Genomics and Health in the Developing World

ISBN : 9780195374759

Dhavendra Kumar
1536 Pages
224 x 279 mm
Pub date
Jun 2012
Oxford Monographs on Medical Genetics
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Genomics and Health in the Developing World provides detailed and comprehensive coverage of population structures, human genomics, and genome variation - with particular emphasis on medical and health issues - in the emerging economies and countries of the developing world. With sections dedicated to fundamentals of genetics and genomics, epidemiology of human disease, biomarkers, comparative genomics, developments in translational genomic medicine, current and future health strategies related to genetic disease, and pertinent legislative and social factors, this volume highlights the importance of utilizing genetics/genomics knowledge to promote and achieve optimal health in the developing world. Grouped by geographic region, the chapters in this volume address: - Inherited disorders in the developing world, including a thorough look at genetic disorders in minority groups of every continent - The progress of diagnostic laboratory genetic testing, prenatal screening, and genetic counseling worldwide - Rising ethical and legal concerns of medical genetics in the developing world - Social, cultural, and religious issues related to genetic diseases across continents Both timely and vastly informative, this book is a unique and comprehensive resource for genetists, clinicians, and public health professionals interested in the social, ethical, economic, and legal matters associated with medical genetics in the developing world.


Part I: Genomics in Medicine and Health-General
1. Genes and Genomes in Health and Disease: An Introduction
Dhavendra Kumar
2. The Human Variome Project and the Developing World
Richard G.H. Cotton
3. Human Genomic Variation Initiatives in Emerging Economies and Developing Countries
Beatrice Seguin, Billie-Jo Hardy, Peter A. Singer, and Abdallah S. Daar
4. The Genomic Map of Population Diversity in Asia
Dhavendra Kumar
5. Ancestry, Disease and Variable Drug Response in the Genomic Era
Charles Rotimi and Lynn Jorde
6. The Next Steps for Genomic Medicine: Challenges and Opportunities for the Developing World
Billie-Jo Hardy, Beatrice Seguin, Federico Goodsaid, Gerardo Jimenez-Sanchez, Peter A. Singer, and Abdallah S. Daar
7. Consumer Perspectives on Genomics and Healthcare
Alastair Kent
8. Transcultural Perspectives on Genetics and Genomics
Dhavendra Kumar
9. Medical Genetics and Genomics Research in the Muslim World
Aida I. Al-Aqeel
10. The Progress of Genomics in the Developing World: Rising Social, Economic, and Ethical Concerns
Minakshi Bhardwaj
11. Genetic Outcomes of Consanguineous Marriages
Alan H. Bittles and Michael L. Black
12. Autosomal Recessive Conditions and Autozygosity Mapping
Colin A. Johnson and Eamonn R. Maher
13. Genetic Contribution to Malaria Susceptibility and Resistance
Susana G. Campino and Taane G. Clark
14. Glucose 6-Phosphate Dehydrogenase Deficiency: Genetics, Pharmacogenetics, and Malaria Selection
Lucio Luzzatto
15. Infections, Genomics, and Global Public Health
Tikki Pang
16. Microbial Genomics and Global Health
Rino Rappuoli
17. Pharmacogenetics and Pharmacogenomics in the Developing World
Warren E. Hochfeld, Sahle M. Asfaha, Marco Alessandrini, Tyren M. Dodgen, Renier Myburgh, Arinda Eloff, and Michael S. Pepper
18. Nutrigenomic Research in World Populations
Jim Kaput
19. Transgenic Foods and Nutritional Health in Developing Countries
Dhavendra Kumar and Joel Cohen
20. The Burden of Inherited Disease in the Developing World: The Example of Inherited Blood Diseases
David J. Weatherall
21. Health Implications of Inherited Disorders of Iron Overload
Chun Yo Lok, Alison T. Merryweather-Clarke, and Kathryn J.H. Robson
22. Inherited Factors in Diabetes Mellitus and Related Metabolic Disorders in the Developing World
Dwaipayan Bharadwaj, Nikhil Tandon, and Anubha Mahajan
23. Global Health Implications of Genetic Studies of Obesity and Type 2 Diabetes
Jessica Buxton, Julia El-Sayed Moustafa, Haya Al-Saud, and Alexandra Blakemore
24. Health Implications of Familial Hyperlipidemia
Deepak Bhatnagar
25. Global Health Implications of Inherited Renal Diseases
Wendy Jones and Anand Saggar
26. The Burden of Congenital Anomalies on Global Health
Dhavendra Kumar
27. Inherited Eye Diseases in Developing Countries
Tiziana Cogliati, James Friedman, Norimoto Gotoh, Neeraj Agarwal, and Anand Swaroop
28. Principles and Practice of Newborn Screening-The Lessons from the Developed World
Rodney J. Pollitt
29. Diagnostic Laboratory Genetic Testing - Models for the Developing World
Peter Lunt
30. Ethical Issues Arising in Medical Genetics in Developing Countries
Angus Clarke
31. Genetic and Genomics Services in Emerging Economies of the Developing World
Robert George Elles
Part II: Genomics in Medicine and Health-Regional
32. Anthropology and Population Heterogeneity in North Africa
Rym Kefi
33. The Genetic Landscape of Sub-Saharan African Populations
Himla Soodyall and Carina M. Schlebusch
34. Genetic Disorders in North African Populations
Romdhane Lilia and Abdelhak Sonia
35. Genetic Neurological Diseases in Tunisia
Neziha Gouider-Khouja and Ibtihel Rebai
36. Hemoglobinopathies in Africa
Ambroise Wonkam and Amanda Krause
37. The Burden of Birth Defects and Genetic Disease in Sub-Saharan Africa
Ambroise Wonkam
38. Genetic Epidemiology of South Atlantic Oceanic Islands
Peter Beighton
39. Genetic Disorders in Minority Groups in South Africa
Peter Beighton
40. Hereditary Deafness in Southern Africa
Peter Beighton and Sean Sellars
41. Heritable Disorders of the Skeleton in South Africa
Peter Beighton
42. Heritable Disorders of Connective Tissue in South Africa
Peter Beighton
43. Genetic Perspectives of Tuberculosis in Southern Africa
Erika de Wit, Marlo Moller, and Eileen Hoal
44. Familial Cancer Syndromes in Africa
Yonglan Zheng, Toshio F. Yoshimatsu, and Olufunmilayo I. Olopade
45. Genetic Counseling in South Africa
Jacquie Greenberg, Jennifer Kromberg, Kelly Loggenberg, and Tina-Marie Wessels
46. Prenatal Diagnostic Services and Prevention of Birth Defects in South Africa
Michael Urban and Lut Geerts
47. Sociocultural Perspectives of Inherited Diseases in Southern Africa
Claire Penn and Jennifer Watermeyer
48. Ethical, Legal, and SocioCultural Issues and Genetic Services in Southern Africa
Jennifer G.R. Kromberg and Trefor Jenkins
49. The Genomic Research and Health Applications in South Africa
Billie-Jo Hardy, Beatrice Seguin, Raj Ramesar, Peter A. Singer and Abdallah S. Daar
Arab and Middle East
50. Hereditary Disorders in Arabs
Ghazi Omar Tadmouri and Mahmoud Taleb Al Ali
51. Community Health Implications of Consanguinity in Arab Populations
Ghazi O. Tadmouri, Pratibha Nair, Tasneem Obeid, and Hanan Hamamy
52. Clinical Dysmorphology in the Arab World
Lihadh Al-Gazali and Hanan Hamamy
53. The Population Genetics and Hereditary Diseases of Bahrain
Shaikha Salim Al-Arrayed
54. Genetic Diseases in the Sultanate of Oman
Anna Rajab and Michael A.Patton
55. Genetic Disorders in Lebanon: Challenges and Opportunities
Issam I. Khneisser, Salim. M. Adib, and Andre Megarbane
56. Genetic Disease in Palestine and Palestinians
Bassam Abu-Libdeh, Peter D. Turnpenny, and Ahmed Teebi
57. Genetic Skin Diseases in the Arab World
Mourad Mokni, Cherine Charfeddine, and Sonia Abdelhak
58. Hereditary Diseases of the Nervous System in Arabs
Nisrine Bissar-Tadmouri, Mohamad Al-Homssi, and Pratiba Nair
59. Preimplantation Genetic Diagnosis in Saudi Arabia
Serdar Coskun, Wafa Qubbaj, and Aida I. Al-Aqeel
60. Genomics for Universal Healthcare in Thailand
Beatrice Seguin, Billie-Jo Hardy, Peter A. Singer, and Abdallah S. Daar
61. Screening Newborns in the Asia-Pacific Region
Carmencita D. Padilla and Bradford L. Therrell
62. Clinical Dysmorphology and Birth Defects Registry in the Asia-Pacific Region
Meow Keong Thong
63. Prevention and Control of Thalassemia in Thailand
Chanane Wanapirak, Jintana Pattanapongthorn, Pranee Winichagoon, and Suthat Fucharoen
64. Inherited Metabolic Disorders in Thailand and the Asia-Pacific
Pornswan Wasant
65. Genetic Skeletal Dysplasias in Thailand
Pornswan Wasant
66. Medical Genetic Services in the Philippines
Carmencita Padilla, Eva Maria Cutiongco-de la Paz, and Catherine Lynn Silao
Chinese Subcontinent
67. Community and Public Health Genetics in China
Manshu Song, Youxin Wang, Lijuan Wu, Yun Wang, and Wei Wang
68. Genetic Epidemiology in China
Peng-Gao Li, Yan He and Wei Wang
69. Traditional Chinese Medicine in the Area of Genomics
Hong-Min Yun, Manshu Song, and Wei Wang
70. Inherited Factors in Cardiovascular Disease in China
Ling Zhang Ying Dai, and Wei Wang
71. Familial and Genetic Cancer in China
Fen Liu and Wei Wang
72. Genomic Medicine in Taiwan: Research and Developments
Ming Ta Michael Lee, Chien-Hsiun Chen, and Yuan-Tsong Chen
Indian Subcontinent
73. The Indian Subcontinent and its People
Dhavendra Kumar
74. Genomic Perspectives of Peopling and Languages of the Indian Subcontinent
Ganesh Prasad Arunkumar, Varatharajan Santhakumari Arun, Adhikarla Syama, Valampuri John Mary Selvam Kavitha, and Ramasamy M. Pitchappan
75. Genomic Diversity of HLA in the Indian Subcontinent
Narinder K. Mehra and Gurvinder Kaur
76. Genomic Applications in Medicine and Health in India
Billie-Jo Hardy, Beatrice Seguin, Peter A. Singer, Mitali Mukerji, Samir K. Brahmachari and Abdallah S. Daar
77. Epidemiology of Genetic Diseases in the Indian Subcontinent
Ishwar C. Verma and Dhavendra Kumar
78. Genetic Services in India: A Model for Developing Countries
Ratna D. Puri and Ishwar C. Verma
79. The Practice of Genetic Counseling in India
Meenakshi Bhatt
80. Social and Cultural Aspects of Customary Consanguineous Marriages in South Asia
Rafat Hussain
81. Medical Genetics and Genomics in Sri Lanka
Vajira H.W. Dissanayake
82. Inherited Factors in Obstructive Lung Diseases in India
Amrendra Kumar Gupta, Balaram Ghosh, and Anurag Agrawal
83. Inherited Metabolic Disease in India
Bal N. Apte
84. Genetic Variation and Genetic Epidemiology of Sri Lanka
Deepthi C. de Silva
85. Familial Cancer and Cancer Genetics in the Indian Subcontinent
Dhavendra Kumar
86. Inherited Disorders of the Eye in the Indian Subcontinent
Govindasamy Kumaramanickavel
87. Type 2 Diabetes Mellitus in India
Radha Venkatesan, Kanthimathi Sekar and Viswanathan Mohan
88. Hereditary Spinocerebellar Ataxias in India
Mohammed Faruq, Uma Mittal, Achal K. Srivastava, and Mitali Mukerji
89. Malformation Syndromes in India
Shubha Phadke
90. Thalassemias and Abnormal Hemoglobins of the Indian Subcontinent
John Old
91. The Management of Inherited Blood Diseases in the Indian Subcontinent
Reena Das
92. Conventional and Molecular Cytogenetics in India
Prochi F. Madon
93. Genetic Studies of Parkinson's Disease in India
Jharna Ray
94. The Genetic Basis of Alcoholism in India
Meera Vasani
95. The Genetics of Autism in India
G.K. Chetan, K.R. Manjunatha, Sam Balu, H.N. Venkatesh, and S.C. Grimaji
96. The Genetics of Leprosy in India
Mariakuttikan Jayalakshmi, Narayanan Kalyanaraman, and Ramasamy Pitchappan
97. The Current Status of Medical Genetics in India
Neerja Gupta and Madhulika Kabra
98. The Indian Landscape of Human/Medical Genetics Research and Service
Swati Naik, Arvind Rup Singh, and Jai Rup Singh
Latin America and the Caribbean
99. Design and Implementation of a Platform for Genomic Medicine in Mexico
Gerardo Jimenez-Sanchez, Julio Frenk, and Guillermo Soberon
100. Anthropological and Medical Implications of Genetic Admixture in the Mexican Mestizo Population
Ricardo M. Cerda-Flores and Augusto Rojas-Martinez
101. Medical and Human Genetics in Ecuador
Cesar Paz-y-Mino
102. The Brazilian Ancestrome
Sergio D.J. Pena
103. The Practice of Medical Genetics in Brazil
Dafne Dain Gandelman Horovitz, Antonia Paula Marques-de-Faria, and Victor Evangelista de Faria Ferraz
104. Population Medical Genetics in Brazil
Lavinia Schuller-Faccini and Roberto Giugliani
105. Medical Genetic Services in Latin America: Focus in Argentina
Victor B. Penchaszadeh
106. Hereditary Ataxias in Cuba
Luis Velazquez-Perez, Jose Miguel Laffita-Mesa, and Roberto Rodriguez-Labrada
107. Latin American School of Human and Medical Genetics and Latin American Network of Human Genetics: promoting education, interaction and networking across Latin America
Roberto Giugliani, Guilherme Baldo, and Ursula Matte
Russia, Central Asia, and Europe
108. Genetic Legacy of Populations in Eurasia
I.A. Kutuev, B.B. Yunusbayev, and E.K. Khusnutdinova
109. MtDNA and Y-chromosomal Variation in Populations of Sakha (Yakutia)
Sardana A. Fedorova, Elza K. Khusnutdinova, and Richard Villems
110. Epidemiology of Hereditary Diseases in the European Sector of Russia
E.K. Ginter and R.A. Zinchenko
111. Hereditary Diseases among the Yakuts
Nadezda R. Maksimova and Anna N. Nogovitsina
112. Hereditary Diseases in Siberian Populations
Ludmila P. Nazarenko and V.P. Puzyrev
113. Hereditary Diseases in the Volga-Ural Region of Russia
Irina M. Khidiyatova, Irina R. Gilyazova, Vita L. Akhmetova and Elza K. Khusnutdinova
114. Inherited Neuropsychiatric Disorders in Russia
D. Gaysina, A. Zainullina, and E. Khusnutdinova
115. Genetic and Genomic Perspectives of Medical and Health Education in Hungary
Bela Melegh
116. Human and Medical Genetics in Hungary
Bela Melegh
117. The Genetics of Alcohol Dependence in Russia
A. Kazantseva, G. Faskhutdinova, and E. Khusnutdinova
118. Medical Genetics Teaching and Training in Russia
S.I. Kozlova and E.K. Ginter
119. Ethical and Legal Aspects of Medical Genetics in Russia
V.L. Izhevskaya and V.I. Ivanov
120. Bioethical Aspects of Genetics and Genomics in Yakut (Siberia)
S.K. Kononova, S.A. Fedorova, and E. Khusnutdinova
121. Inherited Metabolic Diseases among Migrant Ethnic Populations in the United Kingdom
Anupam Chakrapani and Maureen Cleary
122. Views of Inherited illness among British Pakistani Users of Genetic Services
Alison Shaw and Jane Hurst
123. Social, Cultural, and Religious Issues Related to Genetic Diseases among the Bangladeshis in the UK
Santi Rozario and Sophie Gilliat-Ray

About the author: 

Dhavendra Kumar, MD, FRCP, FACMG, is Professor, the University of Glamorgan, and Consultant in Clinical Genetics at the University Hospital of Wales, Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom.

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