The OMICs: Applications in Neuroscience

ISBN : 9780199855452

Giovanni Coppola
384 Pages
181 x 254 mm
Pub date
Jan 2014
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The OMICs:Applications in Neuroscience summarizes the state of the art in OMICs applications in neurology and neuroscience, attracting neurologists who are interested in the progress of this field towards clinical applications, and neuroscientists who may be not familiar with the most recent advances in this ever-changing field. The book will include an overview of most relevant high-throughput approaches (collectively known as 'OMICs') and how they relate to neurology and neuroscience. The explosion of high-throughput assays has introduced large datasets, computational servers, and bioinformatics approaches to neuroscience and medicine in general. The reader will be provided with an overview of the application or method, a perspective on the current and future applications in neurology and neuroscience, and a few published examples illustrating possible practical use. Emerging topics such as ethical issues related to personal genome sequencing, epigenetics, network analysis, and role of peripheral biomarkers in disease diagnosis and follow-up will be covered as well.


Section 1. DNA
Chapter 1: Medical DNA Sequencing in Neuroscience
Chapter 2: Epigenomics: an Overview
Chapter 3: The Role Of Epigenomics In Genetically Identical Individuals
Section 2. RNA
Chapter 5: Decoding alternative mRNAs in the OMIC-age
Chapter 6: Transcriptomics: from Differential Expression to Coexpression
Chapter 7: High-Throughput-RNA Interference As A Tool For Discovery in Neuroscience
Chapter 8: The Genetics Of Gene Expression: Multiple Layers and Multiple Players
Section 3. PROTEIN
Chapter 9: Proteomics
Chapter 10: Focused plasma proteomics for the study of brain aging and neurodegeneration
Chapter 11: Cellomics: Characterization of Neuronal Subtypes by High-Throughput Transgenic Mouse Models
Chapter 12: Neuroscience and Metabolomics
Chapter 13: Brain Connectomics in Man and Mouse
Chapter 14: Optogenetics
Chapter 15: Characterising the Gut Microbiome: Role in Brain-Gut Function
Chapter 16: OMICS in Drug Discovery: From Small Molecule Leads to Clinical Candidates
Chapter 17: Pharmacogenomics
Section 6. OMICsOME: integration of OMICs data
Chapter 18: Multidimensional Databases Of Animal Models
Chapter 19: Network Biology and Molecular Medicine in the Post Genomic Era: The Systems Pathobiology of Network Medicine

About the author: 

Giovanni Coppola, MD Assistant Professor Laboratory of Neurogenetics Department of Neurology, David Geffen School of Medicine

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