Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease

ISBN : 9780190497996

Susan A. Masino
424 Pages
178 x 254 mm
Pub date
Oct 2016
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Ketogenic diets have been used to successfully treat epilepsy and stop seizures for nearly a century. When more traditional therapies, such as pharmacology, reach their limitations for treatment, the metabolic approach surpasses, targeting the overall physiology and homeostatic functions of the patient. Ketogenic Diet and Metabolic Therapies is the first comprehensive scientific resource on the ketogenic diet, covering the latest research including the biomedical mechanisms, established and emerging applications, metabolic alternatives, and implications for health and disease. Experts in clinical and basic research share their research into mechanisms spanning from ion channels to epigenetics, their insights based on decades of experience with the ketogenic diet in epilepsy, and their evidence for emerging applications ranging from autism to Alzheimer's disease to brain cancer. Research in metabolic therapies has spread into laboratories and clinics of every discipline, and is yielding to entirely new classes of drugs and treatment regimens. The book's editor, Susan A. Masino, brings her unique expertise in clinical and research neurology to the overall scope of this work. To further enhance the scope and quality of this one of a kind book, section editors Eric Kossoff, Jong Rho, Detlev Boison, and Dominic P. D'Agostino lend their oversight on their respective sections.


Contributors List
Section I Ketogenic Diet for Epilepsy in the Clinic
Eric Kossoff, MD, Section Editor
Chapter 1 Overview- Ketogenic Diets and Pediatric Epilepsy: An Update
Eric Kossoff, MD
Chapter 2 'Alternative' Ketogenic Diets
Elizabeth Neal, RD, MSc, PhD
Chapter 3 Dietary Therapy in Adults: History, Demand, and Results
Emily L. Johnson, MD and Mackenzie C. Cervenka, MD
Chapter 4 How Do You Implement the Diet?
Christina Bergqvist, MD
Chapter 5 Glut1 Deficiency and the KD
Joerg Klepper, MD, PhD
Chapter 6 Ketogenic Diet in Established Epilepsy Indications
Ann Bergin, MD, MB, ScM, MRCP
Chapter 7 Ketogenic Diet for Other Epilepsies
David T. Hsieh, MD and Elizabeth A. Thiele, MD, PhD
Chapter 8 The Ketogenic Diet and Related Therapies in Novel Situations: Idiopathic Generalized Epilepsy Syndromes
Sudha Kilaru Kessler MD, MSCE
Chapter 9 Ketogenic Diet in Status Epilepticus
Rima Nabbout, MD, PhD
Chapter 10 Preventing Side Effects and Diet Discontinuation
Cherie L. Herren, MD and Rana R. Said, MD
Section II Ketogenic Diet - Emerging Clinical Applications and Future Potential
Jong M. Rho, MD, Section Editor
Chapter 11 Overview: Expanded Uses of Ketogenic Therapies
Jong M. Rho, MD
Chapter 12 Metabolism-Based Treatments to Counter Cancer: Scientific Rationale
Thomas N. Seyfried, PhD and Laura Shelton, PhD
Chapter 13 Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer
Eric C. Woolf, PhD and Adrienne C. Scheck, PhD
Chapter 14 Metabolic Therapy for Autism Spectrum Disorder and Co-Morbidities
Ning Cheng, PhD, Susan A. Masino, PhD, and Jong M. Rho, MD
Chapter 15 Glucose and Ketone Metabolism in the Aging Brain: Implications for Therapeutic Strategies to Delay the Progression of Alzheimer's Disease
Stephen C. Cunnane, PhD, Alexandre Courchesne-Loyer, MSc, Valerie St-Pierre, BSc, Camille Vandenberghe, PhD, Etienne Croteau, PhD, and Christian-Alexandre Castellano, PhD
Chapter 16 Ketogenic Diet and Ketones for the Treatment of Traumatic Brain and Spinal Cord Injury
Femke Streijger, PhD, Ward T. Plunet, PhD, and Wolfram Tetzlaff, MD, Dr.Med, PhD
Chapter 17 Anti-Inflammatory Effects of a Ketogenic Diet: Implications for New Indications
Nina Dupuis, PhD and Stephane Auvin, MD, PhD
Chapter 18 Dietary Therapy for Neurological Disorders: Focus on Amyotrophic Lateral Sclerosis, Parkinson's Disease, Mood Disorders, and Migraine
Carl E. Stafstrom, MD, PhD
Section III Ketogenic Diet in the Laboratory
Detlev Boison, PhD Section Editor
Chapter 19 Overview of Ketogenic Diet in the Laboratory: Progress on Models and Mechanisms
Detlev Boison PhD
Chapter 20 Ketogenic Diet and PPARg
Timothy A. Simeone, PhD
Chapter 21 Ketogenic Diet in a Hippocampal Slice: Models and Mechanisms
Masahito Kawamura, Jr, PhD
Chapter 22 Metabolic Therapy and Pain
David N. Ruskin, PhD
Chapter 23 Ketogenic Diet, Adenosine, Epigenetics, and Antiepileptogenesis
Theresa A. Lusardi, PhD and Detlev Boison, PhD
Chapter 24 Ketogenic Diet, Aging, and Neurodegeneration
Kui Xu, MD, PhD, Joseph C. LaManna, PhD and Michelle A. Puchowicz, PhD
Chapter 25 Endocrine and Reproductive Effects of Ketogenic Diets
Jacob P. Harney, PhD, Kathryn Gudsnuk, MS, Ami Patel, MD Anantha R. Vellipuram, MD, Sathyajit Bandaru, MS and David Butler, MS
Chapter 26 Alzheimer's Disease: Causes and Treatment
Richard L. Veech, MD, PhD, DPhil and M. Todd King
Chapter 27 Mitigation of Damage from Reactive Oxygen Species and Ionizing Radiation by Ketone Body Esters
William Curtis, Martin Kemper, PhD, Alexandra Miller, PhD, Robert Pawlosky, PhD, M. Todd King, and Richard L. Veech, MD, PhD, DPhil
Chapter 28 Metabolic Seizure Resistance via BAD and KATP Channels
Juan Ramon Martinez-Francois, PhD, Nika Danial, PhD, and Gary Yellen, PhD
Chapter 29 Lactate Dehydrogenase: A Novel Metabolic Target
Nagisa Sada, PhD and Tsuyoshi Inoue, PhD
Chapter 30 Effects of the Ketogenic Diet on the Blood-Brain Barrier
Manoj Banjara, PhD and Damir Janigro, PhD
Section IV Ketone-Based Metabolism: General Health and Metabolic Alternatives
Dominic P. D'Agostino, PhD Section Editor
Chapter 31 Overview of Ketone-Based Metabolism: General Health and Metabolic Alternatives
Dominic P. D'Agostino, PhD
Chapter 32 Ketone Supplementation for Health and Disease
Angela M. Poff, PhD, Shannon L. Kesl, PhD, and Dominic P. D'Agostino, PhD
Chapter 33 Identifying the Molecular Mechanism of the MCT (Ketogenic) Diet
Matthew C. Walker, PhD and Robin S.B. Williams, PhD
Chapter 34 Triheptanoin in Epilepsy and Beyond
Karin Borges, PhD
Chapter 35 Amino Acids in the Treatment of Neurological Disorders
Adam L. Hartman, MD
Chapter 36 2-Deoxyglucose: Metabolic Control of Seizures through Inhibition of Glycolysis
Carl E. Stafstrom, MD, PhD and Thomas P. Sutula, MD, PhD
Chapter 37 Ketogenic Diets as Highly Effective Treatments for Diabetes Mellitus and Obesity
Eric C. Westman, MD, MHS, Emily Maguire, MSc, and William S. Yancy Jr., MD, MHS
Chapter 38 Keto-Adaptation in Health and Fitness
Parker Hyde, CSCS, CISSN, Vincent J. Miller, PhD, and Jeff S. Volek, PhD, RD
Chapter 39 Advancing the Awareness and Application of Ketogenic Therapies Globally: The Charlie Foundation and Matthew's Friends
Beth Zupec-Kania, RD, CD, Jim Abrahams, Emma Williams, MBE, Susan A. Masino, PhD

About the author: 

Susan A. Masino is the Vernon Roosa Professor of Applied Science at Trinity College. Her research is focused on adenosine, an endogenous molecule that promotes homeostasis and links between metabolism and brain activity. In 2008 she proposed that adenosine is a key mechanism underlying ketogenic diet therapy; based on this, her research spans multiple conditions. Dr. Masino is also dedicated to educational, environmental and public policy issues affecting brain health.

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