Charney & Nestler's Neurobiology of Mental Illness (5th edition)

ISBN : 9780190681425

Dennis S. Charney; Eric J. Nestler; Pamela Sklar; Joseph D. Buxbaum
1040 Pages
216 x 279 mm
Pub date
Jan 2018
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In the years following publication of the DSM-5RG, the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler's Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis. In this wider context, this book provides information from numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Sections and chapters are edited and authored by experts at the top of their fields. No other book distills the basic science and underpinnings of mental disorders-and highlights practical clinical significance-to the scope and breadth of this classic text. In this edition, Section 1, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect critically important technical advances in complex genetics (including powerful sequencing technologies and related bioinformatics), epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. This range of established and emerging methodologies offer groundbreaking advances in our ability to study the brain as well as unique opportunities for the translation of preclinical and clinical research into badly needed breakthroughs in our therapeutic toolkit. Sections 2 through 7 cover the neurobiology and genetics of major psychiatric disorders: psychoses (including bipolar disorder), mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. Each of these parts has been augmented in several different areas as a reflection of research progress. The last section, Section 8, reconfigured in this new edition, now focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5RG, which forms the basis of psychiatric diagnosis in the United States for all clinical work, and of RDoC, which provides an alternative perspective on diagnosis in heavy use in the research community. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.


Section 1: Emerging and Established Technologies; 1. Genetic Methodologies and Applications; Shaun M. Purcell; 2. Network Methods for Elucidating the Complexity of Common Human Diseases; Eric E. Schadt; 3. The Human Brain and its Epigenome; Andrew Chess and Schahram Akbarian; 4. Methods for In Vivo Gene Manipulation; Lisa M. Monteggia and Wei Xu; 5. Application of Stem Cells to Understanding Psychiatric Disorders; Zijia Zhang and Kristen Brennand; 6. Optogenetics and Related Technologies for Psychiatric Disease Research: Current Status and Challenges; Lief E. Fenno and Karl Deisseroth; 7. In Vivo Circuit Analysis; Ryan Bowman, Hannah Schwennsen, Kafui Dzirasa, and Rainbo Hultman; 8. Magnetic Resonance Methodologies; Peter A. Bandettini and Hanzhang Lu; 9. PET Brain Imaging Methodologies; Ansel T. Hillmer, Kelly P. Cosgrove, and Richard E. Carson; 10. Neuromodulation and Psychiatric Disorders; Wayne K. Goodman and Mark S. George; 11. The Neurobiology of Sleep; Giulio Tononi and Chiara Cirelli; Section 2: Psychotic Disorders; 12. Diagnosis and Epidemiology of Psychotic Disorders; Emma Meyer, Julie Walsh-Messinger, and Dolores Malaspina; 13. Genetics of Schizophrenia and Bipolar Disorder; Pamela Sklar; 14. Neuroimaging of Psychotic Disorders; Stephan Heckers, Neil Woodward, and Dost Ongur; 15. Animal and Cellular Models of Psychotic Disorders; Mikhail V. Pletnikov, Guo-Li Ming, and Christopher A. Ross; 16. Cognitive and Motivational Neuroscience of Psychotic Disorders: Animal and Human Studies; Jared Young, Alan Anticevic, and Deanna M. Barch; 17. Synaptic Mechanisms of Psychotic Disorders: Animal and Human Studies; Seth G. N. Grant; 18. Cellular Mechanisms of Psychotic Disorders: Human Studies; Samuel J. Dienel and David A. Lewis; 19. Neurodevelopmental Mechanisms for Psychotic Disorders: Animal and Human Studies; Nao J. Gamo, Takeshi Sakurai, Hanna Jaaro-Peled, and Akira Sawa; 20. The Neurobiology and Treatment of Bipolar Disorder; Katherine E. Burdick, Luz H. Ospina, Stephen J. Haggarty, and Roy H. Perlis; 21. Novel Approaches for Treating Psychotic Disorders; Tiago Reis Marques and Shitij Kapur; 22. Current Treatments for Psychotic Disorders; Deepak K. Sarpal and Anil K. Malhotra; Section 3: Depression; 23. Diagnosis and Epidemiology of Depression; Nicholas T. Van Dam, Brian M. Iacoviello, and James W. Murrough; 24. Genetics of Depression; Douglas F. Levinson and Walter E. Nichols; 25. Neuroimaging of Depression; Michele A. Bertocci and Mary L. Phillips; 26. Animal Models of Mood Disorders; Lyonna F. Alcantara, Eric M. Parise, and Carlos A. Bolanos-Guzman; 27. Neurotrophic Mechanisms of Depression: Animal and Human Studies; Ronald S. Duman; 28. Immune Mechanisms of Depression; Caroline Menard, Madeline L. Pfau, Georgia E. Hodes, and Scott J. Russo; 29. Neuroendocrine Mechanisms of Depression: Clinical and Preclinical Evidence; Jill M. Goldstein, L Holsen, S Cherkerzian, M Misra, and RJ Handra; 30. New Approaches for Treating Depression; Eric J. Nestler; 31. Current Treatments for Depression; John H. Krystal and Dennis S. Charney; Section 4: Anxiety Disorders; 32. Diagnosis and Epidemiology of Anxiety, Obsessive-Compulsive and Trauma- and Stressor-Related Disorders; Murray B. Stein, Meghan E. Keough, and Peter P. Roy-Byrne; 33. Genetics of Anxiety Disorders; Takeshi Otowa, Roxann Roberson-Nay, Mandy Bekhbat, Gretchen N. Neigh, and John M. Hettema; 34. Functional Neurocircuitry and Neuroimaging Studies of Anxiety Disorders; Madeleine S. Goodkind and Amit Etkin; 35. Animal Models and Assays Probing anxiety Related Behaviors and Neural Circuits; Ramon Tasan and Nicholas Singewald; 36. Distinct Neural Mechanisms Underlying Fear and Anxiety; Joseph LeDoux; 37. Synaptic and Circuit Mechanisms of Anxiety Disorders: Animal and Human Studies; Anfei Li, Francis S. Lee; 38. The Neurobiology of Resilience; Adriana Feder, Sarah R. Horn, Margaret Haglund, Steven M. Southwick, and Dennis S. Charney; 39. Novel Approaches for Treating Anxiety Disorders; David A. Sturman,Milissa L. Kaufman, Cara E. Bigony, and Kerry J. Ressler; 40. Novel treatment approaches for anxiety disorders; Adam J. Guastella, Alice Norton, Gail A. Alvares, and Christine Song; Section 5: Substance Use Disorders; 41. Epidemiology of Substance Use Disorders; Denise B. Kandel, Mei-Chen Hu, Pamela C. Griesler, Bradley T. Kerridge, and Bridget F. Grant; 42. The Genetic Basis of Addictive Disorders; David Goldman, Zhifeng Zhou, and Colin Hodgkinson; 43. Animal Models of Addiction; Christopher Evans J., Brigitte L. Lieffer, David Jentsch, and Rafael J. Maldonado; 44. Reward Circuitry and Drug Addiction; Vaughn R. Steele, Vani Pariyadath, Rita Z. Goldstein, and Elliot A. Stein; 45. Molecular Neuroimaging in Addictive Disorders; Edythe D. London and Chelsea L. Robertson; 46. Cellular and Molecular Mechanisms of Addiction; Kathryn J. Reissner and Peter W. Kalivas; 47. Brain Development and the Risk for Substance Abuse; Mary M. Heitzeg and B.J. Casey; 48. Pharmacotherapy of Substance Use Disorders; Jane B. Acri and Phil Skolnick; 49. Current Approved Pharmacotherapies for Substance Use Disorders; Alexis S. Hammond and Eric C. Strain; Section 6: Dementia; 50. Diagnosis and Epidemiology of Dementia; William C. Kreisl and Christiane Reitz; 51. Genetics of Dementia; Alan E. Renton and Alison M. Goate; 52. Neuroimaging and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease; Brian A. Gordon, Stephanie J.B. Vos, and Anne M. Fagan; 53. Animal Models of Alzheimer's Disease; David Morgan; 54. Cellular Mechanisms of Dementia: Animal and Human Studies; Li Gan; 55. Neurobiology of Lewy Body Dementias: Animal and Human Studies; James E. Galvin and Jose Tomas Bras; 56. Neurobiology of FTD: Animal and Human Studies; Dah-eun Chloe Chung, Jeannette N. Stankowski, and Leonard Petrucelli; 57. Current Treatments for Alzheimer's Disease; Mary Sano and Judith Neugroschil; Section 7: Psychiatric Disorders of Childhood Onset; 58. Diagnosis and Epidemiology of Pediatric Psychiatric Disorders of Childhood; Elise Robinson, Benjamin Neale, and Mark Daly; 59. Genetics of Pediatric Psychiatric Disorders; Silvia de Rubeis, M. Pilar Trelles, and Joseph D. Buxbaum; 60. Neuroimaging in Pediatric Psychiatric Disorder; Timothy P.L. Roberts and Luke Bloy; 61. Animal and Cellular Models of Pediatric Psychiatric Disorders; Elodie Drapeau, Hala Harony-Nicolas, and Jacqueline N. Crawley; 62. Neurodevelopmental Mechanisms of Pediatric Psychiatric Disorders: Animal and Human Studies; Silvia De Rubeis, Kathryn Roeder, and Bernie Devlin; 63. Neurobiology of Autism Spectrum Disorder and Intellectual Disability: Animal and Human Studies; Jesse Costales, Silvia De Rubeis, Jennifer Foss-Feig, Patrick Hof, Joseph D. Buxbaum, and Alexander Kolezvon; 64. Neurobiology of Attention Deficit Hyperactivity Disorder: Animal and Human Studies; Stephen V. Faraone, Pradeep G. Bhide, and Joseph Biederman; 65. The Neurobiology of Tic Disorders and Obsessive-Compulsive Disorder: Human and Animal Studies; Christopher Pittenger; 66. Neurobiology of Eating Disorders: Animal and Human Studies; Thomas Hildebrandt and Ashley Heywood; 67. Novel Approaches for Treating Pediatric Psychiatric Disorders; Supritha Prasad and Edwin H. Cook, Jr.; 68. Current Treatments for Pediatric Psychiatric Disorders; M. Pilar Trelles, Paige Siper, and Dorothy Grice; Section 8: Future of Psychiatric Diagnosis: Toward Precision Psychiatry; 69. DSM-5RG Overview and Goals; Darrel A. Regier, Sarah E. Morris, and Susan K. Schulz; 70. The Present and Future of Psychiatric Diagnosis; Steven E. Hyman; 71. The NIMN Research Domain Criteria Project: Toward Precision Medicine in Psychiatry; Bruce N. Cuthbert; 72. Computational Psychiatry and the Bayesian Brain; Karl J. Friston and Raymond J. Dolan

About the author: 

Dennis S. Charney, MD Anne and Joel Ehrenkranz, Dean, Icahn School of Medicine at Mount Sinai President for Academic Affairs Mount Sinai Health System Professor, Departments of Psychiatry, Neuroscience, and Pharmacological Sciences New York, NY; Joseph D. Buxbaum, PhD G. Harold and Leila Y. Mathers Professor, Departments of Psychiatry, Neuroscience, and Genetics and Genomic Sciences Deputy chair, department of psychiatry Director, Seaver Autism Center for research and treatment Icahn School of Medicine at Mount Sinai New York, NY; Pamela Sklar, MD, PhD Mount Sinai professor of Psychiatric genomics Chair, department of Genetics and Genomic Sciences Professor, Departments of Genetics and Genomic Sciences, Psychiatry, Neuroscience, and Director, Center for Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York, NY; Eric J. Nestler, MD, PhD Nash Family Professor Departments of Neuroscience and Psychiatry Director, The Friedman Brain Institute Dean for academic and scientific affairs Icahn School of Medicine at Mount Sinai New York, NY

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