Imaging in Parkinson's Disease

ISBN : 9780195393484

David Eidelberg
224 Pages
222 x 287 mm
Pub date
Sep 2011
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Imaging in Parkinson's Disease provides up-to-date information concerning new applications of brain imaging to the study of Parkinson's disease. Written by experts in the field, the book focuses on structural and functional imaging methodologies that have recently been applied to study the natural history of Parkinson's disease, with emphasis on the development of the major motor manifestations of the illness as well as cognitive impairment and dementia. Individual chapters address the role of imaging in differential diagnosis and in the evaluation of pharmacologic and surgical treatment effects. In-depth discussion of the use of imaging tools to study disease mechanisms is also provided, with emphasis on the roles of neuroinflammation, protein aggregation, and abnormal network organization in parkinsonism. Additionally, the text covers a number of relevant novel topics including recent advances in volumetric and functional MRI, echosonography, dopaminergic and cholinergic neurotransmitter imaging, and applications to experimental interventions such as gene therapy and transplantation. Covering a wide range of subjects and beautifully illustrated, Imaging in Parkinson's Disease is a valuable reference for neurologists, neurosurgeons and neuropsychologists, and a helpful resource for students engaged in postgraduate biomedical and clinical training.


Chapter 1: Dopaminergic Imaging in Parkinson's DiseaseD: PET, A. Jon Stoessl and Biju Gopalakrishnan
Chapter 2: Dopaminergic Imaging in Parkinson's DiseaseD: SPECT, Christoph Scherfler and Werner Poewe
Chapter 3: Cerebral Glucose Metabolism and Blood Flow in Parkinson's Disease, Yilong Ma, Schichun Peng, Vijay Dhawan, and David Eidelberg
Chapter 4: Structural Abnormalities in Parkinson's Disease: MRI and Related Methods, Kathrin Reetz and Ferdinand Binkofski
Chapter 5: Transcranial Sonography in Parkinsonian Syndromes, Daniela Berg
Chapter 6: Parkinsonian Tremor, Ioannis U. Isaias and Angelo Antonini
Chapter 7: Atypical Parkinsonian Syndromes, Kathleen L. Poston
Chapter 8: Brain Activation Studies in Parkinson's Disease, L.K. Prashanth and Antonio P. Strafella
Chapter 9: Functional Markers of Cognition in Parkinson's Disease: 18F-FDG and H215O Positron Emission Tomography Studies, Paul Mattis and Maren Carbon
Chapter 10: Imaging Cognitive Dysfunction in Parkinson's Disease: Cholinergic Neurotransmission and Protein Aggregation, Nicholaas I. Bohnen and Kirk A. Frey
Chapter 11: Imaging Inflammation in Parkinsonian Syndromes, David J. Brooks
Chapter 12: Functional Imaging Biomarkers for the Assessment of Parkinson's Disease Progression, Chris C. Tang and David Eidelberg
Chapter 13: Effects of Treatment: Pharmacologic, Alain Dagher
Chapter 14: Neuroimaging in Levodopa Induced Dyskinesia, Shigeki Hirano
Chapter 15: Effects of Surgical Treatment, Anna L. Bartels and Klaus L. Leenders
Chapter 16: Cell-Based Therapies: Imaging Outcomes, Paola Piccini and Marios Politis
Chapter 17: Imaging Applications to Parkinson's Disease Clinical Trials, Martin Niethammer and Andrew Feigin
Chapter 18: Clinical Applications, Kathleen L. Poston

About the author: 

David Eidelberg received his MD from Harvard Medical School in 1981. After completing residency training in neurology at Harvard, he pursued fellowship training in functional brain imaging research in London and New York. He is currently Head of the Center for Neurosciences at The Feinstein Institute for Medical Research. He is also director of the new NIH Morris K. Udall Center for Parkinson's Disease Research and Susan and Leonard Feinstein Professor of Neuroscience at The Feinstein Institute. ; He also serves on the editorial boards of several major journals including Annals of Neurology and is Associate Editor of The Journal of Neuroscience.

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