OXFORD UNIVERSITY PRESS

Frontotemporal Dementia

ISBN : 9780195380491

Price(incl.tax): 
¥25,410
Author: 
Bruce L. Miller
Pages
200 Pages
Format
Hardcover
Size
184 x 256 mm
Pub date
Oct 2013
Series
Contemporary Neurology Series
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Frontotemporal Dementia provides an in-depth look at the history, various types, genetics, neuropathology and psychosocial aspects of one of the most common but least understood causes of dementia, frontotemporal lobar degeneration, from one of the world's leading centers for the study of dementia. Aided by the latest research in diagnosis, mechanism and treatment, this book captures the rich and quickly changing landscape of a devastating neurodegenerative disease, and offers up-to-date clinical advice for patient care. Frontotemporal dementia, in particular, raises psychological and philosophical questions about the nature of self, free will, emotion, art and behavior - important topics for practitioners and families to appreciate as they care for the sufferer. This book includes case studies, photographs and figures from the leaders in the field and personal communication from the researchers driving these developments.

Index: 

Table of Contents
1. History and Nomenclature
Pick's Disease: The Contributions of Arnold Pick
Maintaining Early Traditions and Refining Diagnosis: Delay, Brion, Escourolle, Malamud and Constantinidis
Splintering of Pick's Disease into Multiple Subtypes
The Biological Revolution
FTD Now: Where Are We?
The Future
References
2. The Clinical Syndrome of bvFTD
Overview
Clinical Features and Anatomy
Genetic and Pathological Correlates
Differential Diagnosis
Treatment
BVFTD: Current State And Research Advances
References
3.The Clinical Syndrome of NFVPPA
Overview
Clinical Features and Anatomy
Genetic and Pathological Correlates
Differential Diagnosis
Treatment
NFVPPA: Current State And Research Advances
References
Related Disorders: FTD-ALS
Overview
Amyotrophic Lateral Sclerosis
Clinical Features and Anatomy
Genetic and Pathological Correlates
Differential Diagnosis
Treatment
FTD-ALS: Current State and Research Advances
References
6. Related Disorders: Corticobasal Degeneration and Progressive Supranuclear Palsy
Overview
Creativity
Treatment
svPPA: Current State and Research Advances
Semantic Knowledge and the Anterior Temporal Lobes
Autoimmunity, Left-Handedness, Head Trauma and svPPA
Summary
References
4. Progressive Nonfluent/Agrammatic Aphasia
Overview
Case History
Comment
Clinical Features and Anatomy
Genetic and Pathological Correlates
Differential Diagnosis
Treatment
nfvPPA: Current State and Research Advances
Diagnosis from Clinical Syndrome to Molecular Diagnosis
Neurolinguistic and Neuroplasticity Discoveries
References
5. Related Disorders: FTD-ALS
Overview
Amyotrophic Lateral Sclerosis
Case History
Comment
Clinical Features and Anatomy
El Escorial Criteria
Genetic and Pathological Correlates
Neuropathology
Differential Diagnosis
Treatment
FTD-ALS: Current State and Research Advances
Clinical-Pathological Considerations
Molecular Considerations
References
6. Related Disorders: Corticobasal Degeneration and Progressive Supranuclear Palsy
Overview
Corticobasal Degeneration (CBD)
Clinical Features and Anatomy
Genetic and Pathological Correlates
Differential Diagnosis
Treatment
Progressive Supranuclear Palsy (PSP)
Clinical Features and Anatomy
Genetic and Pathological Correlates
Differential Diagnosis
Treatment
CBD and PSP: Current State and Research Advances
References
7. A Primer of FTLD Neuropathology
General Features
Overview of Tau-Related Neuropathology in FTLD
Overview of TDP-43 and FUS Related Neuropathology in FTLD
Gross Anatomical and Microscopic Changes in FTLD
Special Features of FTLD Pathology
FTLD Neuropatholoy: Current State and Research Advances
8. FTD Genes
Overview
Genes Implicated in FTD
Genes That Modify FTD Expression
Management and Genetic Counseling
References
9. FTD Reflections Upon Psychology and Philosophy
Emotions
The Self
Free Will
Religious Beliefs
Psychology
von Economo Neurons
References
10. Treatments
Diagnosis
bvFTD: Targeting Symptoms, Educating the Family
svPPA: Targeting Symptoms, Educating the Family
nfvPPA: Targeting Symptoms and Educating the Family
Late Stages of FTD
Early Interventions
Pharmacological Review
Non-Pharmacological Therapies
Complementary and Alternative Medicine
Language Impairment
Future Treatments
Conclusions
References

About the author: 

Bruce L. Miller, MD is Professor of Neurology at the University of California, San Francisco (UCSF) where he holds the A.W. & Mary Margaret Clausen Distinguished Chair, teaches extensively and directs the busy UCSF dementia center. He is a behavioral neurologist focused in dementia with special interests in brain and behavior relationships as well as the genetic and molecular underpinnings of disease.

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