Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton (2nd edition)

ISBN : 9780199607990

Roger Smith; Paul Wordsworth
448 Pages
219 x 276 mm
Pub date
Mar 2016
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Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton 2 is a definitive reference providing comprehensive coverage of common polygenic and rare monogenic disorders, emphasizing new advances in bone cell biology and human skeletal disease. With an up-to-date account of common and rare metabolic disorders of the skeleton, including their causes, clinical aspects, and treatment, this book offers the reader clarity in the complex field of the molecular biology of the skeleton. Topics covered include bone biology and investigation, osteoporosis, osteomalacia and rickets, parathyroid bone disease, Paget disease, and the effects of malignancy on the skeleton. Newer metabolic bone disorders are also included, along with chapters on osteogenesis imperfecta, skeletal dysplasias, osteopetrosis and osteosclerosis, Marfan syndrome, Ehlers-Danlos syndrome, fibrous dysplasia, and ectopic mineralisation. Essential for postgraduates and clinicians, this accessible and highly illustrated book provides a clear authoritative account of metabolic bone diseases in their widest sense. Bringing together considerable advances in the field, it discusses molecular causes and personal experiences of all disorders, ensuring a comprehensive and didactic reference. Enriched with over 100 new illustrations and revised chapters to reflect a rapidly developing field, this second edition will be indispensable for those who look after patients with metabolic bone disease, including general physicians, rheumatologists, endocrinologists, and orthopaedic surgeons, along with paediatricians and geneticists. This print edition of The Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.


1 Introduction to clinical and biochemical disorders of the skeleton
2 The physiology and pathology of bone
3 Diagnosis and investigation
4 Osteoporosis
5 Osteomalacia and rickets
6 Parathyroids and the skeleton
7 Paget disease
8 Neoplastic disease and other non-parathyroid causes of hypercalcaemia
9 Osteogenesis imperfecta and other disorders of low bone density
10 Skeletal dysplasias and related conditions
11 Osteopetrosis and osteosclerosis
12 Marfan syndrome and related disorders
13 Ehlers-Danlos syndrome and related disorders
14 Enzyme defects and the skeleton
15 Fibrous dysplasia
16 Fibrogenesis imperfecta ossium and other disorders of mineralization
17 Ectopic mineralization
18 Recent advances

About the author: 

Roger Smith is an Honorary Consultant Physician at the Nuffield Orthopaedic Centre, Oxford.; Paul Wordsworth is a Professor of Rheumatology at the University of Oxford and an Honorary Consultant Rheumatologist at Nuffield Orthopaedic Centre, Oxford. Professor Wordsworth qualified in medicine from Westminster Hospital, University of London in 1975 and has worked in Oxford since 1980, initially as Senior Registrar in Rheumatology and Rehabilitation and subsequently as a Research Fellow in the Nuffield Departments of Pathology and Medicine. He was appointed Clinical Reader in Rheumatology in 1992 and was awarded a personal chair in 1998. He won the Michael Mason prize from the British Society of Rheumatology.

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