OXFORD UNIVERSITY PRESS

Crucible of Science: The Story of the Cori Laboratory

ISBN : 9780199861071

Price(incl.tax): 
¥8,624
Author: 
John H. Exton
Pages
254 Pages
Format
Hardcover
Size
166 x 241 mm
Pub date
May 2013
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"Crucible of Science" is the story of a unique laboratory at Washington University in St. Louis, and of Carl and Gerty Cori, the biochemists who established it. Carl and Gerty met and married at medical school in Prague in the 1920s. After graduation, they immigrated to the U.S. to escape deteriorating conditions in Europe. Carl soon received an offer from Washington University to become Pharmacology Chair, and the couple settled in St. Louis. Not only did both Coris go on to win the Nobel Prize, the laboratory they established at the University has since produced some of the most outstanding scientists the U.S. has ever seen. Six laboratory scientists also won Nobel Prizes; few, if any, laboratories can claim such an impressive record. The Coris themselves were instrumental in establishing the then new science of Biochemistry in the U.S. They applied chemical approaches to elucidating the transformations of compounds such as glucose in animal tissues and defined the enzyme BIOL15GENRthat carried out those transformations. Both scientists were extremely rigorous in designing their experiments and interpreting the results, a habit that ensured their findings were above question. This book examines the careers of both Coris and the other eminent scientists who trained in their laboratory. It notes the Coris' acceptance of women, Jews, and scientists from all over the world, unique during this time period. It analyzes those reasons why the laboratory was so successful in attracting the best trainees and producing premier scientists. Intended for scientists, science historians, and anyone interested in the history of science, "Crucible of Science" is a unique presentation of remarkable careers and personalities, examined within the context of the Coris' laboratory.

Index: 

INTRODUCTION
CHAPTER 1 - CARL AND GERTY CORI
CHAPTER 2 - SIDNEY COLOWICK - THEIR FIRST GRADUATE STUDENT
CHAPTER 3 - HERMAN KALCKAR - THE GREAT DANE
CHAPTER 4 - SEVERO OCHOA - SPANISH GENIUS
CHAPTER 5 - MOVE TO ENZYMOLOGY AND WORK OF ARDA GREEN
CHAPTER 6 - LUIS LELOIR - ONE OF ARGENTINA'S GREATEST SCIENTISTS
CHAPTER 7 - EARL SUTHERLAND - MASTER OF INTUITION
CHAPTER 8 - CORI'S MOVE TO THE DEPARTMENT OF BIOLOGICAL CHEMISTRY - AWARD OF NOBEL PRIZES AND CAREER OF TOM CORI
CHAPTER 9 - SIDNEY VELICK - MODEST ENZYMOLOGIST
CHAPTER 10 - VICTOR NAJJAR - PEDIATRICIAN AND IMMUNOCHEMIST
CHAPTER 11 - EDWIN KREBS - ACCIDENTAL BIOCHEMIST
CHAPTER 12 - MILDRED COHN - AGAINST ALL ODDS
CHAPTER 13 - CHRISTIAN de DUVE - BELGIAN WITH SAVOIR FAIRE
CHAPTER 14 - ARTHUR KORNBERG - A GIANT OF BIOCHEMISTRY
CHAPTER 15 - HORMONE EFFECTS ON MUSCLE CARBOHYDRATE METABOLISM
CHAPTER 16 - CHARLES PARK - ARISTOCRATIC PHYSIOLOGIST
CHAPTER 17 - JANE HARTING PARK - ENTHUSIAST FOR SCIENCE
CHAPTER 18 - GERTY CORI'S WORK ON GLYCOGEN STRUCTURE AND GLYCOGEN STORAGE DISEASES
CHAPTER 19 - JOSEPH LARNER - FOCUS ON GLYCOGEN SYNTHASE
CHAPTER 20 - CONTRIBUTIONS OF BARBARA AND DAVID BROWN
CHAPTER 21 - WILLIAM DAUGHADAY - ALL ABOUT GROWTH
CHAPTER 22 - ROBERT CRANE - A DECADE WITH CARL CORI
CHAPTER 23 - ALBERTO SOLS - SPANISH ENZYMOLOGIST
CHAPTER 24 - LUIS GLASER - THE COMPLEXITY OF CARBOHYDRATES
CHAPTER 25 - ERNST HELMREICH - JOVIAL BAVARIAN
CHAPTER 26 - CARL FRIEDEN - ENZYME KINETICIST
CHAPTER 27 - DAVID KIPNIS - DIABETOLOGIST
CHAPTER 28 - WILLIAM DANFORTH - ACADEMIC LEADER
CHAPTER 29 - THE INFLUENCE OF THE CORIS ON WASHINGTON UNIVERSITY AND CARL CORI'S RESEARCH AT BOSTON
CHAPTER 30 - THE HERITAGE OF THE CORIS

About the author: 

John H. Exton is Professor of Molecular Physiology and Biophysics at the Vanderbilt University School of Medicine, and Investigator at Howard Hughes Medical Institute.

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