: from SNPs to chips
Sevilla D Detera-Wadleigh, Nirmala Akula, and Liping Hou
Chapter 4: Statistical genetics: Genome-wide studies
Till F.M. Andlauer, Bertram Muller-Myhsok, and Stephan Ripke
Chapter 5: Human Linkage and Association Analysis
John P. Rice
Chapter 6: The role of copy number variation in psychiatric disorders
Elliott Rees and George Kirov
Chapter 7: Pharmacogenomics & Precision Psychiatry
Julia C. Stingl and Gonzalo Laje
Chapter 8. Endophenotypes
David C. Glahn, Laura Almasy, and John Blangero
Chapter 9: Imaging Genetics
Luanna Dixson, Heike Tost, and Andreas Meyer-Lindenberg
Chapter 10: Bioinformatics in psychiatric genetics
Nikola S. Mueller, Ivan Kondofersky, Gokcen Eraslan, Karolina Worf, and Fabian J. Theis
Chapter 11: Epigenomic Exploration of the Human Brain
Tobias B. Halene, Gregor Hasler, Amanda Mitchell, and Schahram Akbarian
Chapter 12: Epigenetics in Psychiatry
Subha Subramanian and James B. Potash
Chapter 13: Next-generation sequencing in genetic studies of psychiatric disorders
Shweta Ramdas and Jun Z. Li
Chapter 14: Animal Models
Tadafumi Kato
Chapter 15: Biobanking of Human Induced Pluripotent Stem Cells for Psychiatric Research
Jennifer C. Moore, Michael Sheldon, and Jay A. Tischfield

About the author: 

Professor Thomas G. Schulze, MD studied medicine in Germany, the USA, and Catalonia. He trained as a psychiatrist and has held positions in Germany and the USA. Since 2014, he has held the position of Director of the Institute of Psychiatric Phenomics and Genomics at the Ludwig-Maximilans-University of Munich (IPPG). He currently serves as the President of the International Society of Psychiatric Genetics (ISPG).; Professor Francis J. McMahon, MD received his medical degree from Johns Hopkins in 1987, where he also completed a medical internship, a residency in adult psychiatry, and a post-doctoral fellowship in genetics. He is a Senior Investigator and Chief of the Human Genetics Branch in the National Institute of Mental Health Intramural Research Program at the US National Institutes of Health. He is also a visiting Professor of Psychiatry at the Johns Hopkins University School of Medicine and past president of the ISPG.

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