Neuropathic Pain: Mechanisms, Diagnosis and Treatment

ISBN : 9780195394702

Robert H. Dworkin; David M. Simpson; Justin C. McArthur
544 Pages
218 x 255 mm
Pub date
Jun 2012
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The incidence of neuropathic pain continues to rise, yet it is an affliction often misdiagnosed or inadequately treated. Although in recent years considerable research has been dedicated to understanding its mechanisms, there have been few advances in treatment. The contributors to this book are internationally renowned leaders in the fields of peripheral neuropathy and neuropathic pain. They discuss clinical approaches to diagnosis and treatment of neuropathic pain, its underlying mechanisms, and strategies for prevention. In addition, chapters cover timely issues, including legal and ethical concerns surrounding pain treatment, the status of clinical trial methods, and educational efforts. Comprehensive yet concise, this book serves as a guide for diagnostic approaches and treatment of neuropathic pain for the student, resident, practicing physician, researcher, and specialist.


1. Neuropathic Pain: A Brief Conceptual History
2. Peripheral and Central Mechanisms of Neuropathic Pain
3. Experimental Approaches to Neuropathic Pain
4. Drug Discovery for Neuropathic Pain
5. Definitions, Anatomical Localization, Signs and Symptoms of Neuropathic Pain
6. Diagnostic Testing: NCS, QST, Autonomic Testing, Skin/Nerve BX, Pain Scales
7. Psychosocial Aspects of Neuropathic Pain
8. Pharmacology of Neuropathic Pain
9. Understanding and Interpreting Neuropathic Pain Clinical Trials
10. Ethical, Legal and Social Issues in the Management of Neuropathic Pain
11. Painful Diabetic Neuropathy
12. HIV-Associated Distal Symmetric Polyneuropathy
13. Heritable Neuropathies
14. Cancer Associated Neuropathic Pain and Paraneoplastic Syndromes
15. Herpes Zoster and Postherepetic Neuralgia
16. Immune Mediated Neuropathies
17. Entrapment Syndromes
18. Traumatic Peripheral Nerve Injuries
19. Chronic Postsurgical Pain
20. Central Neuropathic Pain
21. Spinal Root Disease: Radiculopathy and Arachnoiditis
22. The Complex Regional Pain Syndrome
23. Trigeminal Neuralgia and Atypical Facial Pain
24. Metabolic, Endocrine, and Other Toxic Neuropathies
25. Complementary and Alternative Medicine for Neuropathic Pain
26. Neuropathic Pain: An Interdisciplinary Rehabilitation Approach
27. Preventing Neuropathic Pain in Experimental Models and Predictable Clinical Settings
28. Peripheral Neuropathy: Educating Patients and Providers

About the author: 

David M. Simpson, MD is Professor of Neurology and Director of Neuromuscular Division, Director of Clinical Neurophysiology Laboratories, and Director of Neuro-AIDS Program at Mount Sinai Medical Center in New York. Justin C. McArthur, MBBS, MPH is Professor of Neurology, Pathology and Epidemiology and Director of Department of Neurology at Johns Hopkins University School of Medicine in Baltiomore, Maryland. Robert H. Dworkin, PhD, is Professor of Anesthesiology, Neurology, Oncology, and Psychiatry, and Professor at the Center for Human Experimental Therapeutics at the University of Rochester School of Medicine and Dentistry in Rochester, New York.

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