ISBN : 9780198714682
Viruses are some of the simplest infectious agents on the planet, yet can cause severe and even life-threatening diseases in all forms of life - including humans. Despite relying on host cells in order to replicate, viruses can be capable of extremely rapid reproduction and very effective transmission from one person to another. Because of this, they have historically represented a significant proportion of the disease burden affecting humans, in addition to a number of new high profile diseases which have emerged in the last century. However, on a more positive note, the only two diseases to have ever been eradicated by mankind were both viruses, giving hope that in the future more viruses can be eliminated. Human Virology provides a vivid introduction to this fascinating field, by incorporating both the molecular and clinical aspects of the subject. The general principles and properties of viruses are covered in the first part of the text, while part two provides a survey of the different virus families and the human diseases they cause. Finally, the book concludes with some of the more practical aspects of the subject, such as immunization, antiviral chemotherapy and laboratory techniques. Throughout the text, case studies bring the subject to life by providing a unique perspective from real practicing doctors. In addition new 'hot topic' boxes have been incorporated into this edition, featuring current important areas of research. Little prior knowledge is assumed, making Human Virology the perfect text for those students new to the subject. The Online Resource Centre to accompany Human Virology features: For students: *multiple-choice questions for self-directed learning *Web links to online animations and videos For lecturers: *Figures from the book in electronic format, ready to download
Part 1: General principles
1 Virology: how it all began and where it will go
2 General properties of viruses
3 Viral replication and genetics
4 How viruses cause disease
5 Resistance of the human body to virus infections
6 Viruses and the community: the science and practice of epidemiology
Part 2: Specific viruses
Group 1 - Positive sense single stranded RNA viruses
7 Picornaviruses: polio, hepatitis A, and common cold
8 Astroviruses: gastroenteritis agents
9 Calciviruses: norovirus and gastroenteritis
10 Hepeviruses: hepatitis E
11 Togaviruses: mosquito borne, Chikungunya, Rubella, and a teratogen
12 Flaviviruses: mosquito borne, yellow fever, dengue, blood borne Hepatitis C
13 Coronaviruses: respiratory MERS, SARS
Group 2 - Negative sense single stranded RNA viruses
14 Myxoviruses: influenza A, B, C
15 Arenaviruses: Lassa and haemorrhagic fevers
16 Bunyaviruses: hanta, phlebo, and nairo viruses
17 Paramyxoviruses: respiratory syncytial virus, meta pneumo virus and emerging Hendra and Nipah
18 Filoviruses: zoonotic, Marburg, and Ebola
19 Rabies: zoonotic rabies
Group 3 - Double stranded RNA viruses
20 Reoviruses: rota and diarrhoea viruses
Group 4 - Double stranded DNA viruses
21 Polyomaviruses
22 Papillomaviruses: warts and cervical carcinoma
23 Herpes viruses: herpetic lesions, cancer, and encephalitis
24 Smallpox: human disease eradicated but zoonotic infections common
25 Adenovirus: respiratory, eye, and gastroenteritis viruses
Group 5 - Single stranded DNA viruses
26 Parvovirus: childhood rash, aplastic crisis, foetal infection
Group 6 - Single stranded positive sense RNA with an RT
27 Retroviruses: HIV 1 and 2 and HTLV
Group 7 - Circular double stranded DNA viruses with an RT
28 Hepadnaviruses: hepatitis B and D
Part 3: Practical aspects
29 The clinical virology laboratory: molecular techniques
30 Control of viral disease by immunisation
31 Antiviral chemotherapy
